oesophagitis

食道炎

関

esophagitis

WordNet

1. inflammation of the esophagus; often caused by gastroesophageal reflux (同)oesophagitis

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/01/06 22:18:36」(JST)

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Esophagitis
Micrograph of herpes esophagitis. H&E stain.
Classification and external resources
Specialty	gastroenterology
ICD-10	K20
ICD-9-CM	530.10
DiseasesDB	9182
MedlinePlus	001153
MeSH	D004941

Esophagitis (or oesophagitis) is inflammation of the esophagus. It may be acute or chronic. Acute esophagitis can be catarrhal or phlegmonous, whereas chronic esophagitis may be hypertrophic or atrophic.

Symptoms

• Heartburn (pain in chest/abdomen, which may radiate to neck/jaw)
• Nausea
• Postprandial worsening of symptoms

Symptoms may be relieved by antacids. Esophagitis causes symptoms of abdominal pain and vomiting. If not treated, it causes discomfort and scarring of the esophagus. This makes swallowing food more difficult.

Causes

Infectious

Forms of infectious esophagitis are typically seen in immunocompromised people. Types include:

• Fungal
  • Candida (Esophageal candidiasis)
• Viral
  • Herpes simplex (Herpes esophagitis)
  • Cytomegalovirus

Endoscopy can be used to distinguish among these conditions.

Other

• The most common cause is gastroesophageal reflux disease (GERD, or GORD in Standard English). If caused by GERD, the disease is also called reflux esophagitis.
• Chemical injury by alkaline or acid solutions may also cause esophagitis, and is usually seen in children, or in adults who attempt suicide by ingestion of caustic substances.
• Physical injury resulting from radiation therapy or by nasogastric tubes may also be responsible.
• Pill esophagitis
• Hyperacidity
• Alcohol abuse
• Eosinophilic esophagitis is a poorly understood form of esophagitis, which is thought to be related to food allergies.
• Crohn's disease – a type of IBD which is also an autoimmune disease where the immune system inflames the gastrointestinal tract – can cause esophagitis if it attacks the esophagus.
• Certain medications, including doxycycline may cause esophagitis if taken incorrectly.

Grading of severity

The severity of esophagitis is commonly classified into four grades according to the Los Angeles Classification:

Grade A	One or more mucosal breaks < 5 mm in maximal length
Grade B	One or more mucosal breaks > 5mm, but without continuity across mucosal folds
Grade C	Mucosal breaks continuous between > 2 mucosal folds, but involving less than 75% of the esophageal circumference
Grade D	Mucosal breaks involving more than 75% of esophageal circumference

References

UpToDate Contents

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• 1. 薬剤誘導性食道炎 medication induced esophagitis
• 2. 好酸球性食道炎の臨床症状および診断 clinical manifestations and diagnosis of eosinophilic esophagitis
• 3. 成人における胃食道逆流症の内科的マネージメント medical management of gastroesophageal reflux disease in adults
• 4. 成人における嚥下障害の概要 overview of dysphagia in adults
• 5. 好酸球性食道炎の治療 treatment of eosinophilic esophagitis

English Journal

• Helicobacter pylori Infection - A Boon or a Bane: Lessons from Studies in a Low-Prevalence Population.

• Lee YY, Mahendra Raj S, Graham DY.SourceDepartment of Medicine, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.
• Helicobacter.Helicobacter.2013 Oct;18(5):338-46. doi: 10.1111/hel.12058. Epub 2013 Apr 22.
• Helicobacter pylori (H. pylori) infection is etiologically associated with gastric cancer and peptic ulcer diseases which are both important public health burdens which could be largely eliminated by H. pylori eradication. However, some investigators urge caution based on the hypothesis that eradi
• PMID 23607896

• Case Report: Helicobacter suis Infection in a Pig Veterinarian.

• Joosten M, Flahou B, Meyns T, Smet A, Arts J, De Cooman L, Pasmans F, Ducatelle R, Haesebrouck F.SourceDepartment of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
• Helicobacter.Helicobacter.2013 Oct;18(5):392-6. doi: 10.1111/hel.12054. Epub 2013 Apr 3.
• This study describes a non-Helicobacter (H.) pylori Helicobacter (NHPH) infection in a pig veterinarian. The patient suffered from reflux esophagitis and general dyspeptic symptoms and was referred to the hospital for upper gastrointestinal endoscopy. Histologic examination of corpus and antrum biop
• PMID 23551953

• In vivo evaluation of acid-induced changes in oesophageal mucosa integrity and sensitivity in non-erosive reflux disease.

• Woodland P, Al-Zinaty M, Yazaki E, Sifrim D.SourceNeurogastroenterology Group, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, UK.
• Gut.Gut.2013 Sep;62(9):1256-61. doi: 10.1136/gutjnl-2012-302645. Epub 2012 Jun 21.
• OBJECTIVE: Patients with non-erosive reflux disease (NERD) have impaired oesophageal mucosal integrity (dilated intercellular spaces). Oesophageal mucosal integrity reflects the balance between repeated reflux damage and mucosal recovery. The relationship between mucosal integrity and acid sensitivi
• PMID 22722617

Japanese Journal

• 好塩基球と好酸球性食道炎・喘息 (AYUMI 好塩基球の光と影 : 体を守るジキル的側面と病気を引き起こすハイド的側面)

• 久保 允人
• 医学のあゆみ 250(12), 1103-1107, 2014-09-20
• NAID 40020196289

• Effect of an Herbal Preparation, STW 5, in an Acute Model of Reflux Oesophagitis in Rats

• ABDEL-AZIZ Heba,ZAKI Hala F.,NEUHUBER Winfried,KELBER Olaf,WEISER Dieter,KHAYYAL Mohamed T.
• Journal of pharmacological sciences 113(2), 134-142, 2010-06-20
• NAID 10027745429

• Effect of an Herbal Preparation, STW 5, in an Acute Model of Reflux Oesophagitis in Rats

• Abdel-Aziz Heba,Zaki Hala F.,Neuhuber Winfried [他],Kelber Olaf,Weiser Dieter,Khayyal Mohamed T.
• Journal of Pharmacological Sciences 113(2), 134-142, 2010
• … We performed this study to test this compound in an acute model of reflux oesophagitis in rats. … Oesophagitis was induced surgically by ligating the pyloric end and fore-stomach. … STW 5 was given orally for 5 days before induction of oesophagitis. … STW 5 proved to be effective in protecting against inflammatory lesions in this model of oesophagitis, thus warranting further investigation of its potential therapeutic usefulness in GERD. …
• NAID 130000251912

Related Links

• Esophagitis - Wikipedia, the free encyclopedia

Esophagitis (or oesophagitis) is inflammation of the esophagus. It may be acute or chronic. The acute esophagitis can be catarrhal or phlegmonous, whereas the chronic esophagitis may be hypertrophic or atrophic.

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