WordNet

a shape that is generated by rotating an ellipse around one of its axes; "it looked like a sphere but on closer examination I saw it was really a spheroid" (同)ellipsoid of revolution
long nerve fiber that conducts away from the cell body of the neuron (同)axone
of or relating to or resembling an axon

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Mutations in RAB39B Cause X-Linked Intellectual Disability and Early-Onset Parkinson Disease with α-Synuclein Pathology.

Wilson GR1, Sim JC2, McLean C3, Giannandrea M4, Galea CA5, Riseley JR2, Stephenson SE1, Fitzpatrick E2, Haas SA6, Pope K2, Hogan KJ7, Gregg RG8, Bromhead CJ9, Wargowski DS10, Lawrence CH11, James PA12, Churchyard A13, Gao Y2, Phelan DG1, Gillies G2, Salce N2, Stanford L14, Marsh AP1, Mignogna ML4, Hayflick SJ14, Leventer RJ15, Delatycki MB16, Mellick GD17, Kalscheuer VM18, D'Adamo P19, Bahlo M20, Amor DJ1, Lockhart PJ21.
American journal of human genetics.Am J Hum Genet.2014 Dec 4;95(6):729-35. doi: 10.1016/j.ajhg.2014.10.015. Epub 2014 Nov 26.
Advances in understanding the etiology of Parkinson disease have been driven by the identification of causative mutations in families. Genetic analysis of an Australian family with three males displaying clinical features of early-onset parkinsonism and intellectual disability identified a ∼45 kb
PMID 25434005

Targeted GAS6 Delivery to the CNS Protects Axons from Damage during Experimental Autoimmune Encephalomyelitis.

Gruber RC1, Ray AK1, Johndrow CT2, Guzik H3, Burek D1, de Frutos PG4, Shafit-Zagardo B5.
The Journal of neuroscience : the official journal of the Society for Neuroscience.J Neurosci.2014 Dec 3;34(49):16320-35. doi: 10.1523/JNEUROSCI.2449-14.2014.
Growth arrest-specific protein 6 (GAS6) is a soluble agonist of the TYRO3, AXL, MERTK (TAM) family of receptor tyrosine kinases identified to have anti-inflammatory, neuroprotective, and promyelinating properties. During experimental autoimmune encephalomyelitis (EAE), wild-type (WT) mice demonstrat
PMID 25471571

齋藤万有
臨床神経学 54(12), 1162-1164, 2014
… Hereditary diffuse leukoencephalopathy with axonal spheroids（HDLS）は病理学的に大脳に多数の軸索腫大（spheroid）の出現を特徴とする常染色体優性遺伝性白質脳症である．近年，本疾患の原因としてcolony stimulating factor 1受容体（CSF-1R）の遺伝子変異が同定され，ミクログリアの機能異常が本症の病態として明らかにされつつある．本疾患は一次進行型多発性硬化症（Primary progressive multiple sclerosis; …
NAID 130004921227

植田明彦,安東由喜雄
臨床神経学 54(12), 1168-1170, 2014
HDLSとCADASILは共に常染色体優性の遺伝性白質脳症である．HDLSが前頭葉機能障害や認知症で発症する事に対し，CADASILでは片頭痛や脳梗塞で発症する．また，CADASILでは有病率の高い若年発症の脳梗塞の家族歴が重要である．CADASILは側頭極白質病変が特異的であるが，本病変を欠くばあいもあり，家族歴，その他の画像所見より総合的な診断が必要なばあいもある．共に半卵円中心に病変ができる …
NAID 130004921167