- 同時投与する
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- 1. 成人の単極性うつ病：抗不安薬による治療 unipolar depression in adults treatment with anxiolytics
- 2. 後天性C1インヒビター欠損症：管理および予後 acquired c1 inhibitor deficiency management and prognosis
- 3. ケタミン中毒 ketamine poisoning
English Journal
- Moving From Policy to Implementation: A Methodology and Lessons Learned to Determine Eligibility for Healthy Food Financing Projects.
- Harries C1, Koprak J, Young C, Weiss S, Parker KM, Karpyn A.Author information 1National Campaign for Healthy Food Access (Ms Harries and Koprak), Research, Evaluation and Consulting (Mss Young, Weiss and Dr Karpyn), The Food Trust, Philadelphia, Pennsylvania; and Prevention Research Center at Tulane University, New Orleans, Louisiana (Dr Parker). Dr Parker is now Executive Director, Market Umbrella, New Orleans, Louisiana.AbstractPublic health obesity prevention experts have recently emphasized a policy systems and environmental change approach. Absent, however, are studies describing how practitioners transition from policy adoption to implementation. In the realm of food policy, financing programs to incentivize healthy food retail development in communities classified as "underserved" are underway at the local, state, and national levels. Implementing these policies requires a clear definition of eligibility for program applicants and policy administrators. This article outlines a methodology to establish eligibility for healthy food financing programs by describing the work of The Food Trust to coadminister programs in 3 distinct regions. To determine program eligibility, qualitative assessments of community fit are needed and national data sources must be locally verified. Our findings have broad implications for programs that assess need to allocate limited public/private financing resources.This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License, where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially.
- Journal of public health management and practice : JPHMP.J Public Health Manag Pract.2014 Mar 3. [Epub ahead of print]
- Public health obesity prevention experts have recently emphasized a policy systems and environmental change approach. Absent, however, are studies describing how practitioners transition from policy adoption to implementation. In the realm of food policy, financing programs to incentivize healthy fo
- PMID 24594793
- Impact of lipopolysaccharide-induced inflammation on the disposition of the aminocephalosporin cefadroxil.
- Huh Y1, Keep RF, Smith DE.Author information 1Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michigan, USA.AbstractThe purpose of this study was to determine if the disposition of cefadroxil, an α-amino-containing β-lactam antibiotic, changes during lipopolysaccharide (LPS)-induced acute inflammation. Six hours after LPS or saline treatment, mice received 1 nmol/g cefadroxil intravenously along with inulin for glomerular filtration rate (GFR) determination. Serial blood samples, along with tissue and urine samples, were collected at predetermined time points. In order to determine inflammation-induced changes in GFR, renal tubular secretion, and reabsorption, it was necessary to coadminister 70 mg/kg probenecid. Changes in the expression of the mRNA of transporters involved in cefadroxil disposition in the kidneys and choroid plexus were also investigated 6 h after LPS treatment. The results demonstrated marked increases in blood, cerebrospinal fluid, and tissue cefadroxil concentrations with LPS treatment. Tissue-to-blood concentration ratios were decreased by 4.6-fold in the choroid plexus and by 2.5-fold in the kidneys during LPS-induced inflammation. Renal, but not choroid plexus, mRNA expression of peptide transporter 2, organic-anion transporter 1 (OAT1), OAT3, and multidrug resistance-associated protein 4 was mildly reduced in LPS-treated mice. The renal clearance of cefadroxil was substantially decreased by LPS treatment (3-fold). GFR was also reduced by 3-fold in LPS-treated mice, but no significant differences in the fractional reabsorption of cefadroxil and renal secretion once normalized by GFR were observed. These findings demonstrated that LPS-induced inflammation has a dramatic effect on the renal excretion of cefadroxil. It appears that changes in transporter expression played a minor role during LPS treatment but that renal dysfunction, associated with GFR reduction, was responsible for the substantial increase in plasma cefadroxil concentration-time profiles.
- Antimicrobial agents and chemotherapy.Antimicrob Agents Chemother.2013 Dec;57(12):6171-8. doi: 10.1128/AAC.01497-13. Epub 2013 Sep 30.
- The purpose of this study was to determine if the disposition of cefadroxil, an α-amino-containing β-lactam antibiotic, changes during lipopolysaccharide (LPS)-induced acute inflammation. Six hours after LPS or saline treatment, mice received 1 nmol/g cefadroxil intravenously along with inulin for
- PMID 24080658
- Nanoparticle-mediated codelivery of myelin antigen and a tolerogenic small molecule suppresses experimental autoimmune encephalomyelitis.
- Yeste A1, Nadeau M, Burns EJ, Weiner HL, Quintana FJ.Author information 1Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.AbstractThe immune response is normally controlled by regulatory T cells (Tregs). However, Treg deficits are found in autoimmune diseases, and therefore the induction of functional Tregs is considered a potential therapeutic approach for autoimmune disorders. The activation of the ligand-activated transcription factor aryl hydrocarbon receptor by 2-(1'H-indole-3'-carbonyl)-thiazole-4-carboxylic acid methyl ester (ITE) or other ligands induces dendritic cells (DCs) that promote FoxP3(+) Treg differentiation. Here we report the use of nanoparticles (NPs) to coadminister ITE and a T-cell epitope from myelin oligodendrocyte glycoprotein (MOG)(35)(-55) to promote the generation of Tregs by DCs. NP-treated DCs displayed a tolerogenic phenotype and promoted the differentiation of Tregs in vitro. Moreover, NPs carrying ITE and MOG(35-55) expanded the FoxP3(+) Treg compartment and suppressed the development of experimental autoimmune encephalomyelitis, an experimental model of multiple sclerosis. Thus, NPs are potential new tools to induce functional Tregs in autoimmune disorders.
- Proceedings of the National Academy of Sciences of the United States of America.Proc Natl Acad Sci U S A.2012 Jul 10;109(28):11270-5. doi: 10.1073/pnas.1120611109. Epub 2012 Jun 27.
- The immune response is normally controlled by regulatory T cells (Tregs). However, Treg deficits are found in autoimmune diseases, and therefore the induction of functional Tregs is considered a potential therapeutic approach for autoimmune disorders. The activation of the ligand-activated transcrip
- PMID 22745170
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- co·ad·min·is·tra·tion. noun \ˌkō-əd-ˌmin-ə-ˈstrā-shən ad-\. Definition of COADMINISTRATION. : the administration of two or more drugs together. —co·ad ·min·is·ter \-ˈmin-ə-stər\ transitive verb. Learn More About. Dictionary: Definition of ...
- [edit] Verb. coadminister (third-person singular simple present coadministers, present participle coadministering, simple past and past participle coadministered). (transitive) To administer (a drug, etc.) along with another material.
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| リンク元 | 「coapply」「co-apply」「co-administer」「同時投与」「coapplication」 |
「coapply」
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- 関
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「co-apply」
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- 関
- co-administer、co-administration、co-application、coadminister、coadministration、coapplication、coapply
「co-administer」
- 同時投与する
「同時投与」
- 英
- coadministration、co-administration、coapplication、co-application、coadminister、co-administer、coapply、co-apply