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(medicine) the invasion of the body by pathogenic microorganisms and their multiplication which can lead to tissue damage and disease
(phonetics) the alteration of a speech sound under the influence of a neighboring sound
the pathological state resulting from the invasion of the body by pathogenic microorganisms
(international law) illegality that taints or contaminates a ship or cargo rendering it liable to seizure
moral corruption or contamination; "ambitious men are led astray by an infection that is almost unavoidable"
an incident in which an infectious disease is transmitted (同)contagion, transmission
a large heterogeneous group of RNA viruses divisible into groups on the basis of the virions; they have been recovered from arthropods, bats, and rodents; most are borne by arthropods; they are linked by the epidemiologic concept of transmission between vertebrate hosts by arthropod vectors (mosquitoes, ticks, sandflies, midges, etc.) that feed on blood; they can cause mild fevers, hepatitis, hemorrhagic fever, and encephalitis (同)arborvirus

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〈U〉(病気の)伝染;感染 / 〈C〉伝染病

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/09/20 17:58:25」(JST)

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Arbovirus is a term used to refer to a group of viruses that are transmitted by arthropod vectors. The word arbovirus is an acronym (ARthropod-BOrne virus).^[1] Symptoms of arbovirus infection generally occur 3–15 days after exposure to the virus and last 3 or 4 days. The most common clinical features of infection are fever, headache and malaise, but encephalitis and hemorrhagic fever may also occur.^[2] The word tibovirus (TIck-BOrne virus) is sometimes used to describe viruses transmitted by ticks, a superorder within the arthropods.^[3]

History

Year	Event
1800s	Dengue fever epidemics occur globally
1898-1914	First large scale effort to prevent arbovirus infection takes place in Florida, Havana and the Canal Zone
1901	First arbovirus, the Yellow fever virus, is discovered
1906	Dengue fever transmission is discovered
1936	Tick-borne encephalitis virus is discovered
1937	Yellow fever vaccine is invented
1937	West Nile virus is discovered
1950s	Japanese encephalitis vaccines are invented
1980s	Insecticide treated mosquito nets are developed
1999	West Nile virus reaches Western Hemisphere
Late 1900s	Dengue fever spreads globally

Arboviruses have existed throughout human history, but were not known to exist until fairly recently. The connection between arthropods and disease was not postulated until 1881 when Cuban doctor and scientist Carlos Finlay proposed that Yellow fever may be transmitted by mosquitoes instead of human contact,^[4] a reality that was verified by Major Walter Reed in 1901.^[5] The primary vector, Aedes aegypti, had spread globally from the 15th to the 19th centuries as a result of globalization and the slave trade.^[6] This geographic spreading caused Dengue fever epidemics throughout the 18th century,^[7] and later, in 1906, transmission by the Aedes mosquitoes was confirmed, making Yellow fever and Dengue fever the first two diseases known to be caused by viruses.^[8] The discovery of the West Nile virus came in 1937,^[9] and has since been found in Culex populations^[10] and causing epidemics throughout Africa, the Middle East and Europe. In 1999, the virus was introduced into the Western Hemisphere, sparking a series of epidemics.^[11] During the latter half of the 20th century, Dengue fever reemerged as a global disease, with the virus spreading geographically due to urbanization, population growth, increased international travel and global warming,^[12] and continues to cause at least 50 million infections per year, making Dengue fever the most common and clinically important arboviral disease.^[13]^[14]

Yellow fever, alongside malaria, was a major obstacle in the construction of the Panama Canal. French supervision of the project in the 1880s was unsuccessful because of these diseases, forcing the abandonment of the project in 1889.^[15] During the American effort to construct the canal in the early 1900s, William C. Gorgas, the Chief Sanitary Officer of Havana, was tasked with overseeing the health of the workers. He had past success in eradicating the disease in Florida and Havana by reducing mosquito populations through draining nearby pools of water, cutting grass, applying oil to the edges of ponds and swamps to kill larvae, and capturing adult mosquitoes that remained indoors during the daytime.^[16] Joseph Augustin LePrince, the Chief Sanitary Inspector of the Canal Zone, invented the first commercial larvicide, a mixture of carbolic acid, resin and caustic soda, to be used throughout the Canal Zone.^[17] The combined implementation of these sanitation measures led to a dramatic decline in the number of workers dying and the eventual eradication of Yellow fever in the Canal Zone as well as the containment of malaria during the 10-year construction period. Because of the success of these methods at preventing disease, they were adopted and improved upon in other regions of the world.^[15]^[18]

Transmission

Many female mosquitoes, like those of Aedes albopictus, require a vertebrate blood meal in order for their eggs to develop.^[19]

Arboviruses maintain themselves in nature by going through a cycle between a host, an organism that carries the virus, and a vector, an organism that carries and transmits the virus to other organisms.^[20] For arboviruses, vectors are commonly mosquitoes, ticks, sandflies^[21] and other arthropods that consume the blood of vertebrates for nutritious or developmental purposes.^[22] Vertebrates which have their blood consumed act as the hosts, with each vector generally having an affinity for the blood of specific species, making those species the hosts.^[23]

Transmission between the vector and the host occurs when the vector feeds on the blood of the vertebrate, wherein the virus that has established an infection in the salivary glands of the vector comes into contact with the host's blood.^[24]^[25] While the virus is inside the host, it undergoes a process called amplification, where the virus replicates at sufficient levels to induce viremia, a condition in which there are large numbers of viruses present in the blood.^[26] The abundance of viruses in the host's blood allows the host to transmit the virus to other organisms if its blood is consumed by them. When uninfected vectors become infected from feeding, they are then capable of transmitting the virus to uninfected hosts, resuming amplification of virus populations. If viremia is not achieved in a vertebrate, the species can be called a "dead-end host", as the virus cannot be transmitted back to the vector.^[27]

A flowchart showing the West Nile virus transmission cycle.

An example of this vector-host relationship can be observed in the transmission of the West Nile virus. Female mosquitoes of the genus Culex prefer to consume the blood of Passerine birds, making them the hosts of the virus.^[28] When these birds are infected, the virus amplifies, potentially infecting multiple mosquitoes that feed on its blood.^[26] These infected mosquitoes may go on to further transmit the virus to more birds. If the mosquito is unable to find its preferred food source, it will choose another. Human blood is sometimes consumed, but since the West Nile virus does not replicate that well in mammals, humans are considered a dead-end host.^[27]^[29]

In humans

Person-to-person transmission of arboviruses is not common, but can occur. Blood transfusions, organ transplantation and the use of blood products can transmit arboviruses if the virus is present in the donor's blood or organs.^[30]^[31]^[32] Because of this, blood and organs are often screened for viruses before being administered.^[32]^[33] Rarely, vertical transmission, or mother-to-child transmission, has been observed in infected pregnant^[34] and breastfeeding women.^[35] Exposure to used needles may also transmit arboviruses if they have been used by an infected person or animal.^[36] This puts intravenous drug users and healthcare workers at risk for infection in regions where the arbovirus may be spreading in human populations.^[32]^[34]

Structure and genome

The majority of the arboviruses are spherical in shape although a few are rod-shaped. They are 17-150 nm in diameter and most have an RNA genome (the single exception is African swine fever virus, which has a DNA genome).

Classification

In the past, arboviruses were organized into one of four groups: A, B, C and D. Group A denoted members of the genus Alphavirus,^[37]^[38] Group B were members of the genus Flavivirus,^[39] and Group C remains as the Group C serogroup of the genus Orthobunyavirus.^[40] Group D was renamed in the mid-1950s to the Guama group and is currently the Guama serogroup in the genus Orthobunyavirus.^[41] This renaming of the group was because the number of groups would eventually exceed the length of the alphabet. Since then, the organization of arboviruses into these groups has fallen out of usage as the standard biological classification system became more preferred for classifying viruses.^[41] With the exception of the African swine fever virus, which belongs to the Asfarviridae family of viruses, all major clinically important arboviruses belong to one of the following four families:

Family Bunyaviridae
- Genus Nairovirus
  - Crimean–Congo hemorrhagic fever virus (CCHF)
- Genus Orthobunyavirus
  - Bunyamwera virus
  - California encephalitis virus
  - La Crosse encephalitis virus (LACV)
- Genus Phlebovirus
  - Rift Valley fever virus (RVFV)
  - Toscana virus (TOSV)
  - Heartland virus
Family Flaviviridae
- Genus Flavivirus
  - Tick-borne viruses
    - Mammalian tick-borne virus group
      - Kyasanur forest disease virus (KFDV)
      - Tick-borne encephalitis virus (TBEV)
  - Mosquito-borne viruses
    - Dengue virus group
      - Dengue virus (DENV)
    - Japanese encephalitis virus group
      - Japanese encephalitis virus (JEV)
      - Murray Valley encephalitis virus (MVEV)
      - St. Louis encephalitis virus (SLEV)
      - West Nile virus (WNV)
    - Yellow fever virus group
      - Yellow fever virus (YFV)
Family Reoviridae
- Subfamily Sedoreovirinae
  - Genus Orbivirus
    - African horse sickness virus (AHSV)
    - Bluetongue disease virus (BTV)
    - Equine encephalosis virus (EEV)
  - Genus Seadornavirus
    - Banna virus (BAV)
- Subfamily Spinareovirinae
  - Genus Coltivirus
    - Colorado tick fever virus (CTFV)
Family Togaviridae
- Genus Alphavirus
  - Eastern equine encephalitis virus (EEE)
  - Ross River virus (RRV)
  - Venezuelan equine encephalitis virus (VEE)
  - Western equine encephalitis virus (WEE)
  - Chikungunya virus (CHIKV)

Signs and symptoms

The incubation period - the time between when infection occurs and when symptoms appear - varies from virus to virus, but is usually limited between 2 and 15 days for arboviruses.^[42] The majority of infections, however, are asymptomatic.^[43] Among cases in which symptoms do appear, symptoms tend to be non-specific, resembling a flu-like illness, and are not indicative of a specific causative agent. These symptoms include fever, headache, malaise, rash and fatigue. Rarely, vomiting and hemorrhagic fever may occur. The central nervous system can also be affected by infection, as encephalitis and meningitis are sometimes observed.^[44] Prognosis is good for most people, but is poor in those who develop severe symptoms, with up to a 20% mortality rate in this population depending on the virus. The very young, elderly, pregnant women and people with immune deficiencies are more likely to develop severe symptoms.

Arbovirus	Disease(s)	Incubation period	Symptoms	Duration of symptoms	Complications	Case fatality rate	Vector(s)	Primary host(s)	Geographic distribution	Does infection provide lifelong immunity?
Dengue virus	Dengue fever	3–14 days	Asymptomatic in most cases; fever, headache, rash, muscle and joint pains	7–10 days	Shock, internal bleeding and organ damage	<1% with treatment, 1-5% without; about 25% in severe cases	Aedes mosquitoes, especially Aedes aegypti	Humans	Near the equator globally	Varies^{[note 1]}
Japanese encephalitis virus	Japanese encephalitis	5–15 days	Asymptomatic in most cases; fever, headache, fatigue, nausea and vomiting		Encephalitis, seizures, paralysis, coma and long-term brain damage	20-30% in encephalitis cases	Culex mosquitoes, especially Culex tritaeniorhynchus	Domestic pigs and wading birds	Southeast and East Asia	Yes
Rift Valley fever virus	Rift Valley fever	2–6 days	Fever, headache, myalgia and liver abnormalities	4–7 days	Hemorrhagic fever, meningoencephalitis	1% in humans; in pregnant livestock, 100% fatality rate for fetuses	Culex tritaeniorhynchus and Aedes vexans	Micropteropus pusillus and Hipposideros abae	Eastern, Southern and Western Africa	Yes
Tick-borne encephalitis virus	Tick-borne encephalitis	7–14 days	Fever, headache, muscle pain, nausea, vomiting, meningitis and encephalitis		Paralysis and long-term brain damage	1-2%	Ixodes scapularis, Ixodes ricinus and Ixodes persulcatus	Small rodents	Eastern Europe and Southern Russia	Yes
West Nile virus	West Nile fever, encephalitis	2–15 days	Asymptomatic in most cases; fever, headache, fatigue, nausea, vomiting, rash	3–6 days	Swollen lymph nodes, meningitis, encephalitis, acute flaccid paralysis	3-15% in severe cases	Culex mosquitoes	Passerine birds	North America, Europe, West and Central Asia, Oceania and Africa	Yes
Yellow fever virus	Yellow fever	3–6 days	Fever, headache, back pain, loss of appetite, nausea and vomiting	3–4 days	Jaundice, liver damage, gastrointestinal bleeding, recurring fever	3% in general; 20% in cases with severe complications	Aedes mosquitoes, especially Aedes aegypti	Primates	Tropical and subtropical regions of South America and Africa	Yes

^ Infection provides lifelong immunity to the specific serotype causing illness, but temporary immunity to other serotypes.

Diagnosis

Preliminary diagnosis of arbovirus infection is usually based on clinical presentations of symptoms, places and dates of travel, activities and epidemiological history of the location where infection occurred.^[45] Definitive diagnosis is typically made in a laboratory by employing some combination of blood tests, particularly immunologic, serologic and/or virologic techniques such as ELISA,^[45]^[46] complement fixation,^[46] polymerase chain reaction,^[46]^[47] neutralization test^[48] and hemagglutination-inhibition test.^[49]

Prevention

Vector control measures, especially mosquito control, are essential to reducing the transmission of disease by arboviruses. Habitat control involves draining swamps and removal of other pools of stagnant water (such as old tires, large outdoor potted plants, empty cans, etc.) that often serve as breeding grounds for mosquitoes. Insecticides can be applied in rural and urban areas, inside houses and other buildings or in outdoor environments. They are often quite effective for controlling arthropod populations, though use of some of these chemicals is controversial, and some organophosphates and organochlorides (such as DDT) have been banned in many countries. Infertile male mosquitoes have been introduced in some areas in order to reduce the breeding rate of relevant mosquito species. Larvicides are also used worldwide in mosquito abatement programs. Temefos is a common mosquito larvicide.^[50]

Tent made of mosquito netting

People can also reduce the risk of getting bitten by arthropods by employing personal protective measures such as sleeping under mosquito nets, wearing protective clothing, applying insect repellents such as permethrin and DEET to clothing and exposed skin, and (where possible) avoiding areas known to harbor high arthropod populations. Arboviral encephalitis can be prevented in two major ways: personal protective measures and public health measures to reduce the population of infected mosquitoes. Personal measures include reducing time outdoors particularly in early evening hours, wearing long pants and long sleeved shirts and applying mosquito repellent to exposed skin areas. Public health measures often require spraying of insecticides to kill juvenile (larvae) and adult mosquitoes.^[51]

Vaccination

Vaccines are available for the following arboviral diseases:

Japanese encephalitis^[52]
Yellow fever^[53]

Vaccines are in development for the following arboviral diseases:

Dengue fever^[54]
Eastern Equine encephalitis^[55]
West Nile^[56]

Treatment

Because the arboviral encephalitides are viral diseases, antibiotics are not an effective form of treatment and no effective antiviral drugs have yet been discovered. Treatment is supportive, attempting to deal with problems such as swelling of the brain, loss of the automatic breathing activity of the brain and other treatable complications like bacterial pneumonia.^[1]

Aspirin and ibuprofen should not be taken in cases of dengue fever as it could increase the risk of bleeding and cause Dengue Shock Syndrome.^[57]

Epidemiology

References

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External links

Beran, G. W., ed. (1994). Handbook of Zoonoses. CRC Press. ISBN 9780849332067.

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1. 節足動物媒介性脳炎arthropod borne encephalitides [show details]
2. オーストラリア、ニュージーランド、南西太平洋（オセアニア）への旅行者における健康被害の可能性potential health hazards in travelers to australia new zealand and the southwestern pacific oceania [show details]
3. チクングニア熱：疫学、臨床症状、診断chikungunya fever epidemiology clinical manifestations and diagnosis [show details]
4. 成人におけるウイルス性脳炎viral encephalitis in adults [show details]
…Africa, Asia, and Europe, and then spread rapidly across the country. The incidence of other arthropod-borne viruses (arboviruses) varies significantly based upon geographic region. As an example, St. Louis …
5. ウエストナイルウイルス感染症の臨床症状と診断clinical manifestations and diagnosis of west nile virus infection [show details]

English Journal

Prevalence and identification of arthropod-transmitted viruses in Kassala state, Eastern Sudan.

Mohamed N, Magzoub M, Mohamed REH, Aleanizy FS, Alqahtani FY, Nour BYM, Alkarsany MMS.
The Libyan journal of medicine. 2019 Dec;14(1)1564511.
Vector-borne diseases are responsible for more than 20% of the infectious diseases worldwide. The prevalence of arboviruses transmit diseases to humans in Sudan has not been investigated. Mosquito-borne viral diseases increase globally incidence, including the Sudan. Frequent unknown fever outbreaks
PMID 30716013

The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus, and HIV infections.

Mehrbod P, Ande SR, Alizadeh J, Rahimizadeh S, Shariati A, Malek H, Hashemi M, Glover KKM, Sher AA, Coombs KM, Ghavami S.
Virulence. 2019 Dec;10(1)376-413.
Virus infection induces different cellular responses in infected cells. These include cellular stress responses like autophagy and unfolded protein response (UPR). Both autophagy and UPR are connected to programed cell death I (apoptosis) in chronic stress conditions to regulate cellular homeostasis
PMID 30966844

Dengue Outbreak during Ongoing Civil War, Taiz, Yemen.

Alghazali KA, Teoh BT, Loong SK, Sam SS, Che-Mat-Seri NA, Samsudin NI, Yaacob CN, Azizan NS, Oo A, Baharudin NA, Tan KK, Abd-Jamil J, Nor'e SS, Khor CS, Johari J, Mahdy MAK, AbuBakar S.
Emerging infectious diseases. 2019 Jul;25(7).
We identified dengue in ≈51% of patients given a clinical diagnosis of suspected dengue in Taiz, Yemen, during 2016. The cosmopolitan genotype of dengue virus type 2 was most common; viruses appeared to have originated in Saudi Arabia. Damage to public health infrastructure during ongoing civil wa
PMID 30924766

Japanese Journal

鹿児島県内の飼養牛及び先天異常子牛におけるシャモンダウイルス感染状況の遡及調査 (日本獣医師会雑誌(日獣会誌)) -- (産業動物臨床・家畜衛生関連部門)

日本獣医師会雑誌 = Journal of the Japan Veterinary Medical Association 70(11), 729-734, 2017-11
NAID 40021386281

Development and evaluation of a rapid molecular diagnostic test for Zika virus infection by reverse transcription loop-mediated isothermal amplification

Scientific Reports 7, 13503, 2017-10-18
NAID 120006363415

鹿児島県内の飼養牛及び先天異常子牛におけるシャモンダウイルス感染状況の遡及調査

日本獣医師会雑誌 70(11), 729-734, 2017
NAID 130006258885

Related Pictures

★リンクテーブル★

リンク元	「アルボウイルス感染」「アルボウイルス感染症」
関連記事	「infection」

「アルボウイルス感染」

Arbovirus infection
	Classification and external resources
	Tissue infected with the Rift Valley fever virus
MeSH	D001102

　　[★]

英: arbovirus infection
関: アルボウイルス感染症

「アルボウイルス感染症」

　　[★]

英: arbovirus infection
関: アルボウイルス感染

「infection」

　　[★]

n.

感染、伝染、感染症

関: contagion、infect、infectious disease、infestation、transmission、transmit

[45] Infection provides lifelong immunity to the specific serotype causing illness, but temporary immunity to other serotypes.

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[58] ttp://www.who.int/denguecontrol/human/en/

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案内

arbovirus infection