Transfusion.Transfusion.2015 Dec 12. doi: 10.1111/trf.13435. [Epub ahead of print]
BACKGROUND: The coinfusion of haploidentical CD34+ selected peripheral blood stem cell products with umbilical cord blood (UCB) provides early neutrophil recovery, long-term UCB engraftment, and a lower incidence of graft-versus-host disease; however, this complex transplant presents a scheduling ch
Toll-like receptor 4-induced endoplasmic reticulum stress contributes to impairment of vasodilator action of insulin.
Kim JA1, Jang HJ2, Hwang DH3.
American journal of physiology. Endocrinology and metabolism.Am J Physiol Endocrinol Metab.2015 Nov 1;309(9):E767-76. doi: 10.1152/ajpendo.00369.2015. Epub 2015 Sep 8.
Impairment of vasodilator action of insulin is associated with endothelial dysfunction and insulin resistance. Activation of Toll-like receptor 4 (TLR4) induces proinflammatory response and endoplasmic reticulum (ER) stress. Saturated fatty acids (SFA) activate TLR4, which induces ER stress and endo
Anxiogenic and Stressor Effects of the Hypothalamic Neuropeptide RFRP-3 Are Overcome by the NPFFR Antagonist GJ14.
Kim JS1, Brownjohn PW1, Dyer BS1, Beltramo M1, Walker CS1, Hay DL1, Painter GF1, Tyndall JD1, Anderson GM1.
Endocrinology.Endocrinology.2015 Nov;156(11):4152-62. doi: 10.1210/en.2015-1532. Epub 2015 Aug 10.
RFamide-related peptide-3 (RFRP-3) is a recently discovered neuropeptide that has been proposed to play a role in the stress response. We aimed to elucidate the role of RFRP-3 and its receptor, neuropeptide FF (NPFF1R), in modulation of stress and anxiety responses. To achieve this, we characterized
J Clin Oncol. 2000 Jan;18(2):307-16. Rapid hematopoietic recovery after coinfusion of autologous-blood stem cells and culture-expanded marrow mesenchymal stem cells in advanced breast cancer patients receiving high-dose ...
Bone Marrow Transplant. 2011 Feb;46(2):200-7. doi: 10.1038/bmt.2010.87. Epub 2010 Apr 19. Co-infusion of ex vivo-expanded, parental MSCs prevents life- threatening acute GVHD, but does not reduce the risk of graft failure in pediatric ...