WordNet

viral disease in solanaceous plants (tomatoes, potatoes, tobacco) resulting in mottling and often shriveling of the leaves
arrangement of aerial photographs forming a composite picture (同)arial mosaic, photomosaic
art consisting of a design made of small pieces of colored stone or glass
transducer formed by the light-sensitive surface on a television camera tube
a pattern resembling a mosaic
a harmful or corrupting agency; "bigotry is a virus that must not be allowed to spread"; "the virus of jealousy is latent in everyone"
(virology) ultramicroscopic infectious agent that replicates itself only within cells of living hosts; many are pathogenic; a piece of nucleic acid (DNA or RNA) wrapped in a thin coat of protein
a software program capable of reproducing itself and usually capable of causing great harm to files or other programs on the same computer; "a true virus cannot spread to another computer without human assistance" (同)computer virus
fruit or seed of the cowpea plant (同)black-eyed_pea
sprawling Old World annual cultivated especially in southern United States for food and forage and green manure (同)cowpea plant, black-eyed_pea, Vigna unguiculata, Vigna sinensis
of or relating to Moses or the laws and writings attributed to him; "Mosaic Law"
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〈U〉モザイク(ガラス・木材・石などを組み合わせて図案化したもの) / 〈C〉《単数形で》モザイク画;モザイク模様
ビールス,ろ過性病原体
モーセ(Moses)の

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/11/23 19:58:10」(JST)

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Structure of the Cowpea Mosaic Virus based on PDB 2BFU

Cowpea mosaic virus (CPMV) is a plant virus of the comovirus group. Infection of a susceptible cowpea leaf results in high virus yields (1-2 g/kg). Its Genome consists of 2 molecules of positive-sense RNA (RNA-1 and RNA-2) which are separately encapsidated. Both RNA1 and RNA2 have a VPg (virus genome-linked protein) at the 5'end, and polyadenylation at the 3' end. Genomic RNA1 and RNA2 are expressed by a polyprotein processing strategy. RNA1 encodes helicase, VPg, protease and RdRp. RNA2 encodes movement protein and coat protein. The virus particles are 28 nm in diameter and contain 60 copies each of a Large (L) and Small (S) coat protein. The structure is well characterised to atomic resolution, and the viral particles are thermostable.

CPMV displays a number of features that can be exploited for nanoscale biomaterial fabrication. Its genetic, biological and physical properties are well characterised, and it can be isolated readily from plants. There are many stable mutants already prepared that allow specific modification of the capsid surface. It is possible to attach a number of different chemicals to the virus surface^[1]^[2] and to construct multilayer arrays of such nanoparticles on solid surfaces. This gives the natural or genetically engineered nanoparticles a range of properties which could be useful in nanotechnological applications such as biosensors, catalysis and nanoelectronic devices.

One example use of CPMV particles is to amplify signals in microarray based sensors. In this application, the virus particles separate the fluorescent dyes used for signaling in order to prevent the formation of non-fluorescent dimers that act as quenchers.^[3] Another example is the use of CPMV as a nanoscale breadboard for molecular electronics.^[4]

References[edit]

^ Q. Wang, T. Lin, L. Tang, J.E. Johnson, and M.G. Finn.Angew. Chem. Int. Ed.,41(3),459 (2002)
^ Q. Wang, T.R. Chan, R. Hilgraf, V.V. Fokin, K.B. Sharpless, and M.G. Finn. J. Am. Chem. Soc.,125,3192 (2003).
^ Fluorescent signal amplification of carbocyanine dyes using engineered viral nanoparticles. Carissa M. Soto, Amy Szuchmacher Blum, Nikolai Lebedev, Gary J. Vora, Carolyn E. Meador, Angela P. Won, Anju Chatterji, John E. Johnson, and Banahalli R. Ratna, Journal of the American Chemical Society, 128, 5184 (2006).
^ An Engineered Virus as a Scaffold for Three-Dimensional Self-Assembly on the Nanoscale. Amy Szuchmacher Blum, Carissa M. Soto, Charmaine D. Wilson, Tina L. Brower, Steven K. Pollack, Terence L. Schull, Anju Chatterji, Tianwei Lin, John E. Johnson, Christian Amsinck, Paul Franzon, Ranganathan Shashidhar and Banahalli Ratna, Small, 7, 702 (2005).

External links[edit]

Separation and recovery of intact gold-virus complex by agarose electrophoresis and electroelution: Application to the purification of cowpea mosaic virus and colloidal gold complex
ICTVdB - The Universal Virus Database: Cowpea mosaic virus
Family Groups - The Baltimore Method
ICTV Virus Taxonomy 2009 [1]
UniProt Taxonomy

This plant virus article is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

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1. 水痘帯状疱疹ウイルス感染の予防：帯状疱疹 prevention of varicella zoster virus infection herpes zoster
2. 肺の高分解能CT high resolution computed tomography of the lungs
3. 骨パジェット病の臨床症状および診断 clinical manifestations and diagnosis of paget disease of bone
4. ステージII大腸癌切除後患者に対する補助化学療法 adjuvant chemotherapy for resected stage ii colon cancer
5. 成人における細気管支炎 bronchiolitis in adults

English Journal

Molecular targeted viral nanoparticles as tools for imaging cancer.

Cho CF, Shukla S, Simpson EJ, Steinmetz NF, Luyt LG, Lewis JD.SourceTranslational Prostate Cancer Research Group, University of Alberta, Edmonton, AB, Canada.
Methods in molecular biology (Clifton, N.J.).Methods Mol Biol.2014;1108:211-30. doi: 10.1007/978-1-62703-751-8_16.
Viral nanoparticles (VNPs) are a novel class of bionanomaterials that harness the natural biocompatibility of viruses for the development of therapeutics, vaccines, and imaging tools. The plant virus, cowpea mosaic virus (CPMV), has been successfully engineered to create novel cancer-targeted imagin
PMID 24243252

Genetic engineering and characterization of cowpea mosaic virus empty virus-like particles.

Sainsbury F, Saxena P, Aljabali AA, Saunders K, Evans DJ, Lomonossoff GP.SourceAustralian Institute for Bioengineering and Nanotechnology, University of Queensland, St-Lucia, QLD, Australia.
Methods in molecular biology (Clifton, N.J.).Methods Mol Biol.2014;1108:139-53. doi: 10.1007/978-1-62703-751-8_11.
The development of methods for the production of empty Cowpea mosaic virus (CPMV) virus-like particles (VLPs) that are devoid of RNA, eVLPs, has renewed promise in CPMV capsid technologies. The recombinant nature of CPMV eVLP production means that the extent and variety of genetic modifications that
PMID 24243247

Polyelectrolyte-modified cowpea mosaic virus for the synthesis of gold nanoparticles.

Aljabali AA, Evans DJ.SourceDepartment of Chemistry, University of Hull, Hull, UK.
Methods in molecular biology (Clifton, N.J.).Methods Mol Biol.2014;1108:97-103. doi: 10.1007/978-1-62703-751-8_7.
Polyelectrolyte surface-modified cowpea mosaic virus (CPMV) can be used for the templated synthesis of narrowly dispersed gold nanoparticles. Cationic polyelectrolyte, poly(allylamine) hydrochloride, is electrostatically bound to the external surface of the virus capsid. The polyelectrolyte-coated C
PMID 24243243

Japanese Journal

(6) キュウリモザイクウイルスダイズ系統のササゲ接種葉でのえそ斑誘導因子の同定(北海道部会講演要旨, 平成16年度地域部会講演要旨)

山本大輔,洪鎮成,花田薫,増田税
日本植物病理學會報 71(1), 82, 2005-02-25
NAID 110002769486

(373)植物ウイルスの干渉効果の機構に関する研究(VII)ササゲにおけるCMVサブグループI,II間の競合とRNA依存RNA合成酵素遺伝子mRNAの蓄積(平成15年度日本植物病理学会大会講演要旨)

竹下稔,重宗尚文,桑田茂,古屋成人,高浪洋一
日本植物病理學會報 69(3), 333, 2003-08-25
NAID 110002767357

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リンク元	「CPMV」「ササゲモザイクウイルス」
関連記事	「mosaic」「virus」

「CPMV」

Cowpea mosaic virus (CPMV)
Virus classification
Group:	IV: (+)sense RNA Viruses
Order:	Picornavirales
Family:	Secoviridae
Subfamily:	Comovirinae
Genus:	Comovirus
Species:	Cowpea mosaic virus
Synonyms
	Cowpea mosaic virus, SB isolate