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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/11/30 02:06:57」(JST)

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Arabinofuranosylcytosine triphosphate is a nucleotide that inhibits the synthesis of DNA by acting as an antimetabolic agent against deoxycytidine (a component of DNA). It is the biologically active form of cytarabine.^[1]

References

^ ^a ^b Ara-CTP - Compound Summary, PubChem.

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1. 運動生理学exercise physiology [show details]
…oxygen binding protein myoglobin, a high content of oxidative enzymes for producing adenosine triphosphate (ATP), and a high density of mitochondria . These fibers tend to be fatigue resistant and are …
2. 術後に生じる電解質異常の概要overview of postoperative electrolyte abnormalities [show details]
…commonly observed as extracellular phosphate is rapidly taken into the cells to generate adenosine triphosphate (ATP). Hypokalemia and hypocalcemia are also commonly observed. Malnourished patients should…
3. 拡張能障害の細胞学的機序cellular mechanisms of diastolic dysfunction [show details]
…myocyte relaxation include: Ischemia and/or hypoxia; Cellular calcium overload and/or adenosine triphosphate (ATP) depletion; Certain cardiovascular drugs, eg, digitalis; The hypertrophy process itself which …
4. ファムシクロビル：概要famciclovir an overview [show details]
…monophosphorylated by virally-encoded thymidine kinase and subsequently converted to a triphosphate by cellular enzymes. Penciclovir triphosphate preferentially inhibits the DNA polymerase of susceptible viruses; at clinically …
5. 筋肉におけるエネルギー代謝energy metabolism in muscle [show details]
…glycolysis, and the creatine kinase reaction, in which phosphocreatine is converted to adenosine triphosphate (ATP), are the primary sources of energy . With submaximal exercise, the type of substrate used …

English Journal

Thiosemicarbazone derivatives, thiazolyl hydrazones, effectively inhibit leukemic tumor cell growth: Down-regulation of ribonucleotide reductase activity and synergism with arabinofuranosylcytosine.

Graser-Loescher G1, Schoenhuber A1, Ciglenec C1, Eberl S2, Krupitza G3, Mader RM4, Jadav SS5, Jayaprakash V5, Fritzer-Szekeres M1, Szekeres T1, Saiko P6.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.Food Chem Toxicol.2017 Oct;108(Pt A):53-62. doi: 10.1016/j.fct.2017.07.029. Epub 2017 Jul 14.
PMID 28716444

[A Case of Intrathecal Infusion of Methotrexate and Ara-C for a Patient with Meningitis Due to Recurrent Gastric Cancer].

Oiwa T1, Kurumiya Y, Mizuno K, Sekoguchi E, Kobayashi S, Kawai K, Kiriyama M, Tominaga K, Torii N, Nakashima Y, Mori M, Ikeda S, Watanabe H.
Gan to kagaku ryoho. Cancer & chemotherapy.Gan To Kagaku Ryoho.2017 May;44(5):413-415.
PMID 28536338

Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies.

Herold N1, Rudd SG2, Ljungblad L1, Sanjiv K2, Myrberg IH1, Paulin CB2, Heshmati Y3, Hagenkort A2, Kutzner J4, Page BD2, Calderón-Montaño JM2, Loseva O2, Jemth AS2, Bulli L4, Axelsson H2,5, Tesi B1, Valerie NC2, Höglund A2, Bladh J1, Wiita E2, Sundin M6,7, Uhlin M8,9, Rassidakis G8, Heyman M1, Tamm KP8, Warpman-Berglund U2, Walfridsson J3, Lehmann S3,10, Grandér D8, Lundbäck T2,5, Kogner P1, Henter JI1, Helleday T2, Schaller T4.
Nature medicine.Nat Med.2017 Feb;23(2):256-263. doi: 10.1038/nm.4265. Epub 2017 Jan 9.
PMID 28067901

Japanese Journal

Development of a sensitive and selective LC/MS/MS method for the simultaneous determination of intracellular 1-beta-D-arabinofuranosylcytosine triphosphate (araCTP), cytidine triphosphate (CTP) and deoxycytidine triphosphate (dCTP) in a human follicular lymphoma cell line

CRAUSTE Celine,LEFEBVRE Isabelle,HOVANEISSIAN Michael,PUY Jean Yves,ROY Beatrice,PEYROTTES Suzanne,COHEN Sabine,GUITTON Jerome,DUMONTET Charles,PERIGAUD Christian
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 877(14), 1417-1425, 2009-05-15
NAID 10028017352

Close correlation of 1-beta-D-arabinofuranosylcytosine 5'-triphosphate, an intracellular active metabolite, to the therapeutic efficacy of N(4)-behenoyl-1-beta-D-arabinofuranosylcytosine therapy for acute myelogenous leukemia.

Yamauchi Takahiro,Kawai Yasukazu,Goto Nobuyuki,Kishi Shinji,Imamura Shin,Yoshida Akira,Urasaki Yoshimasa,Fukushima Toshihiro,Iwasaki Hiromichi,Tsutani Hiroshi,Masada Mikio,Ueda Takanori
Japanese journal of cancer research : gann 92(9), 975-982, 2001-09-30
… N(4)-Behenoyl-1-beta-D-arabinofuranosylcytosine (BHAC), a prodrug of 1-beta-D-arabinofuranosylcytosine, is used effectively for the treatment of leukemia in Japan. … BHAC therapy may be more effective if it is delivered in conjunction with monitoring of 1-beta-D-arabinofuranosylcytosine 5'-triphosphate (ara-CTP), the intracellular active metabolite of ara-C derived from BHAC. …
NAID 120000807741

Monitoring of intracellular 1-beta-D-arabinofuranosylcytosine 5'-triphosphate in 1-beta-D-arabinofuranosylcytosine therapy at low and conventional doses.

Yamauchi Takahiro,Kawai Yasukazu,Kishi Shinji,Goto Nobuyuki,Urasaki Yoshimasa,Imamura Shin,Fukushima Toshihiro,Yoshida Akira,Iwasaki Hiromichi,Tsutani Hiroshi,Masada Mikio,Ueda Takanori
Japanese journal of cancer research : gann 92(5), 546-553, 2001-05-31
… 1-beta-D-Arabinofuranosylcytosine (ara-C) is used empirically at a low, conventional, or high dose. … Ara-C therapy may be optimal if it is directed by the clinical pharmacokinetics of the intracellular active metabolite of ara-C, 1-beta-D-arabinofuranosylcytosine 5'-triphosphate (ara-CTP). …
NAID 120000807662

Related Pictures

c-Abl-independent p73 stabilization during gemcitabine- or 4′-thio-β-d Cytarabine InjectionFor Intravenous, Intrathecal and Subcutaneous Use Only The Role of Cytidine Deaminase and GATA1 Mutations in the Increased Cytosine (PDF) Saturation of 1-β-d-Arabinofuranosylcytosine 5′-Triphosphate Accumulation in Arabinofuranosylcytosine Triphosphate; Ara-CTP; Arabinosylcytosine Triphosphate

★リンクテーブル★

リンク元	「アラビノフラノシルシトシン三リン酸」
関連記事	「arabinofuranosylcytosine」「triphosphate」

「アラビノフラノシルシトシン三リン酸」

Arabinofuranosylcytosine triphosphate^[1]
Names
	Other names Ara-CTP, Cytarabine triphosphate,; Cytosine arabinoside triphosphate
Identifiers
CAS Number	13191-15-6
3D model (Jmol)	Interactive image
ChemSpider	29784777
MeSH	Arabinofuranosylcytosine+triphosphate
PubChem	25774
	InChI InChI=1S/C10H18N3O13P3/c11-6-1-2-13(10(16)12-6)9-8(15)7(14)5(25-9)3-24-29(22,23)26-28(20,21)4-27(17,18)19/h1-2,5,7-9,14-15H,3-4H2,(H,20,21)(H,22,23)(H2,11,12,16)(H2,17,18,19)/t5-,7-,8+,9-/m1/s1 Key: PEZFHAVVQBLXDV-BUJSFMDZSA-N ; InChI=1/C10H18N3O13P3/c11-6-1-2-13(10(16)12-6)9-8(15)7(14)5(25-9)3-24-29(22,23)26-28(20,21)4-27(17,18)19/h1-2,5,7-9,14-15H,3-4H2,(H,20,21)(H,22,23)(H2,11,12,16)(H2,17,18,19)/t5-,7-,8+,9-/m1/s1 Key: PEZFHAVVQBLXDV-BUJSFMDZBE ;
	SMILES c1cn(c(=O)nc1N)[C@H]2[C@H]([C@@H]([C@H](O2)COP(=O)(O)OP(=O)(CP(=O)(O)O)O)O)O ;
Properties
Chemical formula	C9H16N3O14P3
Molar mass	483.156323
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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	Infobox references