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The potential of apolipoprotein E4 to act as a substrate for primary cultures of hippocampal neurons.

Kim KM, Vicenty J, Palmore GT.SourceSchool of Engineering, Brown University, Providence, RI 02912, USA; Center for Biomedical Engineering, Brown University, Providence, RI 02912, USA.
Biomaterials.Biomaterials.2013 Apr;34(11):2694-700. doi: 10.1016/j.biomaterials.2013.01.012. Epub 2013 Jan 23.
The E4 isoform of apolipoprotein (apoE4) is known to be a major risk factor for Alzheimer's Disease (AD). Previous in vitro studies have shown apoE4 to have a negative effect on neuronal outgrowth when incubated with lipids. The effect of apoE4 itself on the development of neurons from the central
PMID 23352042

Default mode network activity and white matter integrity in healthy middle-aged ApoE4 carriers.

Patel KT, Stevens MC, Pearlson GD, Winkler AM, Hawkins KA, Skudlarski P, Bauer LO.SourceOlin Neuropsychiatry Research Center, Institute of Living at Hartford Hospital, 200 Retreat Avenue, Hartford, CT, 06106, USA, Kpancholi@harthosp.org.
Brain imaging and behavior.Brain Imaging Behav.2013 Mar;7(1):60-7. doi: 10.1007/s11682-012-9187-y.
Alzheimer's disease (AD) is most commonly detected during old age, but the underlying neuropathologic changes likely appear decades earlier, especially among patients possessing genetic risk factors, such as the isoform E4 of the apolipoprotein E (ApoE4). In this study, we used magnetic resonance im
PMID 23011382

A silent mutation of Niemann-Pick C1-like 1 and apolipoprotein E4 modulate cholesterol absorption in primary hyperlipidemias.

Lupattelli G, Pisciotta L, De Vuono S, Siepi D, Bellocchio A, Melis F, Bertolini S, Pirro M, Mannarino E.SourceDepartment of Clinical and Experimental Medicine, Internal Medicine, Angiology and Atherosclerosis, "Santa Maria della Misericordia" Hospital, Piazzale Menghini, Sant'Andrea delle Fratte, University of Perugia, Perugia, 06132, Italy. Electronic address: glupa@unipg.it.
Journal of clinical lipidology.J Clin Lipidol.2013 Mar;7(2):147-52. doi: 10.1016/j.jacl.2012.12.003. Epub 2012 Dec 20.
OBJECTIVE: To investigate the influence of the silent mutation c.816C > G (L272) of Niemann-Pick C1-like 1 (NPC1L1) and of apolipoprotein (APO) E alleles on cholesterol absorption markers, sitosterol and campesterol, in 87 patients with primary hyperlipidemias.METHODS: In all subjects genotyped
PMID 23415434

Polymorphisms of the ApoE (Apolipoprotein E) Gene and Their Influence on Dyslipidemia in HIV-1-Infected Individuals

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Japanese Journal of Infectious Diseases 68(1), 5-12, 2015
… The purpose of this retrospective case-control study was to investigate the frequency of Apolipoprotein E (ApoE) polymorphisms and their influence on antiretroviral therapy (ART)-induced lipodystrophy or dyslipidemia in HIV-infected Thai patients. …
NAID 130004757124

The distribution of Apolipoprotein E gene polymorphism and their influences in dyslipidemias in HIV-1 infections

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Japanese Journal of Infectious Diseases, 2014
… The purpose of this study was to investigate the frequency of ApoE (Apolipoprotein E) polymorphisms and their influence on antiretroviral therapy (ART) induced lipodystrophy/dyslipidemia in HIV-infected Thai patients. … Among 85 patients ApoE genotypes frequencies were 2.35% (n=2) for E2/E2, 20% (n=17) for E2/E3, 9.41% (n=8) for E2/E4, 36.47% (n=31) for E3/E3, 30.59% (n=26) for E3/E4 and 1.18% (n=1) for E4/E4. …
NAID 130004716731