Soluble Amyloid-β42 Stimulates Glutamate Release through Activation of the α7 Nicotinic Acetylcholine Receptor.
Hascup KN1, Hascup ER1,2.
Journal of Alzheimer's disease : JAD.J Alzheimers Dis.2016 May 3. [Epub ahead of print]
Alzheimer's disease (AD) is an age-related neurodegenerative disorder characterized by progressive memory loss and hippocampal atrophy. Soluble amyloid-β (Aβ)42 and plaque accumulation is implicated as the neurotoxic species in this disorder; however, at physiological concentrations (pM-nM), Aβ42
Electroacupuncture Enhances the Antiallodynic and Antihyperalgesic Effects of Milnacipran in Neuropathic Rats.
Li C1, Ji BU, Kim Y, Lee JE, Kim NK, Kim ST, Koo S.
Anesthesia and analgesia.Anesth Analg.2016 May;122(5):1654-62. doi: 10.1213/ANE.0000000000001212.
BACKGROUND: Milnacipran, a selective serotonin/norepinephrine-reuptake inhibitor, has been shown to elicit a beneficial effect in various models of neuropathic pain. Previously, we reported that repetitive electroacupuncture (EA) significantly ameliorates neuropathic pain induced by L5 spinal nerve
The Journal of antimicrobial chemotherapy.J Antimicrob Chemother.2016 Apr 18. pii: dkw095. [Epub ahead of print]
OBJECTIVES: T-2307, a novel arylamidine, exhibits potent broad-spectrum activities against pathogenic fungi, particularly Candida albicans. We previously reported that T-2307 uptake was mainly mediated by a saturable high-affinity carrier at the MIC for C. albicans. Since we hypothesized that the po
Anesthesiology. 2009 Jul;111(1):127-37. doi: 10.1097/ALN.0b013e3181a915e7. Coapplication of lidocaine and the permanently charged sodium channel blocker QX-314 produces a long-lasting nociceptive blockade in rodents. Binshtok AM ...