WordNet

situated at an apex
a disorder (usually of unknown origin) of the heart muscle (myocardium) (同)myocardiopathy

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頂点の,頂点(頂上)をなす / 舌先で調音する / 舌尖(ぜっせん)音(舌先で調音する[t][d][l]など)

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1. 閉塞性肥大型心筋症の種類および病態生理 types and pathophysiology of obstructive hypertrophic cardiomyopathy
2. 成人スティル病の臨床症状および診断 clinical manifestations and diagnosis of adult stills disease
3. 肥大型心筋症の自然経過 natural history of hypertrophic cardiomyopathy
4. 孤立性左室心筋緻密化障害 isolated left ventricular non compaction

English Journal

The relationship between electrocardiographic changes and CMR features in asymptomatic or mildly symptomatic patients with hypertrophic cardiomyopathy.

Chen X1, Zhao T, Lu M, Yin G, Xiangli W, Jiang S, Prasad S, Zhao S.Author information 1Department of Radiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College, Chinese Academy of Medical Sciences, 167 Beilishi Road, Xi Cheng District, Beijing, 100037, China.AbstractTo investigate the relationship between electrocardiographic (ECG) abnormalities and left ventricular (LV) segmental hypertrophy and myocardial fibrosis assessed by cardiovascular magnetic resonance (CMR) in asymptomatic or mildly symptomatic patients with hypertrophic cardiomyopathy (HCM). 118 asymptomatic or mildly symptomatic patients with HCM were examined with late gadolinium enhancement (LGE) CMR, 12-lead ECG, and echocardiography. The distribution and magnitude of LV segmental hypertrophy and LGE were assessed and analyzed in relation to ECG abnormalities. Abnormal electrocardiograms were found in 113 of 118 (95 %) patients. Negative T waves were associated with greater apical septal thickness (P = 0.009) and an increased ratio of LV septum to free wall thickness (P = 0.01). Giant negative T waves (GNT) were found in 19 patients (16 %), and were associated with apical HCM (P < 0.001), greater apical thickness (P = 0.004), and increased ratio of LV apical to basal wall thickness (P < 0.001). However, no significant association was demonstrated between GNT and apical LGE (P = 0.71). Abnormal Q waves were associated with greater basal anteroseptal thickness (P = 0.001), maximal basal thickness (P = 0.004), and more segments with extensive LGE (>75 % wall thickness involved) (P = 0.001). LV hypertrophy was related to greater LV mass (P = 0.002) and LV end diastolic volume (P = 0.002). In addition, a modest but significant correlation was observed between maximum LV wall thickness and the Romhilt-Estes score (r = 0.41, P < 0.001). GNT were associated with apical HCM and an increased ratio of LV apical to basal wall thickness. Abnormal Q waves were related to basal anteroseptal hypertrophy and segmental extensive LGE.
The international journal of cardiovascular imaging.Int J Cardiovasc Imaging.2014 Apr 11. [Epub ahead of print]
To investigate the relationship between electrocardiographic (ECG) abnormalities and left ventricular (LV) segmental hypertrophy and myocardial fibrosis assessed by cardiovascular magnetic resonance (CMR) in asymptomatic or mildly symptomatic patients with hypertrophic cardiomyopathy (HCM). 118 asym
PMID 24723003

Abnormal Cardiac Formation in Hypertrophic Cardiomyopathy - Fractal Analysis of Trabeculae and Preclinical Gene Expression.

Captur G1, Lopes L, Patel V, Li C, Bassett P, Syrris P, Sado DM, Maestrini V, Mohun TJ, McKenna WJ, Muthurangu V, Elliott PM, Moon JC.Author information 11The Heart Hospital, Division of Cardiovascular Imaging, University College London NHS Foundation Trust & UCL Institute of Cardiovascular Science, University College London, London, United Kingdom.AbstractBACKGROUND: -Mutations in genes coding for sarcomeric proteins cause hypertrophic cardiomyopathy (HCM). Subtle abnormalities of the myocardium may be present in mutation carriers without hypertrophy (G+LVH-) but are difficult to quantify. Fractal analysis has been used to define trabeculae in LV noncompaction and to identify normal racial variations. We hypothesized that trabeculae measured by fractal analysis of cardiovascular magnetic resonance (CMR) images are abnormal in G+LVH- patients providing a preclinical marker of disease in HCM.
Circulation. Cardiovascular genetics.Circ Cardiovasc Genet.2014 Apr 5. [Epub ahead of print]
BACKGROUND: -Mutations in genes coding for sarcomeric proteins cause hypertrophic cardiomyopathy (HCM). Subtle abnormalities of the myocardium may be present in mutation carriers without hypertrophy (G+LVH-) but are difficult to quantify. Fractal analysis has been used to define trabeculae in LV non
PMID 24704860

Comparison of the Prevalence, Clinical Features, and Long-term Outcomes of Midventricular Hypertrophy vs Apical Phenotype in Patients With Hypertrophic Cardiomyopathy.

Cai C1, Duan FJ2, Yang YJ1, Guo XY1, Liu YL2, Liu YQ1, Yan LR1, Xu ZM1, Zhao SH3, Hua W4, Li YS1, Fan CM5.Author information 1Key Laboratory of Clinical Trial Research in Cardiovascular Drugs, Ministry of Health, State Key Laboratory of Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.2Department of Ultrasound, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.3Department of Radiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.4The Cardiac Arrhythmia Center, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.5Key Laboratory of Clinical Trial Research in Cardiovascular Drugs, Ministry of Health, State Key Laboratory of Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Electronic address: fred_fan2004@aliyun.com.AbstractBACKGROUND: Previous studies on the association between the distribution of left ventricle hypertrophy and the clinical features of hypertrophic cardiomyopathy (HCM) have yielded unclear results. The aim of this study was to investigate the differences in the prevalence, clinical features, management strategies, and long-term outcomes between patients with midventricular hypertrophic obstructive cardiomyopathy (MVHOCM) and patients with apical HCM (ApHCM).
The Canadian journal of cardiology.Can J Cardiol.2014 Apr;30(4):441-7. doi: 10.1016/j.cjca.2013.10.005. Epub 2013 Oct 9.
BACKGROUND: Previous studies on the association between the distribution of left ventricle hypertrophy and the clinical features of hypertrophic cardiomyopathy (HCM) have yielded unclear results. The aim of this study was to investigate the differences in the prevalence, clinical features, managemen
PMID 24468417

Japanese Journal

A Surgical Case of Apical Aneurysm without Hypertrophic Cardiomyopathy

Matsuyama Katsuhiko,Nakayama Tomohiro,Hagiwara Hiroaki
Annals of Thoracic and Cardiovascular Surgery advpub(0), 1111140106, 2011
NAID 130001257811

Two Cases of Cerebral Embolism Caused by Apical Thrombi in Midventricular Obstructive Cardiomyopathy

Takeda Ikuko,Sekine Mayu,Matsushima Hayato,Hosomi Naohisa,Nakamura Takeshi,Ohtsuki Toshiho,Yamawaki Takemori,Matsumoto Masayasu
Internal Medicine 50(9), 1059-1060, 2011
… Midventricular obstructive hypertrophic cardiomyopathy (MOHC) is a rare form of cardiomyopathy that was demonstrated to have caused embolic stroke in two patients. … In both cases, the embolic sources of stroke were thrombi in an apical aneurysm caused by turbulent stasis of blood flow and subsequent injury of myocardial endocardium. … Even without atrial fibrillation, apical aneurysm can induce emboligenic stroke in MOHC. …
NAID 130000650113

Abnormal Myocardial Capillary Density in Apical Hypertrophic Cardiomyopathy Can Be Assessed by Myocardial Contrast Echocardiography

MOON Jeonggeun,CHO In Jeong,SHIM Chi Young,HA Jong-Won,JANG Yangsoo,CHUNG Namsik,RIM Se-Joong
Circulation journal : official journal of the Japanese Circulation Society 74(10), 2166-2172, 2010-09-25
… Background: Myocardial ischemia and dysfunction can occur in hypertrophic cardiomyopathy (HCM) because of the high muscle-to-blood ratio, even without significant coronary artery disease. … The hypothesis explored in the present study was that an abnormal capillary density in apical HCM (ApHCM) can be demonstrated using myocardial contrast echocardiography (MCE). …
NAID 10026640521