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- 1. オンコセルカ症 onchocerciasis
- 2. アミロイド疾患の遺伝的要因 genetic factors in the amyloid diseases
English Journal
- Clinical features and genetic analysis of three patients with severe hypertriglyceridaemia.
- Hooper AJ1, Kurtkoti J, Hamilton-Craig I, Burnett JR.Author information 1Department of Clinical Biochemistry, Path West Laboratory Medicine WA, Royal Perth Hospital, Perth, Australia.AbstractHypertriglyceridaemia is a common biochemical abnormality that can be due to primary causes or, more commonly, secondary causes. Moderate hypertriglyceridaemia is a risk factor for cardiovascular disease and can develop into severe hypertriglyceridaemia which is a risk factor for acute pancreatitis. Familial chylomicronaemia is a rare autosomal recessive disorder, usually diagnosed in childhood and is characterized by marked hypertriglyceridaemia and biochemical deficiency of lipoprotein lipase (LPL), apolipoprotein (apo) C-II, homozygous (or compound heterozygous) gene mutations in LPL or more rarely, APOC2. Recently, loss-of-function mutations in the APOA5 gene have been reported in patients with severe hypertriglyceridaemia in whom LPL or APOC2 mutations were not found. We describe the clinical features and genetic analysis of three patients with severe hypertriglyceridaemia including novel mutations LPL c.464T>C (p.Leu155Pro) and APOA5 c.823C>T (p.Gln275*).
- Annals of clinical biochemistry.Ann Clin Biochem.2014 Mar 3. [Epub ahead of print]
- Hypertriglyceridaemia is a common biochemical abnormality that can be due to primary causes or, more commonly, secondary causes. Moderate hypertriglyceridaemia is a risk factor for cardiovascular disease and can develop into severe hypertriglyceridaemia which is a risk factor for acute pancreatitis.
- PMID 24591733
- Glycomic Analysis of High Density Lipoprotein Shows a Highly Sialylated Particle.
- Huang J1, Lee H, Zivkovic AM, Smilowitz JT, Rivera N, German JB, Lebrilla CB.Author information 1Department of Chemistry, ‡Department of Food Science and Technology, and §Foods for Health Institute, University of California , Davis, California 95616, United States.AbstractMany of the functional proteins and lipids in high density lipoprotein (HDL) particles are potentially glycosylated, yet very little is known about the glycoconjugates of HDL. In this study, HDL was isolated from plasma by sequential micro-ultracentrifugation, followed by glycoprotein and glycolipid analysis. N-Glycans, glycopeptides, and gangliosides were extracted and purified followed by analysis with nano-HPLC Chip quadrupole time of flight mass spectrometry and MS/MS. HDL particles were found to be highly sialylated. Most of the N-glycans (∼90%) from HDL glycoproteins were sialylated with one or two neuraminic acids (Neu5Ac). The most abundant N-glycan was a biantennary complex type glycan with two sialic acids (Hexose5HexNAc4Neu5Ac2) and was found in multiple glycoproteins using site-specific glycosylation analysis. The observed O-glycans were all sialylated, and most contained a core 1 structure with two Neu5Acs, including those that were associated with apolipoprotein CIII (ApoC-III) and fetuin A. GM3 (monosialoganglioside, NeuAc2-3Gal1-4Glc-Cer) and GD3 (disialoganglioside, NeuAc2-8NeuAc2-3Gal1-4Glc-Cer) were the major gangliosides in HDL. A 60% GM3 and 40% GD3 distribution was observed. Both GM3 and GD3 were composed of heterogeneous ceramide lipid tails, including d18:1/16:0 and d18:1/23:0. This report describes for the first time a glycomic approach for analyzing HDL, highlighting that HDL are highly sialylated particles.
- Journal of proteome research.J Proteome Res.2014 Jan 21. [Epub ahead of print]
- Many of the functional proteins and lipids in high density lipoprotein (HDL) particles are potentially glycosylated, yet very little is known about the glycoconjugates of HDL. In this study, HDL was isolated from plasma by sequential micro-ultracentrifugation, followed by glycoprotein and glycolipid
- PMID 24417605
- ApoC-III and visceral adipose tissue contribute to paradoxically normal triglyceride levels in insulin-resistant African-American women.
- Sumner AE1, Furtado JD, Courville AB, Ricks M, Younger-Coleman N, Tulloch-Reid MK, Sacks FM.Author information 1Diabetes, Endocrinology and Obesity Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA. AnneS@intra.niddk.nih.gov.AbstractBACKGROUND: African-Americans are more insulin-resistant than whites but have lower triglyceride (TG) concentrations. The metabolic basis for this is unknown. Our goal was to determine in a cross-sectional study the effect of insulin resistance, visceral adipose tissue (VAT) and the apolipoproteins, B, C-III and E, on race differences in TG content of very low density lipoproteins (VLDL).
- Nutrition & metabolism.Nutr Metab (Lond).2013 Dec 23;10(1):73. doi: 10.1186/1743-7075-10-73.
- BACKGROUND: African-Americans are more insulin-resistant than whites but have lower triglyceride (TG) concentrations. The metabolic basis for this is unknown. Our goal was to determine in a cross-sectional study the effect of insulin resistance, visceral adipose tissue (VAT) and the apolipoproteins,
- PMID 24365086
Japanese Journal
- Association of common variants in TOMM40/APOE/APOC1 region with human longevity in a Chinese population
- Journal of human genetics 61(4), 323-328, 2016-04
- NAID 40020802855
- Effects of the difference in similarity measures on the comparison of ligand-binding pockets using a reduced vector representation of pockets
- Biophysics and Physicobiology 13(0), 139-147, 2016
- NAID 130005165372
- Renal Insufficiency without Albuminuria is Associated with Peripheral Artery Atherosclerosis and Lipid Metabolism Disorders in Patients with Type 2 Diabetes
- Journal of Atherosclerosis and Thrombosis 20(11), 790-797, 2013
- NAID 130004845417
Related Links
- APOC/アポック (表参道/パンケーキ)の店舗情報は食べログでチェック！口コミや評価、写真など、ユーザーによるリアルな情報が満載です！地図や料理メニューなどの詳細情報も充実。
- APOC（アポック）はパンケーキ専門店です。メニューはパンケーキセット。そして、だれにでもおいしく作れるパンケーキミックスを販売しています。2000年から作り続けているパンケーキミックスは、添加物、保存料、香料を使わない ...
Related Pictures
★リンクテーブル★
| リンク元 | 「アポリポ蛋白C」「アポリポタンパク質C」「apolipoprotein C」「アポC」 |
| 関連記事 | 「apo」 |
「アポリポ蛋白C」
「アポリポタンパク質C」
「apolipoprotein C」
「アポC」
- 英
- apoC
- 関
- アポリポ蛋白C、アポリポタンパク質C