ベプリジル。塩酸ベプリジル
WordNet
- a complex consisting of an organic base in association with hydrogen chloride
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/02/24 22:00:36」(JST)
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Bepridil
|
| Systematic (IUPAC) name |
|
N-benzyl-N-(3-isobutoxy-2-pyrrolidin-1-yl-propyl)aniline
|
| Clinical data |
| Trade names |
Vascor |
| AHFS/Drugs.com |
monograph |
| MedlinePlus |
a699051 |
Pregnancy
category |
- US: C (Risk not ruled out)
|
Routes of
administration |
Oral |
| Pharmacokinetic data |
| Bioavailability |
Well absorbed |
| Protein binding |
99% |
| Metabolism |
Hepatic, CYP3A4-mediated |
| Biological half-life |
42 hours |
| Excretion |
Renal |
| Identifiers |
| CAS Number |
64706-54-3 Y |
| ATC code |
C08EA02 |
| PubChem |
CID 2351 |
| IUPHAR/BPS |
2337 |
| DrugBank |
DB01244 Y |
| ChemSpider |
2261 Y |
| UNII |
755BO701MA Y |
| ChEBI |
CHEBI:3061 Y |
| ChEMBL |
CHEMBL1008 Y |
| Chemical data |
| Formula |
C24H34N2O |
| Molar mass |
366.54 g/mol |
SMILES
-
O(CC(C)C)CC(N1CCCC1)CN(c2ccccc2)Cc3ccccc3
|
InChI
-
InChI=1S/C24H34N2O/c1-21(2)19-27-20-24(25-15-9-10-16-25)18-26(23-13-7-4-8-14-23)17-22-11-5-3-6-12-22/h3-8,11-14,21,24H,9-10,15-20H2,1-2H3 Y
-
Key:UIEATEWHFDRYRU-UHFFFAOYSA-N Y
|
| (verify) |
Bepridil (trade name Vascor) is an amine calcium channel blocker once used to treat angina. It is no longer sold in the United States.
It is nonselective.[1]
It has been discussed as a possible option in the treatment of atrial fibrillation.[2]
It has been implicated in causing ventricular arrhythmia (Torsades de pointes).
Ebola Research
In June 2015 a research paper [3] was published revealing Vascor (Bepridil) resulted in a 100% survival rate for mice exposed to Ebola during an experiment searching for potential pharmaceutical Ebola treatments; indicating its potential use in future Ebola research and therapy.[4]
References
- ^ Bezprozvanny I, Tsien RW (September 1995). "Voltage-dependent blockade of diverse types of voltage-gated Ca2+ channels expressed in Xenopus oocytes by the Ca2+ channel antagonist mibefradil (Ro 40-5967)". Mol. Pharmacol. 48 (3): 540–9. PMID 7565636.
- ^ Imai S, Saito F, Takase H; et al. (May 2008). "Use of bepridil in combination with Ic antiarrhythmic agent in converting persistent atrial fibrillation to sinus rhythm". Circ. J. 72 (5): 709–15. doi:10.1253/circj.72.709. PMID 18441448.
- ^ "A screen of approved drugs and molecular probes identifies therapeutics with anti–Ebola virus activity".
- ^ "Zoloft as Ebola cure? Antidepressant is one of a number of promising drugs being looked at by scientists.".
External links
- MedlinePlus DrugInfo medmaster-a697050
UpToDate Contents
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English Journal
- Ca²⁺ channel activators reveal differential L-type Ca²⁺ channel pharmacology between native and stem cell-derived cardiomyocytes.
- Kang J1, Chen XL, Ji J, Lei Q, Rampe D.
- The Journal of pharmacology and experimental therapeutics.J Pharmacol Exp Ther.2012 May;341(2):510-7. doi: 10.1124/jpet.112.192609. Epub 2012 Feb 21.
- Human stem cell-derived cardiomyocytes provide new models for studying the ion channel pharmacology of human cardiac cells for both drug discovery and safety pharmacology purposes. However, detailed pharmacological characterization of ion channels in stem cell-derived cardiomyocytes is lacking. Ther
- PMID 22353878
- The relationship between the plasma concentration of bepridil and its efficacy in the treatment of atrial fibrillation in Japanese patients.
- Noda K1, Gotoh Y, Tanioka S, Narayama Y, Kobayashi M, Iwai S, Katoh N, Tadano K.
- Biological & pharmaceutical bulletin.Biol Pharm Bull.2012;35(5):672-6.
- Bepridil hydrochloride is used for treatment of atrial fibrillation (AF) in Japan. We investigated the relationship between plasma concentrations of bepridil just before dosing (Cbep) and its clinical efficacy in Japanese patients (n=36) with AF. Patients were treated orally with 100, 150 or 200 mg/
- PMID 22687400
- An LC method for quantifying bepridil in human plasma using 1-naphthol as the internal standard.
- Noda K1, Narayama Y, Goto Y, Kobayashi M, Kuronuma H, Iwai S, Itoh K, Katoh N, Tadano K.
- Journal of chromatographic science.J Chromatogr Sci.2011 Aug;49(7):519-23.
- A modified method for the quantitative determination of bepridil hydrochloride in human plasma is described. This method is unrelated to chemical methods currently in use. The mobile phase is 50 mM phosphate buffer (pH3.0)-methanol-acetonitrile-triethylamine (57:3:40:1, v/v), and the samples are fra
- PMID 21801483
Japanese Journal
- イソプロテレノールが有効であった塩酸ベプリジルに伴うtorsades de pointesの1例
- The Relationship between the Plasma Concentration of Bepridil and Its Efficacy in the Treatment of Atrial Fibrillation in Japanese Patients
- The Resurfacing of Bepridil Hydrochloride on the World Stage as an Antiarrhythmic Drug for Atrial Fibrillation
Related Links
- View and buy high purity Bepridil hydrochloride from Tocris Bioscience, the leading worldwide supplier of high performance life science reagents ... Biological Activity Calcium channel blocker. Also inhibits Na + /Ca 2+ exchange ...
- ChemicalBook あなたのためにBepridil hydrochloride(74764-40-2)の化学的性質を提供して、融点、価格、蒸気圧、沸点、毒性、比重、沸点、密度、分子式、分子量、物理的な性質、毒性 税関のコードなどの情報、同時にあなたは更に ...
★リンクテーブル★
[★]
- 英
- bepridil
- 化
- 塩酸ベプリジル bepridil hydrochloride
- 商
- ベプリコール
- 関
- 抗不整脈薬
- 抗不整脈薬;非特異的チャネル遮断;フェニルアルキルアミン系
[★]
塩酸塩、ハイドロクロライド