ベプリジル
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/04/10 23:50:55」(JST)
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Bepridil
|
Systematic (IUPAC) name |
N-benzyl-N-(3-isobutoxy-2-pyrrolidin-1-yl-propyl)aniline
|
Clinical data |
Trade names |
Vascor |
AHFS/Drugs.com |
monograph |
MedlinePlus |
a699051 |
Pregnancy
category |
- US: C (Risk not ruled out)
|
Routes of
administration |
Oral |
Pharmacokinetic data |
Bioavailability |
Well absorbed |
Protein binding |
99% |
Metabolism |
Hepatic, CYP3A4-mediated |
Biological half-life |
42 hours |
Excretion |
Renal |
Identifiers |
CAS Number |
64706-54-3 Y |
ATC code |
C08EA02 (WHO) |
PubChem |
CID 2351 |
IUPHAR/BPS |
2337 |
DrugBank |
DB01244 Y |
ChemSpider |
2261 Y |
UNII |
755BO701MA Y |
ChEBI |
CHEBI:3061 Y |
ChEMBL |
CHEMBL1008 Y |
Chemical data |
Formula |
C24H34N2O |
Molar mass |
366.54 g/mol |
SMILES
-
O(CC(C)C)CC(N1CCCC1)CN(c2ccccc2)Cc3ccccc3
|
InChI
-
InChI=1S/C24H34N2O/c1-21(2)19-27-20-24(25-15-9-10-16-25)18-26(23-13-7-4-8-14-23)17-22-11-5-3-6-12-22/h3-8,11-14,21,24H,9-10,15-20H2,1-2H3 Y
-
Key:UIEATEWHFDRYRU-UHFFFAOYSA-N Y
|
(verify) |
Bepridil (trade name Vascor) is an amine calcium channel blocker once used to treat angina. It is no longer sold in the United States.
It is nonselective.[1]
It has been discussed as a possible option in the treatment of atrial fibrillation.[2]
It has been implicated in causing ventricular arrhythmia (torsades de pointes).
Ebola research
In June 2015 a research paper [3] was published finding bepridil to result in a 100% survival rate for mice exposed to ebola during an experiment searching for potential pharmaceutical ebola treatments; indicating its potential use in future ebola research and therapy.[4]
References
- ^ Bezprozvanny I, Tsien RW (September 1995). "Voltage-dependent blockade of diverse types of voltage-gated Ca2+ channels expressed in Xenopus oocytes by the Ca2+ channel antagonist mibefradil (Ro 40-5967)". Mol. Pharmacol. 48 (3): 540–9. PMID 7565636.
- ^ Imai S, Saito F, Takase H; et al. (May 2008). "Use of bepridil in combination with Ic antiarrhythmic agent in converting persistent atrial fibrillation to sinus rhythm". Circ. J. 72 (5): 709–15. doi:10.1253/circj.72.709. PMID 18441448.
- ^ "A screen of approved drugs and molecular probes identifies therapeutics with anti–Ebola virus activity".
- ^ "Zoloft as Ebola cure? Antidepressant is one of a number of promising drugs being looked at by scientists.".
External links
- MedlinePlus DrugInfo medmaster-a697050
UpToDate Contents
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English Journal
- Pharmacological conversion of atrial fibrillation in the patients of graves' disease.
- Kunii Y, Uruno T, Matsumoto M, Mukasa K, Noh J, Ito K, Akaishi M, Hori S, Nakazawa H.SourceIto Hospital, Department of Internal Medicine, 4-3-6 Jingumae, Shibuya-ku, Tokyo 150-8308, Japan. y-kidokoro@ito-hospital.jp.
- The Tokai journal of experimental and clinical medicine.Tokai J Exp Clin Med.2012 Dec 20;37(4):107-12.
- Background: Hyperthyroidism is one of the common causes of atrial fibrillation (AF), and AF is associated with increased morbidity and mortality due to thromboembolism. The sinus rhythm maintenance rate of hyperthyroidism-induced AF patients after conversion to sinus rhythm is excellent. The present
- PMID 23238902
- Role of the activation gate in determining the extracellular potassium dependency of block of HERG by trapped drugs.
- Pareja K, Chu E, Dodyk K, Richter K, Miller A.SourceCollege of Osteopathic Medicine; Touro University California; Vallejo, CA USA.
- Channels (Austin, Tex.).Channels (Austin).2012 Dec 6;7(1). [Epub ahead of print]
- Drug induced long QT syndrome (diLQTS) results primarily from block of the cardiac potassium channel HERG (human-ether-a-go-go related gene). In some cases long QT syndrome can result in the lethal arrhythmia torsade de pointes, an arrhythmia characterized by a rapid heart rate and severely compromi
- PMID 23221912
Japanese Journal
- ICD頻回作動時にVisible T-wave Altemansを認めたBrugada症候群の1例
- 左室基部後壁起源の心室性期外収縮により心室細動を繰り返した特発性心室細動の1例
- ベプリジルが原因と考えられた薬剤性間質性肺炎の1例
Related Links
- Bepridil (Vascor) is a drug prescribed to treat patients with angina. Side effects, drug interactions, and pregnancy safety information is included. ... Picture of Psoriasis A reddish, scaly rash often located over the surfaces of the ...
- Physician reviewed bepridil patient information - includes bepridil description, dosage and directions. ... Bepridil dosing information Usual Adult Dose for Angina Pectoris Prophylaxis: Initial dose: 200 mg orally once a day.
Related Pictures
★リンクテーブル★
[★]
- 英
- bepridil
- 化
- 塩酸ベプリジル bepridil hydrochloride
- 商
- ベプリコール
- 関
- 抗不整脈薬
- 抗不整脈薬;非特異的チャネル遮断;フェニルアルキルアミン系
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ベプリジル。塩酸ベプリジル