WordNet

the tendency of cells to stain with basic dyes; "cytoplasmic basophilia"
a leukocyte with basophilic granules easily stained by basic stains (同)basophile

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/12/24 02:21:33」(JST)

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Basophilia is a condition where the basophil quantity is abnormally elevated (more than 10¹⁰ basophils per liter of blood).^[1]

Causes

Basophilia as an isolated finding is uncommon. However it is a common feature of myeloproliferative disorders and particularly prominent in chronic myelogenous leukemia.^[2]^[3]

Conditions Associated with Alterations in Numbers of Blood Basophils

I. Decreased Numbers (Basopenia)

 A. Hereditary absence of basophils (very rare)
 B. Elevated levels of glucocorticoids
 C. Hyperthyroidism or treatment with thyroid hormones
 D. Ovulation
 E. Hypersensitivity reactions
   1. Urticaria
   2. Anaphylaxis
   3. Drug-induced reactions
 F. Leukocytosis (in association with diverse disorders)

II. Increased Numbers (Basophilia)

 A. Allergy or inflammation
   1. Ulcerative colitis
   2. Drug, food, inhalant hypersensitivity
   3. Erythroderma, urticaria
   4. Juvenile rheumatoid arthritis
 B. Endocrinopathy
   1. Diabetes mellitus
   2. Estrogen administration
   3. Hypothyroidism (myxedema)
 C. Infection
   1. Chicken pox
   2. Influenza
   3. Smallpox
   4. Tuberculosis
 D. Iron deficiency
 E. Exposure to ionizing radiation
 F. Neoplasia
   1. "Basophilic leukemia" (see text)
 G. Myeloproliferative neoplasms (especially chronic myelogenous leukemia; also polycythemia vera, primary myelofibrosis, essential thrombocythemia)
 H. Carcinoma

References

^ "Cytoplasmic basophilia". Veterinary Clinical Pathology Image Database. University of Montreal Veterinary College. Retrieved 2008-09-20.
^ Ravandi, F.; R. Hoffman (2005). "Chapter 17. Phagocytes". In A.V. Hoffbrand; et al. Postgraduate Haematology. Boston: Blackwell Publishing. pp. 296–298. ISBN 1-4051-0821-5.
^ Table 12-6 in: Mitchell, Richard Sheppard; Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson. Robbins Basic Pathology. Philadelphia: Saunders. ISBN 1-4160-2973-7. 8th edition.

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English Journal

Heparin-mediated inhibition of PCR in the accelerated phase of chronic myeloid leukaemia characterized by abundant basophilia.

Satoh Y, Masuda A, Jona M, Nannya Y, Yokota H, Kurokawa M, Yatomi Y.Author information Department of Clinical Laboratory, The University of Tokyo Hospital, Tokyo, Japan.AbstractMeasurement of BCR-ABL1 transcript levels using reverse transcription polymerase chain reaction (RT-PCR) is important for assessing minimal residual disease (MRD) in chronic myeloid leukaemia (CML) (1). Here, we report two cases of BCR-ABL1-positive CML in which PCR amplification of the gene was inhibited.Patient 1 was an 82-year-old woman diagnosed as having CML-chronic phase (CP), who had been started on treatment with imatinib. This article is protected by copyright. All rights reserved.
European journal of haematology.Eur J Haematol.2013 Dec 26. doi: 10.1111/ejh.12259. [Epub ahead of print]
Measurement of BCR-ABL1 transcript levels using reverse transcription polymerase chain reaction (RT-PCR) is important for assessing minimal residual disease (MRD) in chronic myeloid leukaemia (CML) (1). Here, we report two cases of BCR-ABL1-positive CML in which PCR amplification of the gene was inh
PMID 24373003

The effect of short-term vitamin E against radioiodine-induced early lacrimal gland damage.

Acar U, Atilgan HI, Acar DE, Yalniz-Akkaya Z, Yumusak N, Korkmaz M, Koca G.Author information Department of Ophthalmology, Kastamonu Faculty of Medicine, Hacettepe University, Kazakistan Caddesi 90/7 Emek, 06500, Ankara, Turkey, druguracar@gmail.com.AbstractRadioiodine (RAI) is a well-known radionuclide which is used in vivo both for diagnostic and therapeutic purposes, particularly for the treatment of hyperthyroidism and thyroid cancer. Vitamin E is a well-known antioxidant vitamin. The aim of this study was to evaluate whether there was a protective effect of short-term vitamin E on RAI-induced lacrimal gland early damage in experimental animal models.
Annals of nuclear medicine.Ann Nucl Med.2013 Dec;27(10):886-91. doi: 10.1007/s12149-013-0763-z. Epub 2013 Aug 27.
Radioiodine (RAI) is a well-known radionuclide which is used in vivo both for diagnostic and therapeutic purposes, particularly for the treatment of hyperthyroidism and thyroid cancer. Vitamin E is a well-known antioxidant vitamin. The aim of this study was to evaluate whether there was a protective
PMID 23979966

Myxochondroid metaplasia of the plantar foot: a distinctive pseudoneoplastic lesion resembling nuchal fibrocartilaginous pseudotumor and the equine digital cushion.

Shon W, Folpe AL.Author information Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.AbstractCartilaginous tumors of soft tissue are uncommon, with benign chondromas of soft parts greatly outnumbering rare soft-tissue chondrosarcomas. Over the past several years, we have seen in consultation a distinctive, benign-appearing chondroid soft-tissue lesion of the plantar foot that differs in a number of respects from chondroma of soft parts. Herein we report our experience with this distinctive lesion. A retrospective review of all cases from the foot in our soft-tissue consultation and institutional surgical pathology archives identified 9 similar cases, most often previously coded as 'fibroconnective tissue with chondroid metaplasia'. Six cases were submitted in consultation due to concern for a neoplastic process, in particular chondroma of soft parts or fibro-osseous pseudotumor of the digits. The patients were 4 young males (age range 8-16 years, mean 11.5 years) and 5 older patients, including 4 women and 1 man (age range 34-78 years, mean 56.4 years). All cases occurred in the subcutaneous plantar soft tissues of the feet, including four cases confined to the toes, and presented as non-specific, variably painful masses. Radiographic studies, available in six cases, did not show any evidence of bone involvement. Histologically, the lesions were characterized by a partially circumscribed, variably cellular proliferation of bland fibroblastic cells in a fibromyxoid background in areas showing distinct stromal basophilia and a chondroid appearance. Small foci of true cartilaginous metaplasia with lacuna formation were occasionally seen. Cartilaginous differentiation was confirmed in three cases with immunohistochemistry for S100 and ERG proteins. Intralesional cystic change was common, as were a variety of other reactive-appearing changes in the surrounding connective tissue. Characteristic morphological features of chondroma of soft parts and/or fibro-osseous pseudotumor of the digits were absent. Clinical follow-up (7 patients, 2-115 months, median 38 months) showed all patients to be without recurrent disease. We have identified a morphologically distinctive lesion of the foot that appears to represent a reactive, metaplastic process, presumably secondary to chronic mechanical stress. The morphological features of myxochondroid metaplasia of the plantar foot are reminiscent of those of nuchal fibrocartilaginous pseudotumor and the equine digital cushion, further suggesting a reactive/reparative etiology. Awareness of the unique features of this lesion should allow its ready distinction from other neoplastic and pseudoneoplastic (osteo) cartilaginous lesions of the feet.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.Mod Pathol.2013 Dec;26(12):1561-7. doi: 10.1038/modpathol.2013.116. Epub 2013 Jun 14.
Cartilaginous tumors of soft tissue are uncommon, with benign chondromas of soft parts greatly outnumbering rare soft-tissue chondrosarcomas. Over the past several years, we have seen in consultation a distinctive, benign-appearing chondroid soft-tissue lesion of the plantar foot that differs in a n
PMID 23765248

Japanese Journal

Isolated Isochromosome 17q in Myelodysplastic Syndromes with Pure Red Cell Aplasia and Basophilia

Inui Yumiko,Yamamoto Katsuya,Okamura Atsuo,Yakushijin Kimikazu,Hayashi Yoshitake,Matsuoka Hiroshi,Minami Hironobu
Internal Medicine 51(12), 1579-1584, 2012
Myelodysplastic syndromes (MDS) with pure red cell aplasia (PRCA) have been shown to be a rare form of MDS. A 35-year-old man presented with pancytopenia: hemoglobin 59 g/L, reticulocytes 2×109/L, pla …
NAID 130002062172

Chronic Myelogenous Leukemia with Mild Basophilia as the Predominant Manifestation at Presentation

Yasuda Hajime,Aritaka Nanae,Ando Jun,Hirama Michihiro,Komatsu Norio,Hirano Takao
Internal Medicine 50(5), 501-502, 2011
… Chronic myelogenous leukemia (CML) is a clonal hematological malignancy typically presenting with basophilia and massive proliferation of differentiating myeloid cells. … We report an atypical case of CML in which mild basophilia was the sole manifestation at presentation, and the condition persisted for 27 months with no sign of progression. …
NAID 130000649868

Schistosome eggs have a direct role in the induction of basophils capable of a high level of IL-4 production : Comparative study of single- and bisexual infection of Schistosoma mansoni in vivo

ANYAN William K.,KUMAGAI Takashi,SHIMOGAWARA Rieko F.,SEKI Takenori,AKAO Nobuaki,OBATA Kazushige,KWANSA-BENTUM Bethel,BOSOMPEM Kwabena Mante,BOAKYE Daniel A,WILSON Michael D.,KARASUYAMA Hajime,OHTA Nobuo
Tropical medicine and health 38(1), 13-22, 2010-03-01
… Injection of eggs induced basophilia, and it was accompanied by the up-regulation of IL-4 production in splenocytes from the 8<SUP>th</SUP> …
NAID 10026420055