補体レセプター
WordNet
- make complete or perfect; supply what is wanting or form the complement to; "I need some pepper to complement the sweet touch in the soup"
- a complete number or quantity; "a full complement"
- one of a series of enzymes in the blood serum that are part of the immune response
- something added to complete or embellish or make perfect; "a fine wine is a perfect complement to the dinner"; "wild rice was served as an accompaniment to the main dish" (同)accompaniment
- number needed to make up a whole force; "a full complement of workers" (同)full complement
- a word or phrase used to complete a grammatical construction
- either of two parts that mutually complete each other
- a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
PrepTutorEJDIC
- (あるものを完全にするため)(…を)補う物(事)《+『of』+『名』》 / 補語(文法で文の成分の一つ) / (必要な)全数,全量;(船の)定員 / …を補足する,補う
- =sense organ / 受信装置
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/07/17 15:23:18」(JST)
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A complement receptor is a receptor of the complement system, a part of the mediated innate immune system. Complement receptors are responsible for detecting pathogens by mechanisms not mediated by antibodies. Complement activity is not antigen sensitive, but can be triggered by specific antigens. Therefore complement (a group of proteins in the serum that help achieve phagocytosis and lysis of antigens) is also part of the humoral immune system.
Contents
- 1 Complement receptors
- 2 Clinical significance
- 3 See also
- 4 References
- 5 External links
Complement receptors
Types include:
CR # |
Name |
CD |
CR1 |
- |
CD35 |
CR2 |
- |
CD21 |
CR3 |
Macrophage-1 antigen or "integrin alphaMbeta2" |
CD11b+CD18 |
CR4 |
Integrin alphaXbeta2 or "p150,95" |
CD11c+CD18 |
- |
C3a receptor |
- |
- |
C5a receptor |
CD88 |
Clinical significance
Defects in these receptors can be associated with disease.[1]
See also
References
- ^ "Complement Receptor Deficiency: eMedicine Dermatology". Retrieved 2010-12-07.
External links
- Complement receptors at the US National Library of Medicine Medical Subject Headings (MeSH)
Proteins: complement system (C, L, A)
|
|
Activators/enzymes |
Early |
- A: Factor B
- Factor D
- Factor P/Properdin
|
|
Middle |
- C3-convertase
- C5-convertase
|
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Late |
|
|
|
Inhibitors |
- CLA: C1-inhibitor
- Decay-accelerating factor/CD59
- Factor I
|
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Complement receptors |
- CR1
- CR2
- CR3
- CR4
- CD11b/CD11c/CD18
- Anaphylatoxin
|
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Index of the immune system
|
|
Description |
- Physiology
- cells
- autoantigens
- autoantibodies
- complement
- surface antigens
- IG receptors
|
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Disease |
- Allergies
- Immunodeficiency
- Immunoproliferative immunoglobulin disorders
- Hypersensitivity and autoimmune disorders
- Neoplasms and cancer
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Treatment |
- Procedures
- Drugs
- antihistamines
- immunostimulants
- immunosuppressants
- monoclonal antibodies
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Innate immune system: Pattern recognition receptors
|
|
Membrane-bound_PRRs |
- Toll-like receptor
- Mannose receptor
- Formyl peptide receptor
- Scavenger receptor
|
|
Cytoplasmic_PRRs |
- Toll-like receptor
- NOD-like receptor
- RIG-I-like receptor
- Scavenger receptor
|
|
Secreted_PRRs |
- Complement receptor
- Collectin
|
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Other/ungrouped |
- Immunophilins (Cyclophilin)
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Index of cells from bone marrow
|
|
Description |
- Immune system
- Cells
- Physiology
- coagulation
- proteins
- granule contents
- colony-stimulating
- heme and porphyrin
|
|
Disease |
- Red blood cell
- Monocyte and granulocyte
- Neoplasms and cancer
- Histiocytosis
- Symptoms and signs
- Blood tests
|
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Treatment |
- Transfusion
- Drugs
- thrombosis
- bleeding
- other
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UpToDate Contents
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- 1. 補体系の制御因子および受容体 regulators and receptors of the complement system
- 2. 運動以外の好中球機能 neutrophil functions other than movement
- 3. 補体系の遺伝性疾患 inherited disorders of the complement system
- 4. 肥満細胞:表面受容体とシグナル伝達 mast cells surface receptors and signal transduction
- 5. 好中球運動の決定要因 determinants of neutrophil movement
English Journal
- Novel roles for complement receptors in T cell regulation and beyond.
- Kemper C, Köhl J.SourceDivision of Transplant Immunology and Mucosal Biology, MRC Centre for Transplantation, King's College London, Guy's Hospital, London SE1 9RT, UK. Electronic address: claudia.kemper@kcl.ac.uk.
- Molecular immunology.Mol Immunol.2013 Dec 15;56(3):181-90. doi: 10.1016/j.molimm.2013.05.223. Epub 2013 Jun 22.
- Complement receptors are expressed on cells of the innate and the adaptive immune system. They play important roles in pathogen and danger sensing as they translate the information gathered by complement fluid phase sensors into cellular responses. Further, they control complement activation on viab
- PMID 23796748
- Autoantibodies against complement components and functional consequences.
- Dragon-Durey MA, Blanc C, Marinozzi MC, van Schaarenburg RA, Trouw LA.SourceINSERM UMRS 872, Cordeliers Research Center, Paris, France; Paris Descartes University, Paris, France; Laboratoire d'Immunologie, Hôpital Européen Georges Pompidou, Paris, France.
- Molecular immunology.Mol Immunol.2013 Dec 15;56(3):213-21. doi: 10.1016/j.molimm.2013.05.009. Epub 2013 Jun 20.
- The complement system represents a major component of our innate immune defense. Although the physiological contribution of the complement system is beneficial, it can cause tissue damage when inappropriately activated or when it is a target of an autoantibody response. Autoantibodies directed again
- PMID 23790637
- Complement activation is critical for placental ischemia-induced hypertension in the rat.
- Lillegard KE, Johnson AC, Lojovich SJ, Bauer AJ, Marsh HC, Gilbert JS, Regal JF.SourceDepartment of Biomedical Sciences, University of Minnesota Medical School Duluth, Duluth, MN 55812, USA. lille067@umn.edu
- Molecular immunology.Mol Immunol.2013 Nov;56(1-2):91-7. doi: 10.1016/j.molimm.2013.04.009. Epub 2013 May 15.
- Preeclampsia is a major obstetric problem defined by new-onset hypertension and proteinuria associated with compromised placental perfusion. Although activation of the complement system is increased in preeclampsia compared to normal pregnancy, it remains unclear whether excess complement activation
- PMID 23685261
Japanese Journal
- The Quest for the Adult Cardiac Stem Cell
- Noseda Michela,Abreu-Paiva Marta,Schneider Michael D.
- Circulation Journal 79(7), 1422-1430, 2015
- … Approaches under study to augment cardiac repair complement each other, and encompass grafting cells of diverse kinds, restarting the cell cycle in post-mitotic ventricular myocytes, reprogramming non-myocytes, and exploiting the dormant progenitor/stem cells that lurk within the adult heart. …
- NAID 130005083952
- FcγRIIB Gene Polymorphisms Are Associated with Disease Risk and Clinical Manifestations of Systemic Lupus Erythematosus in Koreans
- Jeon Ja-Young,Kim Keon-Young,Kim Bong-Sik,Jung Ju-Yang,Kim Hyoun-Ah,Suh Chang-Hee
- The Tohoku Journal of Experimental Medicine 236(3), 185-191, 2015
- … We have screened single nucleotide polymorphisms (SNPs) in one of FcγR gene, FcγRIIB, which is the only inhibitory receptor, after considering gene map and reported SNPs. … Among 5 haplotypes, the frequency of decreased complement was significantly lower in SLE patients with haplotype 1 [TTG] (p = 0.045). …
- NAID 130005077912
- The Quest for the Adult Cardiac Stem Cell
- Noseda Michela,Abreu-Paiva Marta,Schneider Michael D.
- Circulation Journal advpub(0), 2015
- … Approaches under study to augment cardiac repair complement each other, and encompass grafting cells of diverse kinds, restarting the cell cycle in post-mitotic ventricular myocytes, reprogramming non-myocytes, and exploiting the dormant progenitor/stem cells that lurk within the adult heart. …
- NAID 130005076075
Related Links
- A complement receptor is a receptor of the complement system, a part of the mediated innate immune system. Complement receptors are responsible for detecting pathogens by mechanisms not mediated by antibodies. Complement activity is ...
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★リンクテーブル★
[★]
- 英
- complement receptor
- 関
- 補体レセプター
[★]
- 英
- complement receptor
- 関
- 補体
[★]
- 補って完全にする物、補完物。(免疫)補体
- (必要な)全数、善良