アモバルビタールナトリウム

関: amobarbital

WordNet

a silvery soft waxy metallic element of the alkali metal group; occurs abundantly in natural compounds (especially in salt water); burns with a yellow flame and reacts violently in water; occurs in sea water and in the mineral halite (rock salt) (同)Na, atomic number 11
a barbiturate with sedative and hypnotic effects; used to relieve insomnia and as an anticonvulsant

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ソジウム,ナトリウム(金属元素;化学記号はNa)

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/11/04 00:16:09」(JST)

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Amobarbital (formerly known as amylobarbitone or sodium amytal) is a drug that is a barbiturate derivative. It has sedative-hypnotic properties. It is a white crystalline powder with no odor and a slightly bitter taste. It was first synthesized in Germany in 1923. If amobarbital is taken for extended periods of time, physical and psychological dependence can develop. Amobarbital dependence mimics delirium tremens and may be life-threatening.

Pharmacology

In an in vitro study in rat thalamic slices amobarbital worked by activating GABA_A receptors, which decreased input resistance, depressed burst and tonic firing, especially in ventrobasal and intralaminar neurons, while at the same time increasing burst duration and mean conductance at individual chloride channels; this increased both the amplitude and decay time of inhibitory postsynaptic currents.^[1]

Amobarbital has been used in a study to inhibit mitochondrial electron transport in the rat heart.^[2]

A 1988 study found that amobarbital increases benzodiazepine receptor binding in vivo with less potency than secobarbital and pentobarbital (in descending order), but greater than phenobarbital and barbital (in descending order).^[3]

It has an LD₅₀ in mice of 212 mg/kg s.c.^{[citation needed]}

Metabolism

Amobarbital undergoes both hydroxylation to form 3'-hydroxyamobarbital,^[4] and N-glucosidation^[5] to form 1-(beta-D-glucopyranosyl)amobarbital.^[6]

Indications

Approved

Anxiety
Epilepsy
Insomnia
Wada test

Unapproved/off-label

When given slowly by an intravenous route, sodium amobarbital has a reputation for acting as a so-called truth serum. Under the influence, a person will divulge information that under normal circumstances they would block. As such, the drug was first employed clinically by Dr. William Bleckwenn at the University of Wisconsin to circumvent inhibitions in psychiatric patients.^[7] The use of amobarbital as a truth serum has lost credibility due to the discovery that a subject can be coerced into having a "false memory" of the event.^[8]

The drug may be used intravenously to interview patients with catatonic mutism, sometimes combined with caffeine to prevent sleep.^[9]

It was used by the United States armed forces during World War II in an attempt to treat shell shock and return soldiers to the front-line duties.^[10] This use has since been discontinued as the powerful sedation, cognitive impairment, and dis-coordination induced by the drug greatly reduced soldiers' usefulness in the field.

Contraindications

A vial of amytal sodium

The following drugs should be avoided when taking amobarbital:

Antiarrhythmics, such as verapamil and digoxin
Antiepileptics, such as phenobarbital or carbamazepine
Antihistamines, such as doxylamine and clemastine
Antihypertensives, such as atenolol and propranolol
Alcohol^{[citation needed]}
Benzodiazepines, such as diazepam, clonazepam or nitrazepam
Caffeine^{[citation needed]}
Chloramphenicol
Chlorpromazine
Cyclophosphamide
Ciclosporin
Digitoxin
Doxorubicin
Doxycycline
Methoxyflurane
Metronidazole
Narcotic analgesics, such as morphine and oxycodone
Quinine
Steroids, such as prednisone and cortisone
Theophylline
Warfarin

Interactions

Amobarbital has been known to decrease the effects of hormonal birth control, sometimes to the point of uselessness.^{[citation needed]} Being chemically related to phenobarbital, it might also do the same thing to digitoxin, a cardiac glycoside.^{[citation needed]}

Overdose

Some side effects of overdose include confusion (severe); decrease in or loss of reflexes; drowsiness (severe); fever; irritability (continuing); low body temperature; poor judgment; shortness of breath or slow or troubled breathing; slow heartbeat; slurred speech; staggering; trouble in sleeping; unusual movements of the eyes; weakness (severe).

Chemistry

Amobarbital (5-ethyl-5-isoamylbarbituric acid), like all barbiturates, is synthesized by reacting malonic acid derivatives with urea derivatives. In particular, in order to make amobarbital, α-ethyl-α-isoamylmalonic ester is reacted with urea (in the presence of sodium ethoxide).^[11]^[12]

Society and culture

It has been used to convict alleged murderers such as Andres English-Howard, who strangled his girlfriend to death but claimed innocence. He was surreptitiously administered the drug by his lawyer, and under the influence of it he revealed why he strangled her and under what circumstances. A year later he confessed on the witness stand and was convicted on the basis of these statements. He later committed suicide in his cell.^[13]

On the night of August 28, 1951, Robert Walker's housekeeper found the actor in an emotional state. She called Walker's psychiatrist who arrived and administered amobarbital for sedation. Walker was allegedly drinking prior to his emotional outburst, and it is believed the combination of amobarbital and alcohol resulted in a severe reaction. As a result, he passed out and stopped breathing, and all efforts to resuscitate him failed. Walker died at 32 years old.

References and end notes

^ Kim, H. -S.; Wan, X.; Mathers, D. A.; Puil, E. (2004). "Selective GABA-receptor actions of amobarbital on thalamic neurons". British Journal of Pharmacology 143 (4): 485–494. doi:10.1038/sj.bjp.0705974. PMC 1575418. PMID 15381635.
^ Stewart, S.; Lesnefsky, E. J.; Chen, Q. (2009). "Reversible blockade of electron transport with amobarbital at the onset of reperfusion attenuates cardiac injury". Translational Research 153 (5): 224–231. doi:10.1016/j.trsl.2009.02.003. PMID 19375683.
^ Miller, L. G.; Deutsch, S. I.; Greenblatt, D. J.; Paul, S. M.; Shader, R. I. (1988). "Acute barbiturate administration increases benzodiazepine receptor binding in vivo". Psychopharmacology 96 (3): 385–390. doi:10.1007/BF00216067. PMID 2906155.
^ Maynert, E. W. (1965). "The alcoholic metabolites of pentobarbital and amobarbital in man". The Journal of Pharmacology and Experimental Therapeutics 150 (1): 118–121. PMID 5855308.
^ Tang, B. K.; Kalow, W.; Grey, A. A. (1978). "Amobarbital metabolism in man: N-glucoside formation". Research communications in chemical pathology and pharmacology 21 (1): 45–53. PMID 684279.
^ Soine, P. J.; Soine, W. H. (1987). "High-performance liquid chromatographic determination of the diastereomers of 1-(beta-D-glucopyranosyl)amobarbital in urine". Journal of chromatography 422: 309–314. doi:10.1016/0378-4347(87)80468-1. PMID 3437019.
^ Bleckwenn, W. J. (1930). "Sodium amytal in certain nervous and mental conditions". Wisconsin Medical Journal 29: 693–696.
^ Stocks, J. T. (1998). "Recovered memory therapy: A dubious practice technique". Social work 43 (5): 423–436. doi:10.1093/sw/43.5.423. PMID 9739631.
^ McCall, W. V. (1992). "The addition of intravenous caffeine during an amobarbital interview". Journal of psychiatry & neuroscience : JPN 17 (5): 195–197. PMC 1188455. PMID 1489761.
^ "Use of sodium amytal during WWII". Battle of the Bulge - program transcript. PBS. Ben Kimmelman, Captain, 28th Infantry: The assumptions were that this would have some kind of cathartic effect, the sodium amytal, which the men called blue 88's. You know, the most effective artillery piece of the Germans was the 88 and this was blue 88s, because the sodium amytal was a blue tablet.
^ GB patent 191008, Layraud, E., "The manufacture of unsymmetrical c.c.-dialkylbarbituric acids", issued 1923-10-25
^ US patent 1856792, Shonle, H. A., "Anhydrous alkali salts of 5,5-di-aliphatic-substituted barbituric acids and processes of producing them", issued 1932-05-03
^ Rebecca Leung (February 11, 2009). "Truth Serum: A Possible Weapon". 60 Minutes. CBS News.

UpToDate Contents

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Japanese Journal

Confirmation of Nonconvulsive Limbic Status Epilepticus with the Sodium Amytal Test

BURNEO Jorge G.,KNOWLTON Robert C.,GOMEZ Camilo,MARTIN Roy,KUZNIECKY Ruben I.
Epilepsia : journal of the International League against Epilepsy 44(8), 1122-1126, 2003-08-01
NAID 10011926054

Selective Middle Cerebral Artery Wada Tests as a Part of Presurgical Evaluation in Patients with Drug-resistant Epilepsies

URBACH Horst,VON OERTZEN Joachim,KLEMM Edzard,KOENIG Roy,LINKE Detlef B.,KURTHEN Martin,SHRAMM Johannes,ELGER Christian E.
Epilepsia : journal of the International League against Epilepsy 43(10), 1217-1223, 2002-10-01
NAID 10010878813

Sodium Methohexital (Brevital) as an Anesthetic in the Wada Test

BUCHTEL Henry A.,PASSARO Erasmo A.,SELWA Linda M.,DEVEIKIS John,GOMEZ-HASSAN Diana
Epilepsia : journal of the International League against Epilepsy 43(9), 1056-1061, 2002-09-01
NAID 10010878133

「アモバルビタール」

Amobarbital
Systematic (IUPAC) name
	5-ethyl-5-(3-methylbutyl)-1,3-diazinane-2,4,6-trione
Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Pregnancy; category	?;
Legal status	CA: Schedule IV; DE: Anlage III; Schedule II/Schedule III (US);
Routes of; administration	Oral, IM, IV, Rectal
Pharmacokinetic data
Bioavailability	?
Metabolism	Hepatic
Biological half-life	8–42 hours
Excretion	Renal
Identifiers
CAS Registry Number	57-43-2 64-43-7 (sodium salt)
ATC code	N05CA02
PubChem	CID: 2164
DrugBank	DB01351
ChemSpider	2079
UNII	GWH6IJ239E
KEGG	D00555
ChEBI	CHEBI:2673
ChEMBL	CHEMBL267894
Chemical data
Formula	C11H18N2O3
Molecular mass	226.272
	SMILES O=C1NC(=O)NC(=O)C1(CCC(C)C)CC ;
	InChI InChI=1S/C11H18N2O3/c1-4-11(6-5-7(2)3)8(14)12-10(16)13-9(11)15/h7H,4-6H2,1-3H3,(H2,12,13,14,15,16) ; Key:VIROVYVQCGLCII-UHFFFAOYSA-N ;
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　　[★]

英: amobarbital、amobarbital sodium
ラ: amobarbitalum
同: アミロバルビトン amylobarbitone
商: イソミタール、イソミタールソーダ
関: アモバルビタールナトリウム。アミタール

「アモバルビタールナトリウム」

　　[★]

英: amobarbital sodium
関: アモバルビタール

「amobarbital」

　　[★] アモバルビタール　

[1] Kim, H. -S.; Wan, X.; Mathers, D. A.; Puil, E. (2004). "Selective GABA-receptor actions of amobarbital on thalamic neurons". British Journal of Pharmacology 143 (4): 485–494. doi:10.1038/sj.bjp.0705974. PMC 1575418. PMID 15381635.

[2] Stewart, S.; Lesnefsky, E. J.; Chen, Q. (2009). "Reversible blockade of electron transport with amobarbital at the onset of reperfusion attenuates cardiac injury". Translational Research 153 (5): 224–231. doi:10.1016/j.trsl.2009.02.003. PMID 19375683.

[3] Miller, L. G.; Deutsch, S. I.; Greenblatt, D. J.; Paul, S. M.; Shader, R. I. (1988). "Acute barbiturate administration increases benzodiazepine receptor binding in vivo". Psychopharmacology 96 (3): 385–390. doi:10.1007/BF00216067. PMID 2906155.

[4] Maynert, E. W. (1965). "The alcoholic metabolites of pentobarbital and amobarbital in man". The Journal of Pharmacology and Experimental Therapeutics 150 (1): 118–121. PMID 5855308.

[5] Tang, B. K.; Kalow, W.; Grey, A. A. (1978). "Amobarbital metabolism in man: N-glucoside formation". Research communications in chemical pathology and pharmacology 21 (1): 45–53. PMID 684279.

[6] Soine, P. J.; Soine, W. H. (1987). "High-performance liquid chromatographic determination of the diastereomers of 1-(beta-D-glucopyranosyl)amobarbital in urine". Journal of chromatography 422: 309–314. doi:10.1016/0378-4347(87)80468-1. PMID 3437019.

[7] Bleckwenn, W. J. (1930). "Sodium amytal in certain nervous and mental conditions". Wisconsin Medical Journal 29: 693–696.

[Stocks-8] Stocks, J. T. (1998). "Recovered memory therapy: A dubious practice technique". Social work 43 (5): 423–436. doi:10.1093/sw/43.5.423. PMID 9739631.

[9] McCall, W. V. (1992). "The addition of intravenous caffeine during an amobarbital interview". Journal of psychiatry & neuroscience : JPN 17 (5): 195–197. PMC 1188455. PMID 1489761.

[10] "Use of sodium amytal during WWII". Battle of the Bulge - program transcript. PBS. Ben Kimmelman, Captain, 28th Infantry: The assumptions were that this would have some kind of cathartic effect, the sodium amytal, which the men called blue 88's. You know, the most effective artillery piece of the Germans was the 88 and this was blue 88s, because the sodium amytal was a blue tablet.

[11] GB patent 191008, Layraud, E., "The manufacture of unsymmetrical c.c.-dialkylbarbituric acids", issued 1923-10-25

[12] US patent 1856792, Shonle, H. A., "Anhydrous alkali salts of 5,5-di-aliphatic-substituted barbituric acids and processes of producing them", issued 1932-05-03

[CBS-13] Rebecca Leung (February 11, 2009). "Truth Serum: A Possible Weapon". 60 Minutes. CBS News.

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amobarbital sodium