カルシウムチャネル刺激薬、カルシウムチャネル開口薬、カルシウムチャネル作用薬

WordNet

direct the flow of; "channel information towards a broad audience" (同)canalize, canalise
a television station and its programs; "a satellite TV channel"; "surfing through the channels"; "they offer more than one hundred channels" (同)television channel, TV channel
a passage for water (or other fluids) to flow through; "the fields were crossed with irrigation channels"; "gutters carried off the rainwater into a series of channels under the street"
(often plural) a means of communication or access; "it must go through official channels"; "lines of communication were set up between the two firms" (同)communication channel, line
a path over which electrical signals can pass; "a channel is typically what you rent from a telephone company" (同)transmission channel
a deep and relatively narrow body of water (as in a river or a harbor or a strait linking two larger bodies) that allows the best passage for vessels; "the ship went aground in the channel"
(biochemistry) a drug that can combine with a receptor on a cell to produce a physiological reaction
a muscle that contracts while another relaxes; "when bending the elbow the biceps are the agonist"
someone involved in a contest or battle (as in an agon)
a white metallic element that burns with a brilliant light; the fifth most abundant element in the earths crust; an important component of most plants and animals (同)Ca, atomic number 20
official routes of communication; "you have to go through channels"

PrepTutorEJDIC

〈C〉『水路』(川・湾・運河の船の通行ができる深い部分) / 〈U〉河床・川底 / 〈C〉『海峡』 / 〈C〉みぞ(groove),(道路の)水渠(すいきょ) / 《複数形で》(運搬・伝達の)正式の経路(手続き);(一般に)経路 / 〈C〉(テレビ・ラジオの)チャンネル / …‘に'水路を開く / …‘に'みぞを堀る / …'を'伝える,流す
『カルシウム』(金属元素;化学記号は『Ca』)

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/01/02 15:38:45」(JST)

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[Wiki en表示]

A calcium channel opener is a type of drug which facilitates ion transmission through calcium channels.

An example is Bay K8644, which is an analogue of nifedipine that specifically and directly activates L-type voltage-dependent calcium channels.^[1]

In contrast to Bay K8644, which is not for clinical use, Ambroxol is a frequently used mucolytic drug that triggers lysosomal secretion by mobilizing calcium from acidic calcium stores.^[2] This effect does most likely not occur by a direct interaction between the drug and a lysosomal calcium channel, but indirectly by neutralizing the acidic pH within lysosomes. Calcium permeable ion channels in lysosomal membranes that may be activated by a luminal pH increase include two pore channels (TPCs), mucolipin TRP channels (TRPMLs) and purinergic receptors of the P2X channel type.^[3]^[4]

References

^ Schramm M, Thomas G, Towart R, Franckowiak G (1983). "Activation of calcium channels by novel 1,4-dihydropyridines. A new mechanism for positive inotropics or smooth muscle stimulants". Arzneimittelforschung 33 (9): 1268–72. PMID 6196037.
^ Fois, Giorgio; Hobi, Nina; Felder, Edward; Ziegler, Andreas; Miklavc, Pika; Walther, Paul; Radermacher, Peter; Haller, Thomas; Dietl, Paul. "A new role for an old drug: Ambroxol triggers lysosomal exocytosis via pH-dependent Ca2+ release from acidic Ca2+ stores". Cell Calcium 58 (6): 628–637. doi:10.1016/j.ceca.2015.10.002.
^ Patel, Sandip; Cai, Xinjiang. "Evolution of acidic Ca2+ stores and their resident Ca2+-permeable channels". Cell Calcium 57 (3): 222–230. doi:10.1016/j.ceca.2014.12.005.
^ Xu, Haoxing; Ren, Dejian (2015-01-01). "Lysosomal Physiology". Annual Review of Physiology 77 (1): 57–80. doi:10.1146/annurev-physiol-021014-071649. PMC 4524569. PMID 25668017.

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UpToDate Contents

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1. カルシウム拮抗剤の主な副作用および安全性 major side effects and safety of calcium channel blockers
2. 安定狭心症のマネージメントにおけるカルシウム拮抗剤 calcium channel blockers in the management of stable angina pectoris
3. カルシウム拮抗剤中毒 calcium channel blocker poisoning
4. 収縮能障害による心不全の治療の概要 overview of the therapy of heart failure due to systolic dysfunction
5. 切迫早産の予防 inhibition of acute preterm labor

English Journal

Osteoblastic differentiation enhances expression of TRPV4 that is required for calcium oscillation induced by mechanical force.

Suzuki T, Notomi T, Miyajima D, Mizoguchi F, Hayata T, Nakamoto T, Hanyu R, Kamolratanakul P, Mizuno A, Suzuki M, Ezura Y, Izumi Y, Noda M.SourceDepartment of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, Japan; Global Center of Excellence (GCOE) Program, Tokyo Medical and Dental University, Japan; Department of Periodontology, Tokyo Medical and Dental University, Japan.
Bone.Bone.2013 May;54(1):172-8. doi: 10.1016/j.bone.2013.01.001. Epub 2013 Jan 11.
Mechanical stress is known to alter bone mass and the loss of force stimuli leads to reduction of bone mass. However, molecules involved in this phenomenon are incompletely understood. As mechanical force would affect signaling events in cells, we focused on a calcium channel, TRPV4 regarding its ro
PMID 23314072

Metabolic and toxicological considerations for the latest drugs used to treat irritable bowel syndrome.

Mozaffari S, Nikfar S, Abdollahi M.SourceDepartment of Toxicology and Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences , Tehran 1417614411 , Iran Mohammad.Abdollahi@UToronto.Ca ; Mohammad@TUMS.Ac.Ir.
Expert opinion on drug metabolism & toxicology.Expert Opin Drug Metab Toxicol.2013 Apr;9(4):403-21. doi: 10.1517/17425255.2013.759558. Epub 2013 Jan 19.
Introduction: The high prevalence of irritable bowel syndrome (IBS), a chronic gastrointestinal (GI) disorder, its lack of satisfactory effective drugs and its complicated pathophysiology lead to the demand of new therapeutic agents. During a new drug development process, the pharmacokinetic profili
PMID 23330973

Japanese Journal

Goshajinkigan, a Traditional Japanese Medicine, Prevents Oxaliplatin-Induced Acute Peripheral Neuropathy by Suppressing Functional Alteration of TRP Channels in Rat

, , , , , , ,
Journal of Pharmacological Sciences 125(1), 91-98, 2014
… Administration of oxaliplatin increased withdrawal responses from cold stimulation, and GJG or calcium gluconate/magnesium sulfate significantly inhibited the oxaliplatin-induced cold hypersensitivity. …
NAID 130004933173

Pharmacological Evidence Showing Significant Roles for Potassium Channels and CYP Epoxygenase Metabolites in the Relaxant Effects of Docosahexaenoic Acid on the Rat Aorta Contracted with U46619

, , [他], , , , ,
Biological and Pharmaceutical Bulletin 37(3), 394-403, 2014
… In endothelium-denuded rat thoracic aorta, DHA (10−5 <span style="font-variant: small-caps;">M</span>) almost completely relaxed U46619 (a thromboxane A2 (TP) receptor agonist)-contracted muscle without substantially affecting noradrenaline (NA)-induced contraction. …
NAID 130003382129

プロスタグランジン F2α 誘発子宮平滑筋収縮に対する乳清ミネラルの抑制作用およびその抑制機序について

最上おりえ,内田勝幸
ミルクサイエンス 61(2), 81-87, 2012
乳清ミネラル(アラミン996)は乳清に含まれているミネラルであり,これまで月経困難症に有用であることが報告されている。しかし,その機序については明らかではない。そこで,ラット子宮平滑筋のプロスタグランジンF2αによる収縮に対するアラミン996の作用について検討した。プロスタグランジンF2αによる収縮反応の頻度はアラミン996の添加により濃度依存的に抑制された。しかし,収縮力については有意な影響を受 …
NAID 130003398717

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リンク元	「カルシウムチャネル作用薬」「カルシウムチャネル刺激薬」「カルシウムチャネル開口薬」
関連記事	「channel」「calcium」「calcium channel」