biosynthesis of cholesterol

コレステロールの生合成

WordNet

1. an animal sterol that is normally synthesized by the liver; the most abundant steroid in animal tissues (同)cholesterin
2. production of a chemical compound by a living organism (同)biogenesis

PrepTutorEJDIC

1. 《所有・所属》…『の』,…のものである,…に属する・《材料・要素》…『でできた』,から成る・《部分》…『の』[『中の』] ・《数量・単位・種類を表す名詞に付いて》…の・《原因・動機》…『で』,のために(because of) ・《主格関係》…『の』,による,によって・《目的格関係》…『を』,の・《同格関係》…『という』・《関係・関連》…『についての』[『の』],の点で・《抽象名詞などと共に》…の[性質をもつ] ・《『It is』+『形』+『of』+『名』+『to』 doの形で,ofの後の名詞を意味上の主語として》・《分離》…『から』・《起原・出所》…『から』[『の』](out of) ・《『名』+『of』+『a』(『an』)+『名』の形で》…のような・《『名』+『of』+『mine』(『yours, his』など独立所有格)の形で》…の…・《時》(1)《副詞句を作って》…に《形容詞句を作って》…の・《時刻》《米》…前(to,《米》before)
2. コレステロール(胆汁・血液・神経組織などの脂肪性成分)
3. OLD French古[代]フランス語

UpToDate Contents

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• 1. 副腎ステロイド生合成 adrenal steroid biosynthesis
• 2. 二次予防における脂質（高コレステロール血症を含む）の治療 treatment of lipids including hypercholesterolemia in secondary prevention
• 3. 冠動脈疾患または同等の冠動脈リスクを有する患者におけるコレステロール低下に関する
  臨床試験 clinical trials of cholesterol lowering in patients with coronary heart disease or coronary risk equivalents
• 4. スタチン：作用、副作用、および投与 statins actions side effects and administration
• 5. 高コレステロール血症の治療のためのATP IIIガイドライン atp iii guidelines for treatment of high blood cholesterol

English Journal

• Mitochondria-associated ER membranes in Alzheimer disease.

• Schon EA, Area-Gomez E.SourceDepartment of Neurology, Columbia University, New York, NY, USA; Department of Genetics and Development, Columbia University, New York, NY, USA.
• Molecular and cellular neurosciences.Mol Cell Neurosci.2013 Jul;55:26-36. doi: 10.1016/j.mcn.2012.07.011. Epub 2012 Aug 24.
• Alzheimer disease (AD) is associated with the accumulation in the brain of extracellular neuritic plaques composed mainly of β-amyloid (Aβ) and of intracellular neurofibrillary tangles composed of hyperphosphorylated forms of the microtubule-associated protein tau. It is also associated with other
• PMID 22922446

• Effects of naphthenic acid exposure on development and liver metabolic processes in anuran tadpoles.

• Melvin SD, Lanctôt CM, Craig PM, Moon TW, Peru KM, Headley JV, Trudeau VL.SourceCentre for Advanced Research in Environmental Genomics, Department of Biology, University of Ottawa, Ottawa, Ontario K1N 6N5, Canada. Electronic address: smelvin18@gmail.com.
• Environmental pollution (Barking, Essex : 1987).Environ Pollut.2013 Jun;177:22-7. doi: 10.1016/j.envpol.2013.02.003. Epub 2013 Mar 1.
• Naphthenic acids (NA) are used in a variety of commercial and industrial applications, and are primary toxic components of oil sands wastewater. We investigated developmental and metabolic responses of tadpoles exposed to sub-lethal concentrations of a commercial NA blend throughout development. We
• PMID 23466728

Japanese Journal

• Mechanism of Statin-Induced Rhabdomyolysis

• Sakamoto Kazuho,Kimura Junko
• Journal of
• … Statins, a group of drugs used for the treatment of hypercholesterolemia, have adverse effects on skeletal muscle. … The symptoms of these effects range from slight myalgia to severe rhabdomyolysis. … The number of patients currently taking statins is estimated to be several millions worldwide. … However, the mechanism of statins' myotoxic effects is unclear. …
• NAID 130003382619

• 選択的固相抽出法を用いるイソペンテニルピロリン酸とジメチルアリルピロリン酸との合量のLC/MS/MS定量

• 佐藤 友美,桑原 直子,中川 沙織,大和 進
• 分析化学 62(8), 731-735, 2013
• … Isoprenoids are intermediates of cholesterol biosynthesis, and are also related to Ras prenylation associated with cell proliferations. … Recently, an inhibitory effect of bisphosphonate on the biosynthesis of isoprenoids has been noted as a target of an anti-cancer drug. … There were small amounts of isporenoids in the biological fluid; …
• NAID 130003362088

• Comparison of Constitutive Gene Expression Levels of Hepatic Cholesterol Biosynthetic Enzymes between Wistar-Kyoto and Stroke-Prone Spontaneously Hypertensive Rats

• Nemoto Kiyomitsu,Ikeda Ayaka,Ito Sei [他],Miyata Misaki,Yoshida Chiaki,Degawa Masakuni
• Biological and Pharmaceutical Bulletin 36(7), 1216-1220, 2013
• … Serum total cholesterol amounts in the stroke-prone hypertensive rat (SHRSP) strain are lower than in the normotensive control strain, Wistar-Kyoto (WKY) rat. … To understand the strain difference, constitutive gene expression levels of hepatic cholesterol biosynthetic enzymes in male 8-week-old SHRSP and WKY rats were comparatively examined by DNA microarray and real-time reverse transcription-polymerase chain reaction (RT-PCR) analyses. …
• NAID 130003361482

Related Links

• Cholesterol: Synthesis, Metabolism, Regulation

The cholesterol page discusses the biosynthesis and functions of cholesterol and therapeutic means to intervene in hypercholesterolemia. ... Acetyl-CoA units are converted to mevalonate by a series of reactions that begins with the ...

• Cholesterol Synthesis and the Cholesterol Biosynthesis Pathway

This flow chart shows how the synthesis of cholesterol occurs in the body, as well as how statins interfere with the synthesis of important nutrients like CoQ10 and squalene. ... Cholesterol Synthesis and the Cholesterol Biosynthesis ...

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★リンクテーブル★

リンク元	「コレステロール生合成」
関連記事	「biosynthesis」「cholesterol」

「コレステロール生合成」

　　[★]

英

cholesterol biosynthesis, biosynthesis of cholesterol

関

コレステロール

• コレステロールは酢酸を原料として合成される。

acetyl-CoA→hydroxymethyl-glutaryl coenzyme A(HMG-CoA)－(HMG-CoA reductase)→mebaronate→･･･→コレステロール

「biosynthesis」

　　[★]

• 生合成

関

biogenesis、biogenetic、biosyntheses、biosynthetic

　

「cholesterol」

　　[★] コレステロール