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1. 移植免疫 transplantation immunobiology
2. 関節リウマチのためのT細胞標的療法 t cell targeted therapies for rheumatoid arthritis
3. 癌免疫療法の原則 principles of cancer immunotherapy
4. 原発性巣状分節性糸球体硬化症の治療 treatment of primary focal segmental glomerulosclerosis
5. びまん性ループス腎炎や巣状増殖性ループス腎炎の治療と予後 treatment and prognosis of diffuse or focal proliferative lupus nephritis

English Journal

Immune Tolerance Induction against Experimental Autoimmune Encephalomyelitis (EAE) Using A New PLP-B7AP Conjugate that Simultaneously Targets B7/CD28 Costimulatory Signal and TCR/MHC-II Signal.

Badawi AH1, Kiptoo P2, Siahaan TJ2.
Journal of multiple sclerosis.J Mult Scler (Foster City).2015 Dec;2(1). pii: 1000131.
Most of the current therapies used in the treatment of multiple sclerosis (MS) are either ineffective or have adverse side effects. As such, there is a need to develop better therapies that specifically target myelin-specific aberrant immune cells involved in CNS inflammation without compromising th
PMID 26140285

Curti BD1, Urba WJ2.
Molecular immunology.Mol Immunol.2015 Oct;67(2 Pt A):18-27. doi: 10.1016/j.molimm.2015.01.025. Epub 2015 Mar 6.
The concept of using immunotherapy to treat melanoma has existed for decades. The rationale comes from the knowledge that many patients with melanoma have endogenous immune responses against their tumor cells and clinically meaningful tumor regression can be achieved in a minority of patients using
PMID 25746916

Differences in B7 and CD28 family gene expression in the peripheral blood between newly diagnosed young-onset and adult-onset type 1 diabetes patients.

Pruul K1, Kisand K1, Alnek K1, Metsküla K1, Reimand K1, Heilman K2, Peet A3, Varik K4, Peetsalu M4, Einberg Ü5, Tillmann V3, Uibo R6.
Molecular and cellular endocrinology.Mol Cell Endocrinol.2015 Sep 5;412:265-71. doi: 10.1016/j.mce.2015.05.012. Epub 2015 May 14.
Type-1 diabetes (T1D) is a heterogeneous autoimmune disease, and there are pathogenetic differences between young- and adult-onset T1D patients. We hypothesized that the expressions of genes involved in costimulatory immune system pathways in peripheral blood are differently regulated in young- and
PMID 25980680

CTLA-4 Protects against Angiotensin II-Induced Abdominal Aortic Aneurysm Formation in Mice

Amin Hilman Zulkifli,Sasaki Naoto,Yamashita Tomoya,Mizoguchi Taiji,Hayashi Tomohiro,Emoto Takuo,Matsumoto Takuya,Yoshida Naofumi,Tabata Tokiko,Horibe Sayo,Kawauchi Shoji,Rikitake Yoshiyuki,Hirata Ken-ichi
Scientific Reports (9), 8065, 2019-05-30
… These protective effects were associated with a decreased number of effector CD4(+) T cells and the downregulated expression of costimulatory molecules CD80 and CD86, ligands for CTLA-4, on CD11c(+) dendritic cells in lymphoid tissues. …
NAID 120006645700

Hosoe Yuhi,Numoto Nobutaka,Inaba Satomi,Ogawa Shuhei,Morii Hisayuki,Abe Ryo,Ito Nobutoshi,Oda Masayuki
Biophysics and Physicobiology 16(0), 80-88, 2019
… Binding of Grb2 SH2 to the cytoplasmic region of CD28, phosphorylated Tyr (pY) containing the peptide motif pY-X-N-X, is required for costimulatory signaling in T cells. …
NAID 130007602940

Selective DNAM-1 expression on small peritoneal macrophages contributes to CD4+ T cell costimulation

Takenaka Eri,Van Vo Anh,Yamashita-Kanemaru Yumi,Shibuya Akira,Shibuya Kazuko,渋谷彰,渋谷和子
Scientific reports (8), 15180, 2018-10
… We propose that SPMs are functionally distinct from LPMs, and DNAM-1 plays a costimulatory role in antigen presentation by SPMs. …
NAID 120006542251