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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/09/07 21:40:06」(JST)

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Bevantolol (INN) is a drug that acts as both a beta blocker and a calcium channel blocker.^[1]

References

^ Warltier DC, Gross GJ, Jesmok GJ, Brooks HL, Hardman HF (1980). "Protection of Ischemic Myocardium: Comparison of Effects of Propranolol, Bevantolol and N-Dimethyl Propranolol on Infarct Size Following Coronary Artery Occlusion in Anesthetized Dogs". Cardiology 66.

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English Journal

Carboxymethyl β-cyclodextrin as chiral selector in capillary electrophoresis: enantioseparation of 16 basic chiral drugs and its chiral recognition mechanism associated with drugs' structural features.

Fang L1, Du Y1, Hu X1, Luo L1, Guo X1, Guo X1, Yu J1.
Biomedical chromatography : BMC.Biomed Chromatogr.2017 Apr 21. doi: 10.1002/bmc.3991. [Epub ahead of print]
PMID 28431453

Blood pressure lowering efficacy of beta-1 selective beta blockers for primary hypertension.

Wong GW1, Boyda HN, Wright JM.
The Cochrane database of systematic reviews.Cochrane Database Syst Rev.2016 Mar 10;3:CD007451. doi: 10.1002/14651858.CD007451.pub2.
PMID 26961574

MH-3: evidence for non-competitive antagonism towards the low-affinity site of β1-adrenoceptors.

Schlicker E1, Pędzińska-Betiuk A, Kozłowska H, Szkaradek N, Żelaszczyk D, Baranowska-Kuczko M, Kieć-Kononowicz K, Marona H, Malinowska B.
Naunyn-Schmiedeberg's archives of pharmacology.Naunyn Schmiedebergs Arch Pharmacol.2014 Aug;387(8):743-52. doi: 10.1007/s00210-014-0983-3. Epub 2014 May 3.
PMID 24788554

Japanese Journal

Effect of bevantolol hydrochloride on immobilization stress-induced hypertension and central β-adrenoceptors in rats

TAKITA M
Pharmacol. Biochem. Behav. 45, 623-627, 1993
NAID 80007102241

選択的β_1-受容体遮断薬Bevantolol hydrochloride の一般薬理作用

平手謙二
応用薬理 44, 167-187, 1992
NAID 80006643970

Effect of Bevantolol Hydrochloride, a .BETA.-Blocker, on Hemodynamics in the Resting State and during Exercise Loading in Essential Hypertensives.

斉藤俊弘,岩田次郎,大沼徳吉,山本光之,甲斐教之,山本和利,稲垣義明
臨床薬理 23(4), 679-685, 1992
… Bevantolol hydrochloride is a new β1-selective β-adrenoceptor antagonist without intrinsic sympathomimetic activity. … It has been also reported that bevantolol has α1-blocking activity and calcium antagonistic action. … The effects of bevantolol on hemodynamics in the resting state and during exercise loading were investigated in 7 patients with mild or moderate essential hypertension.The treatment of bevantolol was started from 100mg twice a day. …
NAID 130002045696

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拡張検索	「bevantolol hydrochloride」

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Bevantolol
Systematic (IUPAC) name
	(RS)-[2-(3,4-dimethoxyphenyl)ethyl][2-hydroxy-3-(3-methylphenoxy)propyl]amine
Clinical data
AHFS/Drugs.com	International Drug Names
Legal status	℞ (Prescription only);
Routes of; administration	Oral
Identifiers
CAS Registry Number	59170-23-9
ATC code	C07AB06
PubChem	CID: 2372
DrugBank	DB01295
ChemSpider	2282
UNII	34ZXW6ZV21
ChEBI	CHEBI:238698
ChEMBL	CHEMBL314010
Chemical data
Formula	C20H27NO4
Molecular mass	345.43 g/mol
	SMILES O(c1ccc(cc1OC)CCNCC(O)COc2cc(ccc2)C)C ;
	InChI InChI=1S/C20H27NO4/c1-15-5-4-6-18(11-15)25-14-17(22)13-21-10-9-16-7-8-19(23-2)20(12-16)24-3/h4-8,11-12,17,21-22H,9-10,13-14H2,1-3H3 ; Key:HXLAFSUPPDYFEO-UHFFFAOYSA-N ;
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