WordNet

slight or limited; especially in degree or intensity or scope; "a series of death struggles with small time in between"
a garment size for a small person
the slender part of the back
limited or below average in number or quantity or magnitude or extent; "a little dining room"; "a little house"; "a small car"; "a little (or small) group" (同)little
have fine or very small constituent particles; "a small misty rain"
on a small scale; "think small"
being long-lasting and recurrent or characterized by long suffering; "chronic indigestion"; "a chronic shortage of funds"; "a chronic invalid"
of long duration; "chronic money problems" (同)continuing
habitual; "a chronic smoker" (同)inveterate
malignant neoplasm of blood-forming tissues; characterized by abnormal proliferation of leukocytes; one of the four major types of cancer (同)leukaemia, leucaemia, cancer of the blood
of or relating to lymphocytes; "lymphocytic leukemia"
a neoplasm of lymph tissue that is usually malignant; one of the four major types of cancer

PrepTutorEJDIC

(大きさが)『小さい』,小形の;(量が)『少ない』,わずかな / 『取るに足りない』,ささいな(trivial) / 《名詞の前にのみ用いて》(仕事・活動などが)『小規模の』,ささやかな / 心が狭い,利己的な / (音・声が)弱い,小さい / (文字が)小型の,小文字の / 《the~》小さいもの;(…の)細い部分《+『of』+『名』》 / 《複数形で》《英》(衣類・ハンカチなどの)小物,小間物 / 小さく,細かく / (声などが)低く,弱く / 小規模に,こぢんまりと
(病気が)長期にわたる,慢性の / 《名詞の前にのみ用いて》常習の,癖になった
白血病

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1. 慢性リンパ性白血病に対する治療の概要 overview of the treatment of chronic lymphocytic leukemia
2. 小リンパ球性リンパ腫の臨床症状、病理学的特徴、および診断 clinical manifestations pathologic features and diagnosis of small lymphocytic lymphoma
3. 症候性または進行した慢性リンパ性白血病に対する初期治療の選択 selection of initial therapy for symptomatic or advanced chronic lymphocytic leukemia
4. 慢性リンパ性白血病の臨床症状、病理学的特徴、診断、および鑑別診断 clinical presentation pathologic features diagnosis and differential diagnosis of chronic lymphocytic leukemia
5. 慢性リンパ球性白血病／小リンパ球性リンパ腫におけるリヒタートランスフォーメーションの病理学および治療 pathobiology and treatment of richters transformation in chronic lymphocytic leukemia small lymphocytic lymphoma

Wall S1, Woyach JA2.
Clinics in geriatric medicine.Clin Geriatr Med.2016 Feb;32(1):175-89. doi: 10.1016/j.cger.2015.08.006.
Chronic lymphocytic leukemia affects less than 1% of US adults but is the most common leukemia and primarily affects older patients. Non-Hodgkin lymphomas are the seventh most common cancers in the United States and also primarily affect older patients. In general, older patients should be treated d
PMID 26614867

Lee CS1, Rattu MA2, Kim SS2.
Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners.J Oncol Pharm Pract.2016 Feb;22(1):92-104. doi: 10.1177/1078155214561281. Epub 2014 Nov 25.
Ibrutinib, a Bruton's kinase inhibitor, was granted an accelerated approval by the US Food and Drug Administration in November, 2013, for the treatment of relapsed or refractory mantle cell lymphoma and subsequently for the treatment of relapsed refractory chronic lymphocytic leukemia in February, 2
PMID 25425007

Phosphatidylinositol-3,4-Bisphosphate and Its Binding Protein Lamellipodin Regulate Chemotaxis of Malignant B Lymphocytes.

Li H1, Wu X1, Hou S1, Malek M2, Kielkowska A2, Noh E1, Makondo KJ1, Du Q3, Wilkins JA4, Johnston JB5, Gibson SB6, Lin F7, Marshall AJ8.
Journal of immunology (Baltimore, Md. : 1950).J Immunol.2016 Jan 15;196(2):586-95. doi: 10.4049/jimmunol.1500630. Epub 2015 Dec 22.
Cell migration is controlled by PI3Ks, which generate lipid messengers phosphatidylinositol-3,4,5-trisphosphate and phosphatidylinositol-3,4-bisphosphate [PI(3,4)P2] and consequently recruit pleckstrin homology (PH) domain-containing signaling proteins. PI3K inhibition impairs migration of normal an
PMID 26695371

Iwatani Kayoko,Takata Katsuyoshi,Sato Yasuharu,Miyata-Takata Tomoko,Iwaki Noriko,Cui Wei,Sawada-Kitamura Seiko,Sonobe Hiroshi,Tamura Maiko,Saito Katsuhiko,Miyatani Katsuya,Yamasaki Rie,Yamadori Ichiro,Fujii Nobuharu,Terasaki Yasushi,Maeda Yoshinobu,Tanimoto Mitsune,Nakamura Naoya,Yoshino Tadashi
Human Pathology 45(7), 1379-1387, 2014-07
… Cases of low-grade B-cell lymphoma presenting primarily in the bone marrow are rare, and its clinicopathology remains unclear. … We retrospectively examined patients with low-grade B-cell lymphoma presenting primarily in the bone marrow. …
NAID 120005473076

Cyclin D2 is overexpressed in proliferation centers of chronic lymphocytic leukemia/small lymphocytic lymphoma

IGAWA Takuro,SATO Yasuharu,TAKATA Katsuyoshi,FUSHIMI Soichiro,TAMURA Maiko,NAKAMURA Naoya,MAEDA Yoshinobu,ORITA Yorihisa,TANIMOTO Mitsune,YOSHINO Tadashi
Cancer science 102(11), 2103-2107, 2011-11-10
NAID 10030245494