WordNet

a silvery soft waxy metallic element of the alkali metal group; occurs abundantly in natural compounds (especially in salt water); burns with a yellow flame and reacts violently in water; occurs in sea water and in the mineral halite (rock salt) (同)Na, atomic number 11

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/06/27 23:01:47」(JST)

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Changes in the use of broad-spectrum antibiotics after cefepime shortage: a time series analysis.

Plüss-Suard C, Pannatier A, Ruffieux C, Kronenberg A, Mühlemann K, Zanetti G.SourceAddress correspondence to Catherine Plüss-Suard, Catherine.Pluss@chuv.ch.
Antimicrobial agents and chemotherapy.Antimicrob Agents Chemother.2012 Feb;56(2):989-94. Epub 2011 Nov 28.
The original cefepime product was withdrawn from the Swiss market in January 2007 and replaced by a generic 10 months later. The goals of the study were to assess the impact of this cefepime shortage on the use and costs of alternative broad-spectrum antibiotics, on antibiotic policy, and on resista
PMID 22123703

New insights into meticillin-resistant Staphylococcus aureus (MRSA) pathogenesis, treatment and resistance.

Gould IM, David MZ, Esposito S, Garau J, Lina G, Mazzei T, Peters G.SourceDepartment of Medical Microbiology, Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB25 2ZN, UK.
International journal of antimicrobial agents.Int J Antimicrob Agents.2012 Feb;39(2):96-104. Epub 2011 Dec 21.
Meticillin-resistant Staphylococcus aureus (MRSA) remains one of the principal multiply resistant bacterial pathogens causing serious healthcare-associated and community-onset infections. This paper reviews recent studies that have elucidated the virulence strategies employed by MRSA, key clinical t
PMID 22196394

Antimicrobial Susceptibility of Gram-Negative Pathogens Isolated from Patients with Complicated Intra-Abdominal Infections in South African Hospitals (SMART Study 2004-2009): Impact of the New Carbapenem Breakpoints.

Brink AJ, Botha RF, Poswa X, Senekal M, Badal RE, Grolman DC, Richards GA, Feldman C, Boffard KD, Veller M, Joubert I, Pretorius J.Source1 Department of Clinical Microbiology, Ampath National Laboratory Services, Milpark Hospital , Parktown, Johannesburg, South Africa .
Surgical infections.Surg Infect (Larchmt).2012 Jan 5. [Epub ahead of print]
Abstract Background: The Study for Monitoring Antimicrobial Resistance Trends (SMART) follows trends in resistance among aerobic and facultative anaerobic gram-negative bacilli (GNB) isolated from complicated intra-abdominal infections (cIAIs) in patients around the world. Methods: During 2004-2
PMID 22220506

奥野祐次
PAIN RESEARCH 29(4), 233-241, 2014
… We hypothesized that abnormal neovessels also play an important role in nighttime shoulder pain with other conditions as well as adhesive capsulitis and that TAME can relieve pain. Material and Methods: TAME using imipenem ⁄ cilastatin sodium as an embolic agent proceeded to seventeen shoulders in sixteen patients, including adhesive capsulitis (n=6), subacromial impingement syndrome (n=7), rotator cuff tear without surgical indication (n=2), stiff shoulder (n=1), and chronic pain post scapula fracture (n=1). …
NAID 130004839647

山崎繁通,石倉宏恭,紙谷孝則,田中潤一,西澤新也,高良真一,東原秀行,岩下英之,坂暁子,吉兼誠,向坂彰太郎
日本腹部救急医学会雑誌 = Journal of abdominal emergency medicine 31(5), 705-712, 2011-07-31
… 抗菌薬は一般にimipenem/cilastatin sodium（以下，IPM/CS）が多く使用されているが，他の抗菌薬との比較検討はほとんどなされていない現状にある。 …
NAID 10029879944

徳山博文,鷲田直輝,脇野修 [他],原義和,藤村慶子,伊藤新,上山菜穂,乃村元子,林晃一,伊藤裕
日本透析医学会雑誌 = Journal of Japanese Society for Dialysis Therapy 43(8), 649-653, 2010-08-28
… 29日外来受診時は血液検査所見に異常所見はなかったが，5月30日より腹痛出現，徐々に症状増悪し，6月5日当院を受診し腹膜炎疑いにて緊急入院した．抗生剤の点滴静注（ceftazidime hydrate（CAZ）1 g/日，cefazolin sodium（CEZ）1 g/日，vancomycin hydrochloride（VCM）1 g/日）および腹腔内投与CAZ 1 g/日，CEZ 1 g/日）を施行したが，症状改善せずCAPD排液細胞数は540/μLから940/μLへ上昇した．第5病日，排液細菌培養にて複数菌が判明し，第6 …
NAID 10026622490

リンク元	「シラスタチン」「シラスタチンナトリウム」

Cilastatin
Systematic (IUPAC) name
	(Z)-7-[(2R)-2-Amino-3-hydroxy-3-oxopropyl]sulfanyl-2-{[(1S)-2,2-dimethylcyclopropanecarbonyl]amino}hept-2-enoic acid
Clinical data
AHFS/Drugs.com	International Drug Names
MedlinePlus	a686013
Routes of; administration	IV
Identifiers
CAS Registry Number	82009-34-5
ATC code	J01DH51 (combination with imipenem)
PubChem	CID: 5280454
IUPHAR/BPS	5166
DrugBank	DB01597
ChemSpider	4940183
UNII	141A6AMN38
KEGG	D07698
ChEBI	CHEBI:3697
ChEMBL	CHEMBL766
Chemical data
Formula	C16H26N2O5S
Molecular mass	358.454 g/mol
	SMILES O=C(N\C(=C/CCCCSC[C@@H](C(=O)O)N)C(=O)O)[C@H]1CC1(C)C ;
	InChI InChI=1S/C16H26N2O5S/c1-16(2)8-10(16)13(19)18-12(15(22)23)6-4-3-5-7-24-9-11(17)14(20)21/h6,10-11H,3-5,7-9,17H2,1-2H3,(H,18,19)(H,20,21)(H,22,23)/b12-6-/t10-,11+/m1/s1 ; Key:DHSUYTOATWAVLW-WFVMDLQDSA-N ;
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