- 関
- beta-1 adrenergic receptor、beta1 adrenergic receptor、beta1 adrenoceptor
WordNet
- to remain unmolested, undisturbed, or uninterrupted -- used only in infinitive form; "let her be"
- work in a specific place, with a specific subject, or in a specific function; "He is a herpetologist"; "She is our resident philosopher" (同)follow
- have life, be alive; "Our great leader is no more"; "My grandfather lived until the end of war" (同)live
- be identical to; be someone or something; "The president of the company is John Smith"; "This is my house"
- happen, occur, take place; "I lost my wallet; this was during the visit to my parents house"; "There were two hundred people at his funeral"; "There was a lot of noise in the kitchen"
- have the quality of being; (copula, used with an adjective or a predicate noun); "John is rich"; "This is not a good answer"
- occupy a certain position or area; be somewhere; "Where is my umbrella?" "The toolshed is in the back"; "What is behind this behavior?"
- spend or use time; "I may be an hour"
- stake on the outcome of an issue; "I bet $100 on that new horse"; "She played all her money on the dark horse" (同)wager, play
- the act of gambling; "he did it on a bet" (同)wager
- maintain with or as if with a bet; "I bet she will be there!" (同)wager
- second in order of importance; "the candidate, considered a beta male, was perceived to be unable to lead his party to victory"
- the 2nd letter of the Greek alphabet
- preliminary or testing stage of a software or hardware product; "a beta version"; "beta software"
- beets (同)genus Beta
PrepTutorEJDIC
- 《連結語として補語を伴なって…『である』,…だ,…です / 《位置・場所を表す語句を伴って》(…に)『ある』,いる(occupy a place or situation) / 〈物事が〉『存在する』,ある(exist);〈生物が〉生存する,生きている(live) / 行われる,起こる,発生する(take place, occur) / 存続する,そのままでいる(remain as before) / 《『be to』 do》 / …する予定である,…することになっている / …すべきだ / 《受動態の不定詞を伴って》…できる / 《命令》…するのだ / 《条件節に》…する意図がある / 《『if…were to』 do》…するとしたなら / 《『be』 do『ing』》《進行形》 / 《進行中の動作》…している,しつつある / 《近い未来》…しようとしている,するつもり / 《動作の反復》(いつも)…している / 《『be』+『他動詞の過去分詞』》《受動態》…される,されている / 《『be』+『自動詞の過去分詞』》《完了形》…した[状態にある]
- 『かけ』・(…との)かけ《+『with』+『名』》 / かけた物(金) / かけの対象 / 〈金・物〉'を'『かける』 / (かけ事・ゲームなどで)〈人〉‘と'『かけをする』《+『名』〈人〉+『on』+『名』》 / (…に)『かける』《+『on』(『against』)+『名』(one's do『ing』)》
- ベータ(ギリシア語アルファベットの第2文字;B,β;英語のB,b に遭当)
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/07/19 11:55:22」(JST)
[Wiki en表示]
ADRB1 |
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Available structures |
PDB |
Ortholog search: PDBe RCSB |
List of PDB id codes |
2LSQ
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Identifiers |
Aliases |
ADRB1, ADRB1R, B1AR, BETA1AR, RHR, adrenoceptor beta 1 |
External IDs |
OMIM: 109630 MGI: 87937 HomoloGene: 20171 GeneCards: 153 |
Gene ontology |
Molecular function |
• beta-adrenergic receptor activity
• PDZ domain binding
• receptor signaling protein activity
• G-protein coupled receptor activity
• epinephrine binding
• norepinephrine binding
• signal transducer activity
• adrenergic receptor activity
• protein binding
• alpha-2A adrenergic receptor binding
• protein heterodimerization activity
• Ras guanyl-nucleotide exchange factor activity
• beta1-adrenergic receptor activity
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Cellular component |
• integral component of membrane
• endosome
• membrane
• plasma membrane
• integral component of plasma membrane
• early endosome
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Biological process |
• positive regulation of cAMP biosynthetic process
• G-protein coupled receptor signaling pathway
• fear response
• intracellular signal transduction
• adenylate cyclase-activating G-protein coupled receptor signaling pathway
• negative regulation of multicellular organism growth
• cell-cell signaling
• positive regulation of cAMP-mediated signaling
• positive regulation of heart rate by epinephrine-norepinephrine
• activation of adenylate cyclase activity
• vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure
• diet induced thermogenesis
• adenylate cyclase-activating adrenergic receptor signaling pathway
• positive regulation of heart contraction
• positive regulation of GTPase activity
• positive regulation of the force of heart contraction by epinephrine-norepinephrine
• heat generation
• brown fat cell differentiation
• response to cold
• temperature homeostasis
• signal transduction
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Sources:Amigo / QuickGO |
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RNA expression pattern |
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More reference expression data |
Orthologs |
Species |
Human |
Mouse |
Entrez |
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Ensembl |
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UniProt |
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RefSeq (mRNA) |
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RefSeq (protein) |
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Location (UCSC) |
Chr 10: 114.04 – 114.05 Mb |
Chr 19: 56.72 – 56.72 Mb |
PubMed search |
[1] |
[2] |
Wikidata |
View/Edit Human |
View/Edit Mouse |
The beta-1 adrenergic receptor (β1 adrenoreceptor), also known as ADRB1, is a beta-adrenergic receptor, and also denotes the human gene encoding it.[1] It is a G-protein coupled receptor associated with the Gs heterotrimeric G-protein and is expressed predominantly in cardiac tissue.
Contents
- 1 Receptor
- 1.1 Actions
- 1.2 Agonists
- 1.3 Antagonists
- 1.4 Mechanism
- 2 Gene
- 3 Interactions
- 4 See also
- 5 References
- 6 External links
- 7 Further reading
Receptor
Actions
Actions of the β1 receptor include:
- stimulate viscous, amylase-filled secretions from salivary glands[2]
- Increase cardiac output
- Increase heart rate[3] in sinoatrial node (SA node) (chronotropic effect)
- Increase atrial cardiac muscle contractility. (inotropic effect)
- Increases contractility and automaticity[3] of ventricular cardiac muscle.
- Increases conduction and automaticity[3] of atrioventricular node (AV node)
- Renin release from juxtaglomerular cells.[3]
- Lipolysis in adipose tissue.[3]
- Receptor also present in cerebral cortex.
Agonists
Isoprenaline has higher affinity for β1 than adrenaline, which, in turn, binds with higher affinity than noradrenaline at physiologic concentrations. Selective agonists to the beta-1 receptor are:
- Denopamine
- Dobutamine[2] (in cardiogenic shock)
- Xamoterol[2] (cardiac stimulant)
Antagonists
(Beta blockers) β1-selective ones are:
- Acebutolol (in hypertension, angina pectoris and arrhythmias)
- Atenolol[2] (in hypertension, coronary heart disease, arrhythmias and myocardial infarction)
- Betaxolol (in hypertension and glaucoma)
- Bisoprolol[4] (in hypertension, coronary heart disease, arrhythmias, myocardial infarction and ischemic heart diseases)
- Esmolol (in arrhythmias)
- Metoprolol[2] (in hypertension, coronary heart disease, myocardial infarction and heart failure)
- Nebivolol (in hypertension)
- Vortioxetine (antidepressant)
Mechanism
Gs renders adenylate cyclase activated, resulting in increase of cAMP.
Gene
Specific polymorphisms in the ADRB1 gene have been shown to affect the resting heart rate and can be involved in heart failure.[1]
Interactions
Beta-1 adrenergic receptor has been shown to interact with DLG4[5] and GIPC1.[6] Interaction between testosterone and β-1 ARs have been shown in anxiolytic behaviors in the basolateral amygdala.[7]
See also
- Other adrenergic receptors
- Alpha-1 adrenergic receptor
- Alpha-2 adrenergic receptor
- Beta-2 adrenergic receptor
- Beta-3 adrenergic receptor
References
- ^ a b "Entrez Gene: ADRB1 adrenergic, beta-1-, receptor".
- ^ a b c d e Rang, H. P. (2003). Pharmacology. Edinburgh: Churchill Livingstone. ISBN 0-443-07145-4. Page 163
- ^ a b c d e Fitzpatrick, David; Purves, Dale; Augustine, George (2004). "Table 20:2". Neuroscience (Third ed.). Sunderland, Mass: Sinauer. ISBN 0-87893-725-0.
- ^ American Society of Health-System Pharmacists, Inc. (2005-01-01). "Bisoprolol". MedlinePlus Drug Information. U.S. National Library of Medicine, National Institutes of Health. Archived from the original on 2008-05-20. Retrieved 2008-06-06.
- ^ Hu LA, Tang Y, Miller WE, Cong M, Lau AG, Lefkowitz RJ, Hall RA (Dec 2000). "beta 1-adrenergic receptor association with PSD-95. Inhibition of receptor internalization and facilitation of beta 1-adrenergic receptor interaction with N-methyl-D-aspartate receptors". The Journal of Biological Chemistry 275 (49): 38659–66. doi:10.1074/jbc.M005938200. PMID 10995758.
- ^ Hu LA, Chen W, Martin NP, Whalen EJ, Premont RT, Lefkowitz RJ (Jul 2003). "GIPC interacts with the beta1-adrenergic receptor and regulates beta1-adrenergic receptor-mediated ERK activation". The Journal of Biological Chemistry 278 (28): 26295–301. doi:10.1074/jbc.M212352200. PMID 12724327.
- ^ Mard-Soltani M, Kesmati M, Khajehpour L, Rasekh A, Shamshirgar-Zadeh A (April 2012). "Interaction between Anxiolytic Effects of Testosterone and β-1 Adrenoceptors of Basolateral Amygdala". International Journal of Pharmacology 8 (5): 344–354. doi:10.3923/ijp.2012.344.354.
External links
- "β1-adrenoceptor". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
Further reading
- Frielle T, Kobilka B, Lefkowitz RJ, Caron MG (Jul 1988). "Human beta 1- and beta 2-adrenergic receptors: structurally and functionally related receptors derived from distinct genes". Trends in Neurosciences 11 (7): 321–4. doi:10.1016/0166-2236(88)90095-1. PMID 2465637.
- Muszkat M (Aug 2007). "Interethnic differences in drug response: the contribution of genetic variability in beta adrenergic receptor and cytochrome P4502C9". Clinical Pharmacology and Therapeutics 82 (2): 215–8. doi:10.1038/sj.clpt.6100142. PMID 17329986.
- Yang-Feng TL, Xue FY, Zhong WW, Cotecchia S, Frielle T, Caron MG, Lefkowitz RJ, Francke U (Feb 1990). "Chromosomal organization of adrenergic receptor genes". Proceedings of the National Academy of Sciences of the United States of America 87 (4): 1516–20. doi:10.1073/pnas.87.4.1516. PMC 53506. PMID 2154750.
- Forse RA, Leibel R, Gagner M (Jan 1989). "The effect of Escherichia coli endotoxin on the adrenergic control of lipolysis in the human adipocyte". The Journal of Surgical Research 46 (1): 41–8. doi:10.1016/0022-4804(89)90180-7. PMID 2536864.
- Frielle T, Collins S, Daniel KW, Caron MG, Lefkowitz RJ, Kobilka BK (Nov 1987). "Cloning of the cDNA for the human beta 1-adrenergic receptor". Proceedings of the National Academy of Sciences of the United States of America 84 (22): 7920–4. doi:10.1073/pnas.84.22.7920. PMC 299447. PMID 2825170.
- Stiles GL, Strasser RH, Lavin TN, Jones LR, Caron MG, Lefkowitz RJ (Jul 1983). "The cardiac beta-adrenergic receptor. Structural similarities of beta 1 and beta 2 receptor subtypes demonstrated by photoaffinity labeling". The Journal of Biological Chemistry 258 (13): 8443–9. PMID 6305985.
- Hoehe MR, Otterud B, Hsieh WT, Martinez MM, Stauffer D, Holik J, Berrettini WH, Byerley WF, Gershon ES, Lalouel JM (Jun 1995). "Genetic mapping of adrenergic receptor genes in humans". Journal of Molecular Medicine 73 (6): 299–306. doi:10.1007/BF00231616. PMID 7583452.
- Elies R, Ferrari I, Wallukat G, Lebesgue D, Chiale P, Elizari M, Rosenbaum M, Hoebeke J, Levin MJ (Nov 1996). "Structural and functional analysis of the B cell epitopes recognized by anti-receptor autoantibodies in patients with Chagas' disease". Journal of Immunology 157 (9): 4203–11. PMID 8892658.
- Oldenhof J, Vickery R, Anafi M, Oak J, Ray A, Schoots O, Pawson T, von Zastrow M, Van Tol HH (Nov 1998). "SH3 binding domains in the dopamine D4 receptor". Biochemistry 37 (45): 15726–36. doi:10.1021/bi981634. PMID 9843378.
- Mason DA, Moore JD, Green SA, Liggett SB (Apr 1999). "A gain-of-function polymorphism in a G-protein coupling domain of the human beta1-adrenergic receptor". The Journal of Biological Chemistry 274 (18): 12670–4. doi:10.1074/jbc.274.18.12670. PMID 10212248.
- Moore JD, Mason DA, Green SA, Hsu J, Liggett SB (Sep 1999). "Racial differences in the frequencies of cardiac beta(1)-adrenergic receptor polymorphisms: analysis of c145A>G and c1165G>C". Human Mutation 14 (3): 271. doi:10.1002/(SICI)1098-1004(1999)14:3<271::AID-HUMU14>3.0.CO;2-Q. PMID 10477438.
- Tang Y, Hu LA, Miller WE, Ringstad N, Hall RA, Pitcher JA, DeCamilli P, Lefkowitz RJ (Oct 1999). "Identification of the endophilins (SH3p4/p8/p13) as novel binding partners for the beta1-adrenergic receptor". Proceedings of the National Academy of Sciences of the United States of America 96 (22): 12559–64. doi:10.1073/pnas.96.22.12559. PMC 22990. PMID 10535961.
- Podlowski S, Wenzel K, Luther HP, Müller J, Bramlage P, Baumann G, Felix SB, Speer A, Hetzer R, Köpke K, Hoehe MR, Wallukat G (2000). "Beta1-adrenoceptor gene variations: a role in idiopathic dilated cardiomyopathy?". Journal of Molecular Medicine 78 (2): 87–93. doi:10.1007/s001090000080. PMID 10794544.
- Shiina T, Kawasaki A, Nagao T, Kurose H (Sep 2000). "Interaction with beta-arrestin determines the difference in internalization behavor between beta1- and beta2-adrenergic receptors". The Journal of Biological Chemistry 275 (37): 29082–90. doi:10.1074/jbc.M909757199. PMID 10862778.
- Hu LA, Tang Y, Miller WE, Cong M, Lau AG, Lefkowitz RJ, Hall RA (Dec 2000). "beta 1-adrenergic receptor association with PSD-95. Inhibition of receptor internalization and facilitation of beta 1-adrenergic receptor interaction with N-methyl-D-aspartate receptors". The Journal of Biological Chemistry 275 (49): 38659–66. doi:10.1074/jbc.M005938200. PMID 10995758.
- Börjesson M, Magnusson Y, Hjalmarson A, Andersson B (Nov 2000). "A novel polymorphism in the gene coding for the beta(1)-adrenergic receptor associated with survival in patients with heart failure". European Heart Journal 21 (22): 1853–8. doi:10.1053/euhj.1999.1994. PMID 11052857.
- Xu J, Paquet M, Lau AG, Wood JD, Ross CA, Hall RA (Nov 2001). "beta 1-adrenergic receptor association with the synaptic scaffolding protein membrane-associated guanylate kinase inverted-2 (MAGI-2). Differential regulation of receptor internalization by MAGI-2 and PSD-95". The Journal of Biological Chemistry 276 (44): 41310–7. doi:10.1074/jbc.M107480200. PMID 11526121.
- Hu LA, Chen W, Premont RT, Cong M, Lefkowitz RJ (Jan 2002). "G protein-coupled receptor kinase 5 regulates beta 1-adrenergic receptor association with PSD-95". The Journal of Biological Chemistry 277 (2): 1607–13. doi:10.1074/jbc.M107297200. PMID 11700307.
- Ranade K, Jorgenson E, Sheu WH, Pei D, Hsiung CA, Chiang FT, Chen YD, Pratt R, Olshen RA, Curb D, Cox DR, Botstein D, Risch N (Apr 2002). "A polymorphism in the beta1 adrenergic receptor is associated with resting heart rate". American Journal of Human Genetics 70 (4): 935–42. doi:10.1086/339621. PMC 379121. PMID 11854867.
Cell surface receptor: G protein-coupled receptors
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Class B: Secretin like
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Adhesion |
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Orphan |
- GPR (56
- 64
- 97
- 98
- 110
- 111
- 112
- 113
- 114
- 115
- 116
- 123
- 124
- 125
- 126
- 128
- 133
- 143
- 144
- 155
- 157)
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Other |
- Brain-specific angiogenesis inhibitor (1
- 2
- 3)
- Cadherin (1
- 2
- 3)
- Calcitonin
- CALCRL
- CD97
- Corticotropin-releasing hormone (1
- 2)
- EMR (1
- 2
- 3)
- Glucagon (GR
- GIPR
- GLP1R
- GLP2R)
- Growth hormone releasing hormone
- PACAPR1
- GPR
- Latrophilin (1
- 2
- 3
- ELTD1)
- Methuselah-like proteins
- Parathyroid hormone (1
- 2)
- Secretin
- Vasoactive intestinal peptide (1
- 2)
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Class C: Metabotropic glutamate / pheromone
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Taste |
- TAS1R (1
- 2
- 3)
- TAS2R (1
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- 4
- 5
- 7
- 8
- 9
- 10
- 13
- 14
- 16
- 19
- 20
- 30
- 31
- 38
- 39
- 40
- 41
- 42
- 43
- 45
- 46
- 50
- 60)
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Other |
- Calcium-sensing receptor
- GABA B (1
- 2)
- Glutamate receptor (Metabotropic glutamate (1
- 2
- 3
- 4
- 5
- 6
- 7
- 8))
- GPRC6A
- GPR (156
- 158
- 179)
- RAIG (1
- 2
- 3
- 4)
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Class F: Frizzled / Smoothened
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Frizzled |
- Frizzled (1
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- 3
- 4
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- 8
- 9
- 10)
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Smoothened |
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UpToDate Contents
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English Journal
- Chemistry, Physiology, and Pharmacology of β-Adrenergic Mechanisms in the Heart. Why are β-Blocker Antiarrhythmics Superior?
- Szentmiklosi AJ, Szentandrassy N, Hegyi B, Horvath B, Magyar J, Banyasz T, Nanasi PP1.
- Current pharmaceutical design.Curr Pharm Des.2015;21(8):1030-41.
- Stimulation of β-adrenergic receptors in the heart is the most effective endogenous way to increase the mechanical performance of cardiac tissues to meet the requirements of a fight-or-flight situation or stress. On the other hand, sustained activation of cardiac β-receptors initiates maladaptive
- PMID 25354180
- Physiological functions and pharmacological and toxicological effects of p-octopamine.
- Stohs SJ1.
- Drug and chemical toxicology.Drug Chem Toxicol.2015 Jan;38(1):106-12. doi: 10.3109/01480545.2014.900069. Epub 2014 Mar 24.
- Abstract p-Octopamine occurs naturally in plants, invertebrates and animals with diverse functions and effects. This review summarizes the chemistry, metabolism, receptor binding characteristics, known physiological functions, and pharmacological and toxicological effects of p-octopamine. Databases
- PMID 24654910
- Blood pressure lowering efficacy of partial agonist beta blocker monotherapy for primary hypertension.
- Wong GW1, Boyda HN, Wright JM.
- The Cochrane database of systematic reviews.Cochrane Database Syst Rev.2014 Nov 27;11:CD007450. doi: 10.1002/14651858.CD007450.pub2.
- BACKGROUND: Partial agonists are a subclass of beta blockers used to treat hypertension in many countries. Partial agonist act by stimulating beta receptors when they are quiescent and blocking beta receptors when they are active. The blood pressure (BP) lowering effect of partial agonist beta block
- PMID 25427719
Japanese Journal
- Beta-Blockade Restores Muscle Sympathetic Rhythmicity in Human Heart Failure
- KUBO Toshihiko,AZEVEDO Eduardo R,NEWTON Gary E,PICTON Peter,PARKER John D,FLORAS John S
- Circulation journal : official journal of the Japanese Circulation Society 75(6), 1400-1408, 2011-05-25
- … The current study tested the hypothesis that chronic therapy with lipophilic β-adrenoceptor antagonists augments the modulation of muscle sympathetic nerve activity variability (MSNAV) at this frequency range. … Beta-blockade increased the mean values for total power (from 0.00 to 0.50Hz; … 5.2±0.8 to 6.8±1.2U2; … P<0.001) and for harmonic MSNA spectral power across the 0.1-0.22Hz frequency range (from 0.48±0.10 to 1.50±0.32U2, F=12.2; …
- NAID 10028148880
- High concentrations of landiolol, a beta(1)-adrenoceptor antagonist, stimulate smooth muscle contraction of the rat trachea through the Rho-kinase pathway.
- SHIBATA OSAMU,NISHIOKA KENJI,YAMAGUCHI MASAKAZU,MAKITA TETSUJI,SUMIKAWA KOJI
- Journal of anesthesia 22(1), 21-26, 2008-02-20
- … In our preliminary study in rat tracheas, landiolol, a beta(1)-adrenoceptor antagonist, at high doses caused gradually progressing contraction, and this contraction reached a plateau after 20 min. Therefore, this study was carried out to clarify whether landiolol could stimulate the Rho-kinase pathway or the phosphatidylinositol (PI) response in the rat trachea. … Their tracheas were cut into 3-mm-wide ring segments or 1-mm-wide slices. …
- NAID 10024128507
Related Pictures
★リンクテーブル★
[★]
- 関
- adrenergic beta-1 receptor、beta-1 adrenoceptor、beta1 adrenergic receptor、beta1 adrenoceptor
[★]
- 英
- beta1 adrenoceptor、beta-1 adrenoceptor
- 関
- β1アドレナリン受容体
[★]
- 関
- adrenergic receptor、adrenoreceptor
[★]
β、ベータ
[★]