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Determination of bevantolol in human plasma using liquid chromatography-electrospray ionization tandem mass spectrometry and its application to a bioequivalence study.

Ren L1, Wang Z2, Lou Y2, Zheng L3, Zheng H4, Yin C5.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.J Chromatogr B Analyt Technol Biomed Life Sci.2014 May 15;959:16-21. doi: 10.1016/j.jchromb.2014.03.040. Epub 2014 Apr 13.
A liquid chromatography-electrospray ionization tandem mass spectrometry method was established and validated for the determination of bevantolol in human plasma using propranolol as the internal standard. The optimal chromatographic behavior of bevantolol and propranolol was achieved on a Welch Ult
PMID 24747519

MH-3: evidence for non-competitive antagonism towards the low-affinity site of β1-adrenoceptors.

Schlicker E1, Pędzińska-Betiuk A, Kozłowska H, Szkaradek N, Zelaszczyk D, Baranowska-Kuczko M, Kieć-Kononowicz K, Marona H, Malinowska B.
Naunyn-Schmiedeberg's archives of pharmacology.Naunyn Schmiedebergs Arch Pharmacol.2014 May 3. [Epub ahead of print]
β-Adrenoceptor antagonists are important drugs for the treatment of cardiovascular diseases and some of those drugs also block the so-called low-affinity site of β1-adrenoceptors although at much higher concentrations. This low-affinity site, also identified in vivo and in human tissue, may come i
PMID 24788554

Different changes of plasma membrane beta-adrenoceptors in rat heart after chronic administration of propranolol, atenolol and bevantolol.

Horinouchi T1, Morishima S, Tanaka T, Suzuki F, Tanaka Y, Koike K, Miwa S, Muramatsu I.
Life sciences.Life Sci.2007 Jul 12;81(5):399-404. Epub 2007 Jun 16.
Recently, tissue segment binding method with a hydrophilic radioligand [(3)H]-CGP12177 was developed to detect plasma membrane beta-adrenoceptors in rat heart (Horinouchi et al., 2006). In the present study, propranolol (40 mg kg(-1) day(-1)), atenolol (40 mg kg(-1) day(-1)) and bevantolol (200 mg k
PMID 17628611