WordNet
- the localized death of living cells (as from infection or the interruption of blood supply) (同)mortification, gangrene, sphacelus
PrepTutorEJDIC
- 壊疽(えそ)
- 凝固,凝結
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/03/26 04:31:24」(JST)
[Wiki en表示]
Coagulative necrosis is a type of accidental cell death typically caused by ischemia or infarction. In coagulative necrosis the architecture of dead tissue is preserved for at least a couple of days.[1] It is believed that the injury denatures structural proteins as well as lysosomal enzymes thus blocking the proteolysis of the damaged cells. The lack of lysosomal enzymes allows it to maintain a "coagulated" morphology for some time. Like most types of necrosis if enough viable cells are present around the affected area regeneration will usually occur.
Coagulative necrosis can also be induced by high local temperature; it is a desired effect of treatments such as high intensity focused ultrasound applied to cancerous cells.[2]
Contents
- 1 Causes
- 2 Pathology
- 2.1 Macroscopic
- 2.2 Microscopic
- 3 Regeneration
- 4 References
- 5 External links
Causes
Coagulative necrosis is most commonly caused by conditions that do not involve severe trauma, toxins or an acute or chronic immune response. The lack of oxygen (hypoxia) causes cell death in a localised area which is perfused by blood vessels failing to deliver primarily oxygen, but also other important nutrients. It is important to note that while ischemia in most tissues of the body will cause coagulative necrosis, in the central nervous system ischemia causes liquefactive necrosis, as there is very little structural framework in neural tissue.
Pathology
Macroscopic
The macroscopic appearance of an area of coagulative necrosis is a pale segment of tissue contrasting against surrounding well vascularised tissue and is dry on cut surface. The tissue may later turn red due to inflammatory response. The surrounding surviving cells can aid in regeneration of the affected tissue unless they are stable or permanent.
Microscopic
The microscopic anatomy shows a lighter staining tissue (when stained with H&E) containing no nuclei with very little structural damage, giving the appearance often quoted as 'ghost cells'. The decreased staining is due to digested nuclei which no longer show up as dark purple when stained with hematoxylin, and removed cytoplasmic structures giving reduced amounts of intracellular protein, reducing the usual dark pink staining cytoplasm with eosin.
Regeneration
As the majority of the structural remnants of the necrotic tissue remains, labile cells adjacent to the affected tissue will replicate and replace the cells which have been killed during the event. Labile cells are constantly undergoing mitosis and can therefore help reform the tissue, whereas nearby stable and permanent cells (e.g. neurons and cardiomyocytes) do not undergo mitosis and will not replace the tissue affected. Fibroblasts will also migrate to the affected area depositing fibrous tissue producing fibrosis or scarring in areas where viable cells do not replicate and replace tissue.
References
- ^ Robbins and Cotran: Pathologic Basis of Disease, 8th Ed. 2010. Pg. 15
- ^ F. Wu; Z.-B. Wang; Y.-De Cao; W.-Z. Chen; J. Bai; J.-Z. Zou; H. Zhu (December 2003). "A randomised clinical trial of high-intensity focused ultrasound ablation for the treatment of patients with localised breast cancer". British journal of cancer. 89 (12): 2227–2233. doi:10.1038/sj.bjc.6601411. PMC 2395272. PMID 14676799.
External links
- http://library.med.utah.edu/WebPath/CINJHTML/CINJ016.html
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Medicine: Pathology
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| Principles of pathology |
- Disease
- Infection
- Neoplasia
- Etiology
- Pathogenesis
- Hemodynamics
- Inflammation
- Cell damage
- Wound healing
- Cellular adaptation
- Atrophy
- Hypertrophy
- Hyperplasia
- Dysplasia
- Metaplasia
- Squamous
- Glandular
- Cell death
- Necrosis
- Coagulative necrosis
- Liquefactive necrosis
- Gangrenous necrosis
- Caseous necrosis
- Fat necrosis
- Fibrinoid necrosis
- Programmed cell death
- Apoptosis
- Pyknosis
- Karyorrhexis
- Karyolysis
- Accumulations
- pigment
- Hemosiderin
- Lipochrome/Lipofuscin
- Melanin
- Steatosis
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| Anatomical pathology |
- Surgical pathology
- Cytopathology
- Autopsy
- Molecular pathology
- Forensic pathology
- Oral and maxillofacial pathology
- Gross examination
- Histopathology
- Immunohistochemistry
- Electron microscopy
- Immunofluorescence
- Fluorescence in situ hybridization
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| Clinical pathology |
- Clinical chemistry
- Hematopathology
- Transfusion medicine
- Medical microbiology
- Diagnostic immunology
- Immunopathology
- Enzyme assay
- Mass spectrometry
- Chromatography
- Flow cytometry
- Blood bank
- Microbiological culture
- Serology
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| Specific conditions |
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UpToDate Contents
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English Journal
- A 26-week repeated dose toxicity study of Xian-ling-gu-bao in Sprague-Dawley rats.
- Cheng Y, Liu Y, Wang H, Li J, Ren J, Zhu L, Gong L.SourceDepartment of Pharmacology and Chemical Biology, Institute of Medical Sciences, Shanghai Jiao Tong University School of Medicine, China; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
- Journal of ethnopharmacology.J Ethnopharmacol.2013 Jan 9;145(1):85-93. doi: 10.1016/j.jep.2012.09.055. Epub 2012 Oct 30.
- ETHNOPHARMACOLOGICAL RELEVANCE: Xian-ling-gu-bao (XLGB) is a traditional Chinese prescription commonly used to treat osteoporosis, osteoarthritis, aseptic bone necrosis, climacteric syndrome, and bone fracture. However, there is limited toxicological information available on XLGB in preclinical anim
- PMID 23123261
- Enhanced binding of tissue factor-microparticles to collagen-IV and fibronectin leads to increased tissue factor activity in vitro.
- Ettelaie C, Collier ME, Mei MP, Xiao YP, Maraveyas A.SourceDr. Camille Ettelaie, Biomedical Section, Department of Biological Sciences, University of Hull, Cottingham Road, Hull, HU6 7RX, UK, Tel.: +44 1482 465528, Fax: +44 1482 465458, E-mail: C.Ettelaie@hull.ac.uk.
- Thrombosis and haemostasis.Thromb Haemost.2013 Jan 8;109(1):61-71. doi: 10.1160/TH12-05-0279. Epub 2012 Nov 15.
- The role of tissue factor (TF)-containing microparticles in clot propagation has been established, but the ability of circulating microparticles to initiate coagulation has been disputed. However, TF-bearing microparticles, particularly endothelial-microparticles generated during disease, may intera
- PMID 23152142
Japanese Journal
- Idiopathic Adult Intussusception : A Case Report
- Shimizu Takahiro,Kobayashi Naoyuki,Saito Junichi [他]
- 北関東医学 62(2), 139-141, 2012-05
- … Pathological examination of resectedspecimen showed marked congestion and hemorrhage with coagulation necrosis. …
- NAID 40019329391
- Progressive tentorial cavernous malformation
- Furuta Takuya,Nakada Mitsutoshi,Watanabe Takuya,Hayashi Yutaka,Hamada Jun-ichiro
- Surgical Neurology International 3(1), 92934, 2012-01-01
- … Postoperative MR imaging showed remarkable mass reduction and central necrosis of the lesion. … Coagulation of the feeding artery was not sufficient to control the lesion. …
- NAID 120004754692
Related Links
- Coagulative necrosis is a type of accidental cell death typically caused by ischemia or infarction. It is characterized by the 'ghostly' appearance of cells under light microscopy in the affected area of tissue. In coagulative necrosis the ...
- necrosis /ne·cro·sis/ (nĕ-kro´sis) pl. necro´ses [Gr.] the morphological changes indicative of cell death caused by progressive enzymatic degradation; it may affect groups of cells or part of a structure or an organ.
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- 英
- coagulation necrosis
- 関
- 壊死