WordNet

not representative of a group, class, or type; "a group that is atypical of the target audience"; "a class of atypical mosses"; "atypical behavior is not the accepted type of response that we expect from children" (同)untypical
deviating from normal expectations; somewhat odd, strange, or abnormal; "these days large families are atypical"; "atypical clinical findings"; "atypical pneumonia"; "highly irregular behavior" (同)irregular
an agranulocytic leukocyte that normally makes up a quarter of the white blood cell count but increases in the presence of infection (同)lymph cell

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型にはまらない,異常な

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/08/16 02:47:04」(JST)

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Reactive lymphocyte surrounded by red blood cells.

Reactive lymphocytes are lymphocytes that become large as a result of antigen stimulation. Typically they can be more than 30 µm in diameter with varying size and shape.

The nucleus of a reactive lymphocyte can be round, elliptic, indented, cleft or folded. The cytoplasm is often abundant and can be basophilic. Vacuoles and/or azurophilic granules are also sometimes present. Most often the cytoplasm is gray, pale blue or deep blue in colour.

The distinctive cell associated with EBV or CMV is known as a "Downey cell", after Hal Downey, who contributed to the characterization of it in 1923.^[1]^[2] It is sometimes erroneously called a "Downy cell".^[3]

Causes

Reactive lymphocytes are usually associated with viral illnesses, however, they can also be present as a result of drug reactions (such as phenytoin), immunisations, radiation, hormonal causes (such as stress and Addison's disease) as well as some auto-immune disorders (such as rheumatoid arthritis).

Some pathogen-related causes include:

Epstein-Barr virus
Cytomegalovirus
Toxoplasma gondi
Treponema pallidum (Syphilis)
Streptococcus agalactiae (Group B Streptococci),
Hepatitis C
Hantavirus^[4]

References

^ Cabot, Richard C.; Scully, Robert E.; Mark, Eugene J.; McNeely, William F.; McNeely, Betty U.; Rosenfield, Cathy G.; Kaplan, Mark A. (June 1994). "Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 24-1994. A two-year-old boy with thrombocytopenia, leukocytosis, and hepatosplenomegaly". N. Engl. J. Med. 330 (24): 1739–46. doi:10.1056/NEJM199406163302408. PMID 8190136.
^ Downey H, McKinlay CA. Acute Lymphadenosis Compared with Acute Lymphatic Leukemia. Arch Intern Med. 1923;32:82-112
^ "MedlinePlus Medical Encyclopedia: Mononucleosis, photomicrograph of cells". Retrieved 2009-03-07.
^ Peters CJ, Khan AS (2002). "Hantavirus pulmonary syndrome: the new American hemorrhagic fever". Clin Infect Dis 34 (9): 1224–31. doi:10.1086/339864. PMID 11941549.

External links

Review Article: The Atypical Lymphocyte- International Pediatrics Volume 18, No. 1; Michael W. Simon.
Educational Commentary: Blood Cell Identification - American Society for Clinical Pathology article.
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Journal of Veterinary Medical Science advpub(0), 1108240613, 2011
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Fatal Encephalitis in a Case of Hypereosinophilic Syndrome: MRI and Autopsy Findings

Kobayashi Zen,Tsuchiya Kuniaki,Komachi Hiroshi,Miki Kazunori,Yokota Osamu,Arai Tetsuaki,Miake Hirotomo,Ishizu Hideki,Akiyama Haruhiko,Mizusawa Hidehiro
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… Cerebrospinal fluid examination demonstrated mononuclear pleocytosis without eosinophils or atypical cells. … Histopathologically, there was infiltration of T cells, B cells and macrophages throughout the whole brain, but eosinophils or atypical cells were absent. …
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