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1. ベンゾジアゼピン依存症：疫学、発症機序、臨床症状、経過、診断benzodiazepine use disorder epidemiology pathogenesis clinical manifestations course and diagnosis [show details]
… signs of benzodiazepine misuse . High rates of misuse of benzodiazepines have also been found among injection drug users and those receiving methadone maintenance treatment . Benzodiazepine use disorder …
2. ベンゾジアゼピンの中毒および離脱benzodiazepine poisoning and withdrawal [show details]
… sedation . However, successive doses of midazolam lead to bioaccumulation of its hydroxy-metabolites and may prolong the drug sedative effects . Oral benzodiazepines (BZD), taken in overdose without a coingestant …
3. 危篤状態の成人における鎮静鎮痛剤：特性、投与レジメン、および副作用sedative analgesic medications in critically ill adults properties dosage regimens and adverse effects [show details]
… increase systemic blood pressure may enhance dexmedetomidine hypertensive effect. Midazolam and lorazepam are the benzodiazepines that are best suited for sedation in the intensive care unit (ICU) because they …
4. 成人における痙攣性のてんかん重積状態：治療および予後convulsive status epilepticus in adults treatment and prognosis [show details]
… patients who are actively seizing despite two initial doses of lorazepam or other benzodiazepine, preparation for a continuous midazolam or propofol infusion should occur simultaneously with administration …
5. 成人における全般性不安障害の治療法に対するアプローチapproach to treating generalized anxiety disorder in adults [show details]
…drug effects, a low-dose benzodiazepine (eg, lorazepam 1 to 2 mg/day in divided doses) can be added adjunctively. In a trial where the patient responds to an SRI, the benzodiazepine can typically be tapered …

English Journal

Mistaking 2C-P for 2C-B: What a Difference a Letter Makes.

Stoller A, Dolder PC, Bodmer M, Hammann F, Rentsch KM, Exadaktylos AK, Liechti ME, Liakoni E.
Journal of analytical toxicology. 2017 Jan;41(1)77-79.
2,5-Dimethoxy-4(n)-propylphenethylamine (2C-P) is a synthetic phenethylamine derivative belonging to the large family of the so-called 2C drugs. These compounds can differ significantly in receptor affinity, potency and duration of action, and an important structural difference is the ligand in the
PMID 28130544

Severe poisoning after self-reported use of 2-(4-iodo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine, a novel substituted amphetamine: a case series.

Hieger MA, Rose SR, Cumpston KL, Stromberg PE, Miller S, Wills BK.
The American journal of emergency medicine. 2015 Dec;33(12)1843.e1-3.
Significant toxicity from amphetamine and cathinone derivatives is being increasingly reported. We describe a series of self-reported exposures to 2-(4-iodo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine (25-I-NBOME or 25-I), a novel amphetamine derivative. Ten patients with an average a
PMID 25983267

Poor Man's Methadone: A Case Report of Loperamide Toxicity.

Dierksen J, Gonsoulin M, Walterscheid JP.
The American journal of forensic medicine and pathology. 2015 Dec;36(4)268-70.
Loperamide, a common over-the-counter antidiarrheal drug and opioid derivative, is formulated to act upon intestinal opioid receptors. However, at high doses, loperamide crosses the blood-brain barrier and reaches central opioid receptors in the brain, leading to central opiate effects including eup
PMID 26355852

Japanese Journal

わが国における三次救急医療施設と科警研資料の急性ベンゾジアゼピン系薬物中毒の解析-1996

平田清貴,松本宜明,松本光雄,村田正弘,黒川顕
日本救急医学会雑誌 10(11), 657-666, 1999
わが国における急性ベンゾジアゼピン系薬物の重篤,かつ致死的な中毒の実態を解明することを目的として,1996年の1月から12月において,日本の59の三次救急医療施設に受け入れられた669人の急性ベンゾジアゼピン系薬物中毒症例と,同一期間における日本の27の都道府県警察管区(58.7%の都道府県に発生した)におけるベンゾジアゼピン系薬物を服用し,死亡した95例の法医学的検死例について解析し検討を行った …
NAID 130003625695