benign infantile seizures

乳児良性痙攣

WordNet

1. not dangerous to health; not recurrent or progressive (especially of a tumor)
2. pleasant and beneficial in nature or influence; "a benign smile"; "the benign sky"; "the benign influence of pure air" (同)benignant
3. kindness of disposition or manner; "the benign ruler of millions"; "benign intentions"
4. of or relating to infants or infancy; "infantile paralysis"
5. being or befitting or characteristic of an infant; "infantile games"
6. a sudden occurrence (or recurrence) of a disease; "he suffered an epileptic seizure" (同)ictus, raptus
7. the taking possession of something by legal process

PrepTutorEJDIC

1. (心・表情などが)親切な,優しい / (事情・環境・気候などが)好適な,好都合な / 悪性でない
2. 《名詞の前にのみ用いて》幼時の / 子供じみた;子供らしい
3. 〈U〉〈C〉つかむ(つかまれる)こと / 〈U〉〈C〉強奪;差し押さえ;逮捕 / 〈C〉(病気・恐怖などが)襲うこと,発作

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/03/15 10:35:45」(JST)

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Benign infantile epilepsy (BIE), also known as benign infantile seizures (BIS), is an epilepsy syndrome of which several forms have been described. The International League Against Epilepsy (ILAE) classify two main forms of the syndrome (familial and nonfamilial) though several other forms have been described in the academic literature. Affected children, who have no other health or developmental problems, develop seizures during infancy. These seizures have focal origin within the brain but may then spread to become generalised seizures. The seizures may occur several times a day, often grouped in clusters over one to three days followed by a gap of one to three months. Treatment with anticonvulsant drugs is not necessary but they are often prescribed and are effective at controlling the seizures. This form of epilepsy resolves after one or two years, and appears to be completely benign. The EEG of these children, between seizures, is normal. The brain appears normal on MRI scan

The familial and nonfamilial forms have overlapping features and the presence of a family history of infantile seizures may be the only distinguishing criterion. The nonfamiliar form has a larger range of the onset of seizures: from three to twenty months with most occurring between five and six months. There is no difference between the sexes. With benign familial infantile epilepsy, the seizures onset from four to eight months of age.

Some cases of nonfamilial benign infantile seizures occur during a case of mild gastroenteritis. Called benign infantile seizures associated with mild gastroenteritis (BIS with MG), the seizures only occur during this illness and no not recur. Infection with rotavirus is the most common cause.

Although children with benign infantile epilepsy typically have a normal EEG between seizures, some infants have been found to have a characteristic abnormal EEG during sleep. Called benign infantile focal epilepsy with midline spikes and waves during sleep, these infants have few seizures and there may often be a family history.

References

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• 1. 小児期の良性焦点性てんかん benign focal epilepsies of childhood
• 2. 小児におけるてんかん症候群 epilepsy syndromes in children
• 3. 小児における痙攣およびてんかん：分類、病因、および臨床的特徴 seizures and epilepsy in children classification etiology and clinical features
• 4. 幼児および小児における痙攣発作の臨床検査診断 clinical and laboratory diagnosis of seizures in infants and children
• 5. 局在関連（焦点性）てんかん：原因および臨床的特徴 localization related focal epilepsy causes and clinical features

English Journal

• Focal seizures and epileptic spasms in a child with Down syndrome from a family with a PRRT2 mutation.

• Igarashi A1, Okumura A2, Shimojima K3, Abe S4, Ikeno M4, Shimizu T4, Yamamoto T3.
• Brain & development.Brain Dev.2016 Jun;38(6):597-600. doi: 10.1016/j.braindev.2015.12.011. Epub 2016 Feb 8.
• We describe a girl with Down syndrome who experienced focal seizures and epileptic spasms during infancy. The patient was diagnosed as having trisomy 21 during the neonatal period. She had focal seizures at five months of age, which were controlled with phenobarbital. However, epileptic spasms appea
• PMID 26867511

• Whole-gene duplication of SCN2A and SCN3A is associated with neonatal seizures and a normal intellectual development.

• Thuresson AC1, Van Buggenhout G2, Sheth F3, Kamate M4, Andrieux J5, Clayton Smith J6,7, Soussi Zander C1.
• Clinical genetics.Clin Genet.2016 May 6. doi: 10.1111/cge.12797. [Epub ahead of print]
• Duplications at 2q24.3 encompassing the voltage-gated sodium channel gene cluster are associated with early onset epilepsy. All cases described in the literature have presented in addition with different degrees of intellectual disability, and have involved neighbouring genes in addition to the sodi
• PMID 27153334

• Autosomal dominant SCN8A mutation with an unusually mild phenotype.

• Anand G1, Collett-White F2, Orsini A2, Thomas S2, Jayapal S3, Trump N4, Zaiwalla Z2, Jayawant S2.
• European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society.Eur J Paediatr Neurol.2016 Apr 30. pii: S1090-3798(16)30019-8. doi: 10.1016/j.ejpn.2016.04.015. [Epub ahead of print]
• BACKGROUND: Mutations in SCN8A, coding for the voltage-gated sodium channel Nav 1.6, have been described in relation to infantile onset epilepsy with developmental delay and cognitive impairment, in particular early onset epileptic encephalopathy (EIEE) type 13.CASE REPORT: Here we report an infant
• PMID 27210545

Japanese Journal

• Treatment of benign focal epilepsies in children : When and how should be treated?

• Brain & development 33(3), 207-212, 2011-03-01
• NAID 10029560796

• Benign familial and non-familial infantile seizures (Fukuyama-Watanabe-Vigevano syndrome) : A study of 14 cases from Saudi Arabia

• Brain & development 32(5), 378-384, 2010-05-01
• NAID 10027491371

• てんかん,良性乳児けいれん,機会関連発作 (特集 けいれん・意識障害119番--まず考えるべきことと対応) -- (重要な疾患の具体例--診断と治療)

• 小児科診療 71(3), 472-476, 2008-03
• NAID 40015859015

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★リンクテーブル★

リンク元	「乳児良性痙攣」
関連記事	「infantile」「benign」「seizure」

「乳児良性痙攣」

　　[★]

英

benign infantile seizures

「infantile」

　　[★]

• adj.

• 乳児性の、乳児の、小児性の、小児型の

関

baby、infant、newborn infant、puerility、suckling、sucklings

　 　 　

「benign」

　　[★]

• adj.

• 良性の、穏和な

関

benignant、mild、mildly

　 　 　 　

「seizure」

　　[★] てんかん発作