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Single-step approach for fabrication of vancomycin-bonded silica monolith as chiral stationary phase.

Hsieh ML1, Chau LK2, Hon YS1.
Journal of chromatography. A.J Chromatogr A.2014 Sep 5;1358:208-16. doi: 10.1016/j.chroma.2014.07.003. Epub 2014 Jul 9.
A vancomycin-bonded silica monolithic column for capillary electrochromatography (CEC) was prepared by a single-step in situ sol-gel approach. This sol-gel process incorporates a synthetic sol-gel precursor which contains a macrocyclic antibiotic, vancomycin, to form a porous silica network inside a
PMID 25047820

Clarithromycin as a chiral selector for enantioseparation of basic compounds in NACE.

Lebedeva MV1, Prokhorova AF, Shapovalova EN, Shpigun OA.
Electrophoresis.Electrophoresis.2014 Aug 5. doi: 10.1002/elps.201400135. [Epub ahead of print]
The first use of macrolide antibiotic clarithromycin (CLM) in non-aqueous media for enantioseparation (partial or baseline) of the following compounds: alprenolol, atenolol, metoprolol, clenbuterol, methoxyphenamine, pindolol, propranolol, sotalol, synephrine, labetalol, and fenoterol is reported. E
PMID 25100556

Enantiomeric fraction evaluation of pharmaceuticals in environmental matrices by liquid chromatography-tandem mass spectrometry.

Ribeiro AR1, Santos LH2, Maia AS3, Delerue-Matos C4, Castro PM5, Tiritan ME6.
Journal of chromatography. A.J Chromatogr A.2014 Jul 8. pii: S0021-9673(14)01044-9. doi: 10.1016/j.chroma.2014.06.099. [Epub ahead of print]
The interest for environmental fate assessment of chiral pharmaceuticals is increasing and enantioselective analytical methods are mandatory. This study presents an enantioselective analytical method for the quantification of seven pairs of enantiomers of pharmaceuticals and a pair of a metabolite.
PMID 25047821

山口敬子,村瀬裕成,森逸男 [他],藤田芳一
分析化学 50(8), 563-566, 2001-08-05
… A spectrophotometric method for the determination of propranolol hydrochloride(PP) was established by using the Bromopyrogallol Red(BPR)-molybdenum(VI) complex. … Moreover, this method could be applied to the assay of drugs, such as chlorpromazine and alprenolol. …
NAID 110002905972

Relationship between Desensitization and Downregulation of B-Adrenoceptors in Cardiac Tissues after Prolonged In Vivo Infusion of T-0509,aB1-Adrenoceptor Agonist

Sato Yoji,Kurose Hitoshi,Nagao Taku
The Japanese journal of pharmacology 73(4), 325-332, 1997-04-01
… To examine the contribution of β-adrenoceptor (βAR) downregulation to desensitization of βARs by chronic administration of a βAR agonist, we compared the adenylyl cyclase (AC) activities in two kinds of cardiac ventricular membranes with decreased available βARs: one was derived from rats infused with a selective β<SUB>1</SUB>AR agonist, T-0509 [(－)-(<I>R</I>)-1-(3, 4-dihydroxyphenyl)-2-[(3, 4-dimethoxyphenethyl)amino]ethanol hydrochloride], in vivo (40 μg/kg/hr, s.c. …
NAID 10008677828