binding constant

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関

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Km

WordNet

1. executed with proper legal authority; "a binding contract"
2. the protective covering on the front, back, and spine of a book; "the book had a leather binding" (同)book binding, cover, back
3. strip sewn over or along an edge for reinforcement or decoration
4. the capacity to attract and hold something
5. steadfast in purpose or devotion or affection; "a man constant in adherence to his ideals"; "a constant lover"; "constant as the northern star"
6. a number representing a quantity assumed to have a fixed value in a specified mathematical context; "the velocity of light is a constant"
7. a quantity that does not vary (同)constant quantity, invariable

PrepTutorEJDIC

1. 義務的な,拘束力ある / 〈U〉しばること;〈C〉しばる物 / 〈C〉製本,装丁 / 〈U〉縁(‘ふち')取り材料
2. 『不変の』,一定の / 『絶え間のない』,不断の,繰り返される / 《文》〈人が〉心変わりしない;(…に対して)誠実な,貞節な《+『to』+『名』》 / (数学で)常数;(化学・物理分析などにおける)定量

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/06/09 22:35:06」(JST)

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The binding constant is a special case of the equilibrium constant . It is associated with the binding and unbinding reaction of receptor (R) and ligand (L) molecules, which is formalized as:

.

The reaction is characterized by the on-rate constant and the off-rate constant , which have units of 1/(concentration time) and 1/time, respectively. In equilibrium, the forward binding transition should be balanced by the backward unbinding transition . That is,

,

where , and represent the concentration of unbound free receptors, the concentration of unbound free ligand and the concentration of receptor-ligand complexes. The binding constant, or the association constant is defined by

.

An often considered quantity is the dissociation constant , which has the unit of concentration, despite the fact that strictly speaking, all association constants are unitless values. The inclusion of units arises from the simplification that such constants are calculated solely from concentrations, which is not the case. Once chemical activity is factored into the correct form of the equation, a dimensionless value is obtained. For the binding of receptor and ligand molecules in solution, the molar Gibbs free energy , or the binding affinity is related to the dissociation constant via

,

in which is the ideal gas constant, temperature and the standard reference concentration = 1 mol / L.

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English Journal

• Thermodynamics of the enantiomers of amino acid and monosaccharide binding to fullerenol used as an artificial sweet taste receptor model.

• Dong WR, Chen G, Chen ZX, Deng SP.SourceFood Sensory Lab, Zhejiang Gongshang University, Hangzhou, Zhejiang 310035, PR China.
• Food chemistry.Food Chem.2013 Dec 1;141(3):3110-7. doi: 10.1016/j.foodchem.2013.05.160. Epub 2013 Jun 11.
• Fullerenol was used as sweet taste receptor model to investigate the binding affinities of structurally related pairs of enantiomers by isothermal titration calorimetry (ITC). It reveals that amino acid binding with fullerenol are enthalpy-cost and entropically-driven processes, whereas enthalpy con
• PMID 23871066

• Complexes between linoleate and native or aggregated β-lactoglobulin: Interaction parameters and in vitro cytotoxic effect.

• Le Maux S, Bouhallab S, Giblin L, Brodkorb A, Croguennec T.SourceINRA, UMR1253 STLO, 65 rue de Saint Brieuc, F-35042 Rennes, France; AGROCAMPUS OUEST, UMR1253 STLO, 65 rue de Saint Brieuc, F-35042 Rennes, France; Teagasc Food Research Centre, Moorepark, Fermoy, Co. Cork, Ireland. Electronic address: Solene.Le.Maux@agrocampus-ouest.fr.
• Food chemistry.Food Chem.2013 Dec 1;141(3):2305-13. doi: 10.1016/j.foodchem.2013.05.031. Epub 2013 May 17.
• The dairy protein β-lactoglobulin (βlg) is known to form a complex with fatty acids (FA). Due to industrial processing, βlg is often in its non-native form in food products, which can modify the FA/βlg complex properties. We investigated the interaction of bovine βlg, in selected structural for
• PMID 23870962

• Activated effect of lignin on α-amylase.

• Zhang J, Cui JH, Yin T, Sun L, Li G.SourceSchool of Life Sciences, Shanghai University, Shanghai 200444, PR China.
• Food chemistry.Food Chem.2013 Dec 1;141(3):2229-37. doi: 10.1016/j.foodchem.2013.05.047. Epub 2013 May 23.
• This paper reports a new kind of activator of α-amylase, lignin, which can greatly increase α-amylase activity. The promoted ratio of lignin is even much higher than that of chloride ion, the traditional activator of α-amylase. Further experimental results reveal that lignin may interact with α-
• PMID 23870952

Japanese Journal

• Determination of dissociation constant of the NF kappa B p50/p65 heterodimer using fluorescence cross-correlation spectroscopy in the living cell

• Tiwari Manisha,Mikuni Shintaro,Muto Hideki,Kinjo Masataka
• Biochemical and Biophysical Research Communications 436(3), 430-435, 2013-07-05
• … These results suggest the different binding affinities of the p50/p65 heterodimer in the cytoplasm and nucleus of the living cell and different complex formation in each region. …
• NAID 120005322431

• A novel lophine-based fluorescence probe and its binding to human serum albumin

• Kishikawa Naoya,Ohyama Kaname,Saiki Akane,Matsuo Aya,Ali Marwa Fathy Bakr,Wada Mitsuhiro,Nakashima Kenichiro,Kuroda Naotaka
• Analytica Chimica Acta 780, 1-6, 2013-05-30
• … The binding of a lophine-based fluorescence probe, 4-[4-(4-dimethylaminophenyl)-5-phenyl-1H-imidazol-2-yl]benzoic acid methyl ester (DAPIM) with human serum albumin (HSA) was investigated by fluorescence spectroscopy under physiological conditions. … While DAPIM shows extreme low fluorescence in aqueous solution, DAPIM binding with HSA emits strong fluorescence at 510nm. …
• NAID 120005303650

• Structure Parameters and Electric Field Effects on Exciton Binding Energies of CdTe/ZnTe Quantum Rings

• Hong Woo-Pyo,Park Seoung-Hwan,Jung Young-Dae
• Jpn J Appl Phys 52(3), 035205-035205-6, 2013-03-25
• … We study the effects of the structural parameters such as the wetting layer thickness and the size of self-assembled CdTe/ZnTe quantum rings (QRs) under an external electric field on the exciton binding energies due to Coulomb interaction between electrons and holes with a finite-element method based on the linear elasticity theory of solids and the eight-band \mathbf{k}\cdot \mathbf{p} Hamiltonian. …
• NAID 150000106563

Related Links

• Binding constant - Wikipedia, the free encyclopedia

The binding constant is a special case of the equilibrium constant K . It is associated with the binding and unbinding reaction of receptor (R) and ligand (L) molecules, which is formalized as: {\rm R} + {\rm L}\rightleftharpoons {\rm . The reaction ...

• Binding and kinetics

[AB]. {M} = {M}{M}. {M}. (Conversely, equilibrium binding constant, KB, is defined as: KB = [AB]. [A][B]. {M 1} = {M}. {M}{M}. ) KD = koff kon. = [A] [B]. [AB] koff: {s-1} kon: {M-1·s-1 }. Rate constants: Where does this KD come from? From Lecture 5: ...

Related Pictures

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★リンクテーブル★

リンク元	「association constant」「coupling constant」
関連記事	「binding」「constant」

「association constant」

　　[★]

• 会合定数、結合定数

関

binding constant、coupling constant

「coupling constant」

　　[★]

結合定数

関

association constant、binding constant

「binding」

　　[★]

• n.

• 結合、バインディング

• adj.

• 結合性の

関

affinity、associate、bind、bond、bonding、combine、conjoin、conjugate、conjugation、conjunction、connect、connection、connective、connectivity、couple、dock、engage、engagement、join、ligate、linkage、symphysial、symphysic、union

　 　 　 　 　

「constant」

　　[★]

• adj.

• 定常性の、一定の、普遍の

• n.

• 定数

関

constancy、constantly、invariable、invariably、stationary、uniform