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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/10/22 21:42:25」(JST)

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Benazepril, brand name Lotensin (Novartis), is a medication used to treat high blood pressure (hypertension), congestive heart failure, and chronic renal failure. Upon cleavage of its ester group by the liver, benazepril is converted into its active form benazeprilat, a non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor.

Dosage forms

Benazepril is available as oral tablets, in 5-, 10-, 20-, and 40-mg doses.

Benazepril is also available in combination with hydrochlorothiazide, under the trade name Lotensin HCT, and with amlodipine (trade name Lotrel).

Side effects

Most commonly, headaches and cough can occur with its use. Anaphylaxis, angioedema and hyperkalemia, the elevation of potassium levels, can also occur.

Benazepril may cause harm to the fetus during pregnancy.

Contraindications

Benazepril should be discontinued during pregnancy.

Kidney disease

According to a 2006 article in the New England Journal of Medicine, patients with advanced renal insufficiency taking benazepril showed "substantial" kidney benefits.^[1]

A long-term study of patients' kidney disease revealed patients who took benazepril had better kidney function and slower progressions of kidney disease than their peers who took a placebo drug.^[2] This is notable because this category of pharmaceuticals has long been thought to cause further kidney damage or increase the rate of progression for kidney disease.

According to coverage of the study on WebMD:

“

ACE inhibitors can pose a potential threat to kidneys as well. The key question was whether damaged kidneys would worsen if patients took ACE inhibitors. In a nutshell, concerns centered on blood levels of potassium and creatinine, waste products that are excreted by the kidneys. Testing creatinine levels in the blood is used as a way to monitor kidney function (...) kidney problems worsened more slowly in those taking Lotensin. Overall, there were no major differences in side effects between patients taking Lotensin or the placebo.^[2]

”

This study marks the first indication that benazepril, and perhaps other ACE inhibitors, may actually be beneficial in the treatment of hypertension in patients with kidney disease.

Veterinary use

Under the brand names Fortekor (Novartis) and VetACE (Jurox Animal Health), benazepril hydrochloride is used to treat congestive heart failure in dogs and chronic renal failure in dogs and cats.

References

^ Hou F, Zhang X, Zhang G, Xie D, Chen P, Zhang W, Jiang J, Liang M, Wang G, Liu Z, Geng R (2006). "Efficacy and safety of benazepril for advanced chronic renal insufficiency". N Engl J Med 354 (2): 131–40. doi:10.1056/NEJMoa053107. PMID 16407508.
^ ^a ^b Hitti, Miranda; Chang, Louise (January 11, 2006). "Drug May Treat Advanced Kidney Disease". WebMD. http://www.webmd.com/content/article/117/112524.htm. Retrieved 2006-09-07.

External links

Prescribing Information for Lotensin

UpToDate Contents

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1. Choice of drug therapy in primary (essential) hypertension
2. 成人の非糖尿病性慢性腎臓病患者に対する降圧療法と病状の進展 antihypertensive therapy and progression of nondiabetic chronic kidney disease in adults
3. 高齢者における高血圧、特に収縮期高血圧の治療 treatment of hypertension in the elderly patient particularly isolated systolic hypertension
4. 黒人における高血圧治療 treatment of hypertension in blacks
5. 高血圧治療におけるレニン・アンギオテンシン系阻害 renin angiotensin system inhibition in the treatment of hypertension

English Journal

Qufeng Tongluo Prescription () inhibits mesangial cell proliferation and promotes apoptosis through regulating cell cycle progression.

Wu XL, An P, Ye BY, Shi XM, Sun WS, Fu RG, Wang Z, Qiao CL.SourceDepartment of Integrated Traditional Chinese and Western Medicine, Second Affiliated Hospital of Medical School of Xi'an Jiaotong University, Xi'an, 710004, China, wuxili1984@163.com.
Chinese journal of integrative medicine.Chin J Integr Med.2013 Dec;19(12):927-34. doi: 10.1007/s11655-013-1655-8. Epub 2013 Dec 5.
OBJECTIVE: To study the effects and possible underlying mechanism of Qufeng Tongluo Prescription (, QFTL) on the regulation of mesangial cells (MCs) proliferation and apoptosis.METHODS: The MCs used in this experiment have undergone five passages induced by lipopolysaccharide (LPS). Changes in the p
PMID 24307313

The loading and release properties of a novel drug carrier for benazepril based on nano graphene oxide.

Long Y, Wang J, Tao CA, Zhu H, Lv Y, Li N.SourceCollege of Science, National University of Defense Technology, Changsha 410073, China.
Journal of controlled release : official journal of the Controlled Release Society.J Control Release.2013 Nov 28;172(1):e88-9. doi: 10.1016/j.jconrel.2013.08.180.
PMID 24242609

A mechanistic study on the loading of benazepril onto graphene oxide and its release.

Wang J, Qin S, Long Y, Tao CA, Lv Y, Zhu H.SourceCollege of Science, National University of Defense Technology, Changsha 410073, China. Electronic address: wangjianfang@nudt.edu.cn.
Journal of controlled release : official journal of the Controlled Release Society.J Control Release.2013 Nov 28;172(1):e39-40. doi: 10.1016/j.jconrel.2013.08.085.
PMID 24242515

Japanese Journal

重度の反復する下部消化管出血に対して大腸血管拡張症を疑った犬の1例

近澤征史朗,畑井仁,後藤晃伸
日本獣医師会雑誌 67(10), 767-772, 2014
7歳齢，雌のミニチュア・ダックスフンドが血便を伴う進行性の貧血を主訴に来院した．内視鏡検査にて下行結腸から上行結腸にかけて粘膜血管の拡張や充出血が認められた．抗生物質，免疫抑制剤による治療を行うも症状の明らかな改善は認められず，頻回の輸血処置を要した．内視鏡下生検による病理組織学的検索では大腸粘膜における軽度の血管拡張が示唆されたため，大腸血管拡張症（colonic vascular ectasi …
NAID 130004709672

心エコー検査により診断した三尖弁異形成の猫の1例

華園究,福本真也,布施辰樹,石井俊治,打出毅
動物臨床医学 = Journal of Animal Clinical Research Foundation 22(1), 26-30, 2013-03-20
胸水貯留のため来院した4歳の雑種猫に超音波検査を実施したところ，右心房および右心室の拡大，三尖弁逆流，短縮した中隔尖，短縮した腱索，心室中隔奇異性運動，もやもやエコーが認められた。三尖弁の形態的特徴から三尖弁異形成と診断した。ベナゼプリル，ピモベンダン，フロセミド，スピロノラクトンおよびダルテパリンにて治療を行ったが状態の改善は得られず，第14病日に死亡した。
NAID 10031161907

Simultaneous Determination of Amlodipine Besylate and Benazepril Hydrochloride in Pharmaceutical Dosage Form by LC

Kasawar Gajanan B.,Farooqui Mazahar N.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 25(12), 1495-1498, 2009-12-10
… A rapid, precise, specific, and accurate ultra performance liquid chromatography (UPLC) method has been developed and subsequently validated for simultaneous determination of amlodipine present as amlodipine basylate (AB) and benazepril hydrochloride (BH) in capsule dosage form. …
NAID 10026780780

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★リンクテーブル★

リンク元	「ベナゼプリル」
拡張検索	「benazepril hydrochloride」

「ベナゼプリル」

Benazepril
Systematic (IUPAC) name
	2-[(3S)-3-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}-
Clinical data
Trade names	Lotensin
AHFS/Drugs.com	monograph
MedlinePlus	a692011
Pregnancy cat.	D
Legal status	℞ Prescription only
Routes	Oral
Pharmacokinetic data
Protein binding	96.7%
Metabolism	Hepatic glucuronidation
Half-life	10-11 hours
Excretion	Renal and biliary
Identifiers
CAS number	86541-75-5
ATC code	C09AA07
PubChem	CID 5362124
DrugBank	DB00542
ChemSpider	4514935
UNII	UDM7Q7QWP8
ChEBI	CHEBI:3011
ChEMBL	CHEMBL838
Chemical data
Formula	C24H28N2O5
Mol. mass	424.49 g/mol
	SMILES O=C(OCC)[C@@H](N[C@@H]2C(=O)N(c1ccccc1CC2)CC(=O)O)CCc3ccccc3;
	InChI InChI=1S/C24H28N2O5/c1-2-31-24(30)20(14-12-17-8-4-3-5-9-17)25-19-15-13-18-10-6-7-11-21(18)26(23(19)29)16-22(27)28/h3-11,19-20,25H,2,12-16H2,1H3,(H,27,28)/t19-,20-/m0/s1 ; Key:XPCFTKFZXHTYIP-PMACEKPBSA-N ;
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　　[★]

英: benazepril
化: 塩酸ベナゼプリル、benazepril hydrochloride
商: ベナゼップ、タツジピン、チバセン

「benazepril hydrochloride」

　　[★] ベナゼプリル、塩酸ベナゼプリル

[Hou-0] Hou F, Zhang X, Zhang G, Xie D, Chen P, Zhang W, Jiang J, Liang M, Wang G, Liu Z, Geng R (2006). "Efficacy and safety of benazepril for advanced chronic renal insufficiency". N Engl J Med 354 (2): 131–40. doi:10.1056/NEJMoa053107. PMID 16407508.

[Hitti-1] Hitti, Miranda; Chang, Louise (January 11, 2006). "Drug May Treat Advanced Kidney Disease". WebMD. http://www.webmd.com/content/article/117/112524.htm. Retrieved 2006-09-07.

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benazepril