WordNet

(biochemistry) a class of hemoprotein whose principal biological function is electron transfer (especially in cellular respiration)

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1. 成人腎移植レシピエントの診療の概要 overview of care of the adult kidney transplant recipient
2. 小児または思春期のアスリートにおける頸部の筋骨格損傷の概要 overview of musculoskeletal neck injuries in the child or adolescent athlete
3. 頚椎性頭痛 cervicogenic headache
4. 補体系の遺伝性疾患 inherited disorders of the complement system
5. 肺移植後の免疫抑制の維持 maintenance immunosuppression following lung transplantation

English Journal

Nonredundant Roles for Cytochrome c2 and Two High-Potential Iron-Sulfur Proteins in the Photoferrotroph Rhodopseudomonas palustris TIE-1.

Bird LJ, Saraiva IH, Park S, Calçada EO, Salgueiro CA, Nitschke W, Louro RO, Newman DK.Author information Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.AbstractThe purple bacterium Rhodopseudomonas palustris TIE-1 expresses multiple small high-potential redox proteins during photoautotrophic growth, including two high-potential iron-sulfur proteins (HiPIPs) (PioC and Rpal_4085) and a cytochrome c2. We evaluated the role of these proteins in TIE-1 through genetic, physiological, and biochemical analyses. Deleting the gene encoding cytochrome c2 resulted in a loss of photosynthetic ability by TIE-1, indicating that this protein cannot be replaced by either HiPIP in cyclic electron flow. PioC was previously implicated in photoferrotrophy, an unusual form of photosynthesis in which reducing power is provided through ferrous iron oxidation. Using cyclic voltammetry (CV), electron paramagnetic resonance (EPR) spectroscopy, and flash-induced spectrometry, we show that PioC has a midpoint potential of 450 mV, contains all the typical features of a HiPIP, and can reduce the reaction centers of membrane suspensions in a light-dependent manner at a much lower rate than cytochrome c2. These data support the hypothesis that PioC linearly transfers electrons from iron, while cytochrome c2 is required for cyclic electron flow. Rpal_4085, despite having spectroscopic characteristics and a reduction potential similar to those of PioC, is unable to reduce the reaction center. Rpal_4085 is upregulated by the divalent metals Fe(II), Ni(II), and Co(II), suggesting that it might play a role in sensing or oxidizing metals in the periplasm. Taken together, our results suggest that these three small electron transfer proteins perform different functions in the cell.
Journal of bacteriology.J Bacteriol.2014 Feb;196(4):850-8. doi: 10.1128/JB.00843-13. Epub 2013 Dec 6.
The purple bacterium Rhodopseudomonas palustris TIE-1 expresses multiple small high-potential redox proteins during photoautotrophic growth, including two high-potential iron-sulfur proteins (HiPIPs) (PioC and Rpal_4085) and a cytochrome c2. We evaluated the role of these proteins in TIE-1 through g
PMID 24317397

N-acetyltransferase 2, cytochrome P4502E1 and glutathione S-transferase genotypes in antitubercular treatment-induced hepatotoxicity in North Indians.

Rana SV, Sharma SK, Ola RP, Kamboj JK, Malik A, Morya RK, Sinha SK.Author information Department of Super Specialty Gastroenterology, Post Graduate Institute of Medical Education & Research, Chandigarh, India.AbstractWHAT IS KNOWN AND OBJECTIVE: Tuberculosis (TB) is a major cause of illness and death in developing countries. Hepatotoxicity is a serious side effect of antituberculosis treatment (ATT). NAT2, CYP2E1 and glutathione S-transferase (GST) gene polymorphisms may play an important role in ATT-induced hepatotoxicity. So, elucidating the genetics involved in anti-TB drug-induced hepatotoxicity in patients would be of utmost clinical significance. Therefore, the objective of the study was to elucidate the role of NAT2, CYP2E1 and GST gene polymorphisms in ATT-induced hepatotoxicity in North Indian patients.
Journal of clinical pharmacy and therapeutics.J Clin Pharm Ther.2014 Feb;39(1):91-6. doi: 10.1111/jcpt.12105. Epub 2013 Nov 5.
WHAT IS KNOWN AND OBJECTIVE: Tuberculosis (TB) is a major cause of illness and death in developing countries. Hepatotoxicity is a serious side effect of antituberculosis treatment (ATT). NAT2, CYP2E1 and glutathione S-transferase (GST) gene polymorphisms may play an important role in ATT-induced hep
PMID 24188272

Critical appraisal of 13 C breath tests for microsomal liver function: aminopyrine revisited.

Pijls KE, de Vries H, Nikkessen S, Bast A, Wodzig WK, Koek GH.Author information Division of Gastroenterology and Hepatology, Department of Internal Medicine, Maastricht University Medical Center, Maastricht, the Netherlands.AbstractAs liver diseases are a major health problem and especially the incidence of metabolic liver diseases like non-alcoholic fatty liver disease (NAFLD) is rising, the demand for non-invasive tests is growing to replace liver biopsy. Non-invasive tests such as carbon-labelled breath tests can provide a valuable contribution to the evaluation of metabolic liver function. This review aims to critically appraise the value of the 13 C-labelled microsomal breath tests for the evaluation of metabolic liver function, and to discuss the role of cytochrome P450 enzymes in the metabolism of the different probe drugs, especially of aminopyrine. Although a number of different probe drugs have been used in breath tests, the perfect drug to assess the functional metabolic capacity of the liver has not been found. Data suggest that both the 13 C2 -aminopyrine and the 13 C-methacetin breath test can play a role in assessing the capacity of the microsomal liver function and may be useful in the follow-up of patients with chronic liver diseases. Furthermore, CYP2C19 seems to be an important enzyme in the N-demethylation of aminopyrine, and polymorphisms in this gene may influence breath test values, which should be kept in mind when performing the 13 C2 -aminopyrine breath test in clinical practice.
Liver international : official journal of the International Association for the Study of the Liver.Liver Int.2013 Dec 24. doi: 10.1111/liv.12451. [Epub ahead of print]
As liver diseases are a major health problem and especially the incidence of metabolic liver diseases like non-alcoholic fatty liver disease (NAFLD) is rising, the demand for non-invasive tests is growing to replace liver biopsy. Non-invasive tests such as carbon-labelled breath tests can provide a
PMID 24428683

Japanese Journal

80. イネのジテルペン型ファイトアレキシン生合成酵素遺伝子クラスターに存在するP450遺伝子の機能解析(口頭発表,植物化学調節学会第46回大会)

山崎浩平,蓑田裕美,岡田敦,岡田憲典,宮崎翔,川出洋,古賀仁一郎,矢島新,薮田五郎,豊増知伸,野尻秀昭,山根久和
植物化学調節学会研究発表記録集 (46), 96, 2011-10-03
… Previously, we reported that a novel gene cluster for phytocassane biosynthesis is organized in rice chromosome 2, which consists of two diterpene cyclase genes for phytocassanes (OsCPS2 and OsKSL7) and six cytochrome P450 monooxygenase (P450) genes (CYP71Z6, CYP71Z7, CYP76M5, CYP76M6, CYP76M7 and CYP76M8). …
NAID 110008902489

59.イネのファイトカサン生合成酵素遺伝子クラスターに存在するP450遺伝子の機能解析(口頭発表)

山崎浩平,蓑田裕美,岡田敦,岡田憲典,渋谷直人,古賀仁一郎,矢島新,薮田五郎,豊増知伸,野尻秀昭,山根久和
植物化学調節学会研究発表記録集 (45), 76, 2010-10-01
… Moreover, we showed that a novel gene cluster for phytocassane biosynthesis is organized in rice chromosome 2, which consists of two diterpene cyclase genes for phytocassanes (OsCPS2 and OsKSL7) and six cytochrome P450 monooxygenase (P450) genes (CYP71Z6, CYP71Z7, CYP76M5, CYP76M6, CYP76M7 and CYP76M8). …
NAID 110007767159