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WordNet

hunt rabbits
any of various burrowing animals of the family Leporidae having long ears and short tails; some domesticated and raised for pets or food (同)coney, cony
flesh of any of various rabbits or hares (wild or domesticated) eaten as food (同)hare
spiritual leader of a Jewish congregation; qualified to expound and apply Jewish law

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〈C〉ウサギ;《米》(一般にhareも含めて)ウサギ / 〈U〉ウサギの毛皮(肉) / 〈C〉《英話》(ゴルフ・クリケット,特にテニスの)へたなプレーヤー / ウサギを狩る
ユダヤの律法学者 / ユダヤ教の聖職者;その尊称
ワタオウサギ(綿毛のような白い毛のウサギ;米国産)

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/04/07 09:48:25」(JST)

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Rabbit with Shope papillomavirus infection.

Engraving from Tableau Encyclopedique et Methodique, 1789.

The cottontail rabbit papilloma virus (CRPV), or Shope papilloma virus, is a type I virus under the Baltimore scheme, possessing a nonsegmented dsDNA genome.^[1] The virus was originally separated from horny warts on cottontail rabbits by Richard E. Shope in 1933.^[2] It infects rabbits, causing keratinous carcinomas, typically on or near the animal’s head. These tumors can become large enough that they interfere with the host’s ability to eat, eventually causing starvation.

Shope papilloma virus provided the first mammalian model of a cancer caused by a virus. It takes its name from Shope, who discovered it in the 1930s.^[2] Shope was able to isolate virus particles from tumors on captured animals and use these to inoculate domestic rabbits, which then developed similar tumors.^[3] The virus was sequenced in 1984, showing substantial sequence similarities to HPV1a.^[4] It has been used as a model for human papillomaviruses both before and after this discovery. The most visible example of this role is the HPV vaccine, which was developed based on and incorporating research done using the virus as a model. Similarly, it has been used to investigate antiviral therapies.^[5]

The virus is also a possible source of myths about the jackalope, a rabbit with the horns of an antelope, and related cryptids such as the wolpertinger.^[6]^[7] Stories and illustrations of horned rabbits appear in scientific treatises dating back many years, such as the Tableau encyclopédique et méthodique, from 1789.^[8]

References

^ "Cottontail rabbit papillomavirus" in UniProt
^ ^a ^b Shope RE, Hurst EW (1933). "Infectious papillomatosis of rabbits: with a not on the histopathology". J. Exp. Med. 58 (5): 607–624. doi:10.1084/jem.58.5.607. PMID 19870596.
^ http://www.ratsteachmicro.com/2003_HCOE_PDFs/Papovavirus_Lecture_Outline__2005rev.pdf
^ Giri, Isabelle; Danos, Olivier; Yaniv, Moshe (1985), "Genomic Structure of the Cottontail Rabbit (Shope) Papillomavirus", PNAS 82 (6): 1580–1584, doi:10.1073/pnas.82.6.1580
^ Christensen ND, ND (2005), "Genomic Structure of the Cottontail Rabbit (Shope) Papillomavirus", Antivir Chem Chemother 16 (6): 355–62, PMID 16331841
^ Eberhart, George M. "Mysterious Creatures: Creating A Cryptozoological Encyclopedia." 2005. Journal of Scientific Exploration. Vol. 19, No. 1, pp. 103-113
^ Eberhart, George M. (2002), Mysterious Creatures: A Guide to Cryptozoology 1, ABC-CLIO, pp. 237–238, ISBN 1-57607-283-5
^ "Cottontail rabbit papillomavirus was the first mammalian papillomavirus to be discovered"

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English Journal

Durable immunity to oncogenic human papillomaviruses elicited by adjuvanted recombinant Adeno-associated virus-like particle immunogen displaying L2 17-36 epitopes.

Jagu S1, Karanam B1, Wang JW1, Zayed H2, Weghofer M3, Brendle SA4, Balogh KK4, Tossi KP3, Roden RB5, Christensen ND6.
Vaccine.Vaccine.2015 Oct 13;33(42):5553-63. doi: 10.1016/j.vaccine.2015.09.005. Epub 2015 Sep 15.
Vaccination with the minor capsid protein L2, notably the 17-36 neutralizing epitope, induces broadly protective antibodies, although the neutralizing titers attained in serum are substantially lower than for the licensed L1 VLP vaccines. Here we examine the impact of other less reactogenic adjuvant
PMID 26382603

Model Systems of Human Papillomavirus-Associated Disease.

Doorbar J1.
The Journal of pathology.J Pathol.2015 Oct 12. doi: 10.1002/path.4656. [Epub ahead of print]
Human Papillomaviruses (HPVs) cause a range of serious disease, including the vast majority of cervical cancers, most anal and vulval [AQ: comment from Reviewer, is this acceptable ] cancers and around half of head and neck cancers. They are also responsible for troublesome benign epithelial lesions
PMID 26456009

RNA sequencing analysis identifies novel spliced transcripts but does not indicate quantitative or qualitative changes of viral transcripts during progression of cottontail rabbit papillomavirus-induced tumours.

Probst-Hunczek S1, Jäger G2, Schneider M1, Notz E1, Stubenrauch F1, Iftner T1.
The Journal of general virology.J Gen Virol.2015 Oct;96(10):3083-9. doi: 10.1099/jgv.0.000239. Epub 2015 Jul 9.
Persistent infections with high-risk human papillomaviruses (HPVs) can result in the development of cancer of the cervix uteri and other malignancies. The underlying molecular mechanisms leading to the progression of HPV-induced lesions are, however, not well understood. Cottontail rabbit papillomav
PMID 26297146

Japanese Journal

E2蛋白質をターゲットとしたHPV感染症に対する抗ウイルス薬剤開発への基礎的検討(1 子宮頸癌の発生と進展 : その制御を目指して)

藤井多久磨
日本産科婦人科學會雜誌 54(8), 1036-1046, 2002-08-01
… Integration of human papillomavirus 16 DNA is considered to be a major genetic change in cervical carcinogenesis, and disruption of E2 protein in this process results in the overexpression of E6 and E7 genes. … We therefore focused on the cottontail rabbit papillomavirus (CRPV) because CRPV is available and CRPV can infect into cultured cells. …
NAID 110002185363

Granulocyte-macrophage colony-stimulating factor priming plus papillomavirus E6 DNA vaccination : effects on papilloma formation and regression in the cottontail rabbit papillomavirus-rabbit model

LEACHMAN S. A.
J. Virol. 74, 8700-8708, 2000
NAID 80012258629

The primary target cells of the high-risk cottontail rabbit papillomavirus colocalize with hair follicles stem cells

SCHMITT A
J Virol 70, 1912-1922, 1996
NAID 80008773720

Related Pictures

★リンクテーブル★

リンク元	「ワタウサギパピローマウイルス」
関連記事	「rabbit」「papillomavirus」「rabbit papillomavirus」

「ワタウサギパピローマウイルス」

Shope papilloma virus
Virus classification
Group:	Group I (dsDNA)
Family:	Papillomaviridae
Genus:	Kappapapillomavirus
Species:	Cottontail rabbit papillomavirus