WordNet

impose a blockade on (同)seal off
a war measure that isolates some area of importance to the enemy (同)encirclement
prevents access or progress
obstruct access to (同)block off
blocking entrance to and exit from seaports and harbors; "the blockading ships prevented delivery of munitions"

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1. リウマチ性疾患における生物学的製剤の概要 overview of biologic agents in the rheumatic diseases
2. 臨床的腎移植における研究中の免疫抑制剤およびそのアプローチ investigational immunosuppressive drugs and approaches in clinical kidney transplantation
3. 関節リウマチの病因 pathogenesis of rheumatoid arthritis
4. 移植免疫 transplantation immunobiology
5. 腎機能と腎臓以外の固形臓器移植 renal function and nonrenal solid organ transplantation

IL-15 Induces Alloreactive CD28(-) Memory CD8 T Cell Proliferation and CTLA4-Ig Resistant Memory CD8 T Cell Activation.

Traitanon O1, Gorbachev A, Bechtel JJ, Keslar KS, Baldwin WM 3rd, Poggio ED, Fairchild RL.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.Am J Transplant.2014 Jun;14(6):1277-89. doi: 10.1111/ajt.12719. Epub 2014 May 19.
The presence of CD28(-) memory CD8 T cells in the peripheral blood of renal transplant patients is a risk factor for graft rejection and resistance to CTLA-4Ig induction therapy. In vitro analyses have indicated poor alloantigen-induced CD28(-) memory CD8 T cell proliferation, raising questions abou
PMID 24842641

Impaired ICOSL in human myeloid dendritic cells promotes Th2 responses in patients with allergic rhinitis and asthma.

Shen C1, Hupin C, Froidure A, Detry B, Pilette C.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.Clin Exp Allergy.2014 Jun;44(6):831-41. doi: 10.1111/cea.12308.
BACKGROUND: Myeloid dendritic cells (mDCs) and costimulatory molecules such as ICOSL/B7H2 play a pivotal role in murine experimental asthma, while little is known in human allergic disease. The aim of this study was to characterize the phenotype and ICOSL expression of mDCs from allergic rhinitis pa
PMID 24661627

Dual role of B7 costimulation in obesity-related non-alcoholic steatohepatitis (NASH) and metabolic dysregulation.

Chatzigeorgiou A1, Chung KJ, Garcia-Martin R, Alexaki VI, Klotzsche-von Ameln A, Phieler J, Sprott D, Kanczkowski W, Tzanavari T, Bdeir M, Bergmann S, Cartellieri M, Bachmann M, Nikolakopoulou P, Androutsellis-Theotokis A, Siegert G, Bornstein SR, Muders MH, Boon L, Karalis KP, Lutgens E, Chavakis T.
Hepatology (Baltimore, Md.).Hepatology.2014 May 21. doi: 10.1002/hep.27233. [Epub ahead of print]
The low-grade inflammatory state present in obesity contributes to obesity-related metabolic dysregulation, including non-alcoholic steatohepatitis (NASH) and insulin resistance. Intercellular interactions between immune cells or between immune cells and hepatic parenchymal cells contribute to the e
PMID 24845056

川原敏靖
順天堂医学 56(4), 314-320, 2010
免疫抑制剤の進歩により移植医療は世界に普及し, その成績は飛躍的に向上した. その発展に伴い, 次に問題になるのは免疫抑制剤の非特異的な免疫抑制による感染, 発癌, そして薬剤そのものの副作用である. したがって, 免疫抑制剤投与なしに移植臓器が生着し, さらに感染などに対しての通常の免疫機構が保たれている状態「免疫寛容」の誘導が移植後免疫抑制の最終目標である. 免疫寛容誘導の方法として, 骨髄移 …
NAID 130004712148