English Journal

Mixed chimerism and graft loss in pediatric recipients of an alemtuzumab-based reduced-intensity conditioning regimen for non-malignant disease.

Oshrine BR1, Olson TS, Bunin N.
Pediatric blood & cancer.Pediatr Blood Cancer.2014 Oct;61(10):1852-9. doi: 10.1002/pbc.25113. Epub 2014 Jun 17.
BACKGROUND: Reduced-intensity conditioning (RIC) regimens can mitigate the toxicity of hematopoietic cell transplantation (HCT) in children with non-malignant diseases, but are associated with increased risk for post-transplant mixed donor/recipient chimerism (MC) and/or graft loss (GL). Interventio
PMID 24939325

Establishment of Transplantation Tolerance via Minimal Conditioning in Aged Recipients.

Morison JK1, Homann J, Hammett MV, Lister N, Layton D, Malin MA, Thorburn AN, Chidgey AP, Boyd RL, Heng TS.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.Am J Transplant.2014 Sep 12. doi: 10.1111/ajt.12929. [Epub ahead of print]
Mixed hematopoietic chimerism is a powerful means of generating donor-specific tolerance, allowing long-term graft acceptance without lifelong dependence on immunosuppressive drugs. To avoid the need for whole body irradiation and associated side effects, we utilized a radiation-free minimal conditi
PMID 25220786

Xenotransplantation assessment: morphometric study of human spermatogonial stem cells in recipient mouse testes.

Mirzapour T1, Movahedin M, Koruji M, Nowroozi MR.
Andrologia.Andrologia.2014 Sep 11. doi: 10.1111/and.12310. [Epub ahead of print]
The purpose of this study was (i) To establish in vitro propagation of human spermatogonial stem cells (hSSCs) from small testicular biopsies to obtain a high number of cells; (ii) to evaluate the presence of functional hSSCs in culture system by RT-PCR using DAZL, α6-Integrin, β1-Integrin genes;
PMID 25209022