candida esophagitis

WordNet

1. informal or natural; especially caught off guard or unprepared; "a candid photograph"; "a candid interview"
2. openly straightforward and direct without reserve or secretiveness; "his candid eyes"; "an open and trusting nature"; "a heart-to-heart talk" (同)open, heart-to-heart
3. inflammation of the esophagus; often caused by gastroesophageal reflux (同)oesophagitis
4. any of the yeastlike imperfect fungi of the genus Candida

PrepTutorEJDIC

1. 率直な,腹蔵ない,遠慮のない;(人に)率直な《+『with』+『名』》 / 《名詞の前にのみ用いて》(写真が)相手が意識いないときにとった,ポーズをとらない

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/03/27 14:43:46」(JST)

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Esophageal candidiasis
Classification and external resources
Endoscopic image of esophageal candidiasis in a patient after chemotherapy. Brushings confirmed the presence of hyphae
ICD-9	112.84

Esophageal candidiasis is an opportunistic infection of the esophagus by Candida albicans. The disease usually occurs in patients in immunocompromised states, including post-chemotherapy and in AIDS. However, it can also occur in patients with no predisposing risk factors, and is more likely to be asymptomatic in those patients. It is also known as candidal esophagitis or monilial esophagitis.

Clinical presentation

Patients with esophageal candidiasis present with odynophagia, or painful swallowing. Longstanding esophageal candidiasis can result in weight loss. There is often concomittant thrush.

Some patients present with esophageal candidiasis as a first presentation of systemic candidiasis.

Diagnosis

In most cases the diagnosis is established based on response to therapy. Patients in whom esophageal candidiasis is suspected should receive a brief course of antifungal therapy with fluconazole. If the infection resolves after treatment with fluconazole, then the diagnosis of esophageal candidiasis is made and no further investigation is needed. However, if the infection persists or if there are other factors involved which may warrant further investigation, then patient will undergo an esophagogastroduodenoscopy if it is safe to do so. Endoscopy often reveals classic diffuse raised plaques that characteristically can be removed from the mucosa by the endsocope. Brushing or biopsy of the plaques shows yeast and pseudohyphae by histology that are characteristic of Candida species.

• A severe case of candidiasis

• H&E stain of esophagus showing Candida hyphae within the lamina propria

Therapy

The current first-line treatment is fluconazole, 200 mg. on the first day, followed by daily dosing of 100 mg. for at least 21 days total. Treatment should continue for 14 days after relief of symptoms. [Note: this page previously listed first-line treatment using a single dose of fluconazole (750 mg), but that is actually treatment for oropharyngeal, not esophageal Candidiasis.] Other therapy options include:

• nystatin
• other oral triazoles, such as itraconazole
• caspofungin, used in refractory or systemic cases
• amphotericin, used in refractory or systemic cases

References

UpToDate Contents

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• 1. 口腔咽頭および食道カンジダ症の治療 treatment of oropharyngeal and esophageal candidiasis
• 2. 口腔咽頭および食道カンジダ症の臨床症状 clinical manifestations of oropharyngeal and esophageal candidiasis
• 3. 小児HIV感染の自然経過および分類 natural history and classification of pediatric hiv infection
• 4. カンジダ感染症の概要 overview of candida infections
• 5. 小児におけるカンジダ感染症：概要 candida infections in children an overview

English Journal

• Whipple's disease concomitant with candida esophagitis and subsequent Giardia lamblia coinfection.

• Sulis G1, Villanacci V, Missale G, Salemme M, Castelli F, Caligaris S.
• European journal of gastroenterology & hepatology.Eur J Gastroenterol Hepatol.2014 Oct;26(10):1181-5. doi: 10.1097/MEG.0000000000000154.
• Whipple's disease is a rare systemic condition resulting from a chronic infection by Tropheryma whipplei. Clinical presentation can be widely heterogeneous, often leading to delayed diagnosis and treatment. Furthermore, little is known about the underlying pathogenic mechanisms, although several abn
• PMID 25014626

• Is it possible to diagnose infectious oesophagitis without seeing the causative organism? A histopathological study.

• Demir D1, Doğanavşargil B, Sarsık B, Sezak M, Tunçyürek M.
• The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology.Turk J Gastroenterol.2014 Oct;25(5):481-7. doi: 10.5152/tjg.2014.4967.
• BACKGROUND/AIMS: We investigated the utility of using histological changes to diagnose infectious oesophagitis when causative organisms cannot be seen.MATERIALS AND METHODS: Sixty-seven endoscopic biopsy specimens (51 Candida, 9 herpes simplex virus, 4 tuberculosis, and 3 cytomegalovirus oesophagiti
• PMID 25417607

Japanese Journal

• Candida Esophagitis Complicated by an Esophago-Airway Fistula : Report of a Case

• KANZAKI RYU,YANO MASAHIKO,TAKACHI KO,ISHIGURO SHINGO,MOTOORI MASAAKI,KISHI KENTARO,MIYASHIRO ISAO,ISHIKAWA OSAMU,IMAOKA SHINGI
• Surgery today : the Japanese journal of surgery 39(11), 972-978, 2009-11-01
• NAID 10025555659

• Caspofungin resistance in Candida albicans : correlating clinical outcome with laboratory susceptibility testing of three isogenic isolates serially obtained from a patient with progressive Candida esophagitis

• HERNANDEZ S.
• Antimicrob. Agents Chemother. 48, 1382-1383, 2004
• NAID 30020632102

Related Links

• マルチメディア: Candida Esophagitis: メルクマニュアル18版 ...

Candida Esophagitis Diffuse whitish plaques are typical of Candida esophagitis. Image provided by David M. Martin, MD.

• Candida Esophagitis - TheBody.com

... is Candida esophagitis, (a yeast infection in the esophagus). It is closely related to thrush (a yeast infection in the throat) and Candida vaginitis (a yeast infection in the vagina) and the only difference is it's location in the ...

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関連記事

「Candida」

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　　[★] カンジダ属、カンジダ、Candida属

関

Candida utilis、candidal、Monilia、Torulopsis utilis