WordNet

(pathology) a small abnormal patch on or inside the body
loss of the myelin covering of some nerve fibers resulting in their impaired function

PrepTutorEJDIC

(金属・陶器などの)飾り額,飾り板

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1. 成人の多発性硬化症の評価と診断evaluation and diagnosis of multiple sclerosis in adults [show details]
… MRI sequences . It is difficult to distinguish the edema of an acute plaque from the gliosis and demyelination of a chronic plaque with conventional MRI technology. In addition, conventional MRI techniques …
2. 成人に現れる多発性硬化症の症状と徴候manifestations of multiple sclerosis in adults [show details]
… due to an upper motor neuron lesion caused by demyelination of the corticospinal system,… vertigo is often directly related to the development of demyelinating plaques in the vestibular pathways such as the medullary…
3. 多発性硬化症の病態および疫学pathogenesis and epidemiology of multiple sclerosis [show details]
…clinical and pathologic features reflecting different pathways to tissue injury . Inflammation, demyelination, and axonal degeneration are the major pathologic mechanisms that cause the clinical manifestations … Myelin reactive T cells are found in MS plaques and in the CSF and the peripheral circulation of patients with MS .…
4. 成人の多発性硬化症の臨床症状、経過、予後clinical presentation course and prognosis of multiple sclerosis in adults [show details]
… CIS there is no evidence of previous episodes of demyelination from the patient history.… and brainstem; and large plaques detected by MRI may not have functional correlates but…
5. 三叉神経痛trigeminal neuralgia [show details]
… facial pain . Demyelination of one or more of the trigeminal nerve nuclei may also be caused by multiple sclerosis or other structural lesions of the brainstem. In multiple sclerosis, a plaque of demyelination …

English Journal

Multiple Sclerosis CD49dCD154 As Myelin-Specific Lymphocytes Induced During Remyelination.

Piatek P, Namiecinska M, Domowicz M, Wieczorek M, Michlewska S, Matysiak M, Lewkowicz N, Tarkowski M, Lewkowicz P.
Cells. 2019 Dec;9(1).
Multiple sclerosis (MS) is a demyelinating autoimmune disease of the central nervous system (CNS) mediated by autoreactive lymphocytes. The role of autoreactive lymphocytes in the CNS demyelination is well described, whereas very little is known about their role in remyelination during MS remission.
PMID 31861635

Sphingosine Kinase 2 Potentiates Amyloid Deposition but Protects against Hippocampal Volume Loss and Demyelination in a Mouse Model of Alzheimer's Disease.

Lei M, Teo JD, Song H, McEwen HP, Yup Lee J, Couttas TA, Duncan T, Chesworth R, Bertz J, Przybyla M, Van Eersel J, Heng B, Guillemin GJ, Ittner LM, Fath T, Garner B, Ittner A, Karl T, Don AS.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 2019 Nov;39(48)9645-9659.
Sphingosine 1-phosphate (S1P) is a potent vasculoprotective and neuroprotective signaling lipid, synthesized primarily by sphingosine kinase 2 (SK2) in the brain. We have reported pronounced loss of S1P and SK2 activity early in Alzheimer's disease (AD) pathogenesis, and an inverse correlation betwe
PMID 31641049

TGFB1-Mediated Gliosis in Multiple Sclerosis Spinal Cords Is Favored by the Regionalized Expression of HOXA5 and the Age-Dependent Decline in Androgen Receptor Ligands.

Nataf S, Guillen M, Pays L.
International journal of molecular sciences. 2019 Nov;20(23).
In multiple sclerosis (MS) patients with a progressive form of the disease, spinal cord (SC) functions slowly deteriorate beyond age 40. We previously showed that in the SC of these patients, large areas of incomplete demyelination extend distance away from plaque borders and are characterized by a
PMID 31779094

Japanese Journal

多発性硬化症病変分子のネットワーク解析

佐藤準一
日本臨床免疫学会会誌 = Japanese journal of clinical immunology 33(4), 182-188, 2010-08-31
… 451 : 1076-1081, 2008）．Hanらはステージを確認した病巣からlaser microdissectionで分離したサンプルを質量分析で解析して，4324種類のタンパク質を同定した．彼らは慢性活動性脱髄巣（chronic active plaque ; …
NAID 10027753629

Ｅｄｕｃａｔｉｏｎ　Ｐｒｏｇｒａｍ　３　多発性硬化症の臨床研究の最近の進歩：アストロサイトパチーからみた脱髄

吉良潤一
臨床神経学 50(11), 788-793, 2010
視神経脊髄炎（neuromyelitis optica，NMO）は，NMO-IgGの発見により多発性硬化症（multiple sclerosis，MS）とは病態機序が異なる独立した疾患とする説が有力となっている．NMO-IgGが認識するaquaporin-4（AQP4）がアストロサイトの足突起に存在する水チャネル分子であることから，NMO-IgG（抗AQP4抗体）が，アストロサイトの足突起上のAQ …
NAID 130004504627

Proton Magnetic Resonance Spectroscopy and Diffusion-Weighted Imaging of Tumefactive Demyelinating Plaque : Case Report

MASU Kazuki,BEPPU Takaaki,FUJIWARA Shunrou,KIZAWA Hideki,KASHIMURA Hiroshi,KUROSE Akira,OGASAWARA Kuniaki,SASAKI Makoto
Neurologia medico-chirurgica = 神経外科 49(9), 430-433, 2009-09-15
… Proton magnetic resonance spectroscopy, diffusion-weighted axonography, and diffusion tensor tractography in a patient with tumefactive demyelination plaque (TDP) were evaluated for differential diagnosis from glioblastoma. …
NAID 10025948718