関: alimemazine tartrate、trimeprazine

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/11/21 22:11:35」(JST)

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Alimemazine (INN), also known as trimeprazine (former BAN and USAN; brand names Nedeltran, Panectyl, Repeltin, Therafene, Theraligene, Theralen, Theralene, Vallergan, Vanectyl, and Temaril), commonly provided as a tartrate salt, is a phenothiazine derivative that is used as an antipruritic (it prevents itching from causes such as eczema or poison ivy, by acting as an antihistamine).^[2] It also acts as a sedative, hypnotic, and antiemetic for prevention of motion sickness. Although it is structurally related to drugs such as chlorpromazine, it is not used as an antipsychotic treatment.^[3] It is marketed and used as an anxiolytic in Russian Federation.

In veterinary use, the combination of alimemazine and prednisolone is licensed as an antipruritic and antitussive in dogs.

References[edit]

^ Hu OY, Gfeller E, Perrin JH, Curry SH (March 1986). "Relative bioavailability of trimeprazine tablets investigated in man using HPLC with electrochemical detection". The Journal of Pharmacy and Pharmacology 38 (3): 172–6. PMID 2871150.
^ "PubChem CID 78032".
^ "Drugbank:Trimeprazine".

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English Journal

Sedation for children 2 to 5 years of age undergoing auditory brainstem response and auditory steady state responses recordings.

François M, Teissier N, Barthod G, Nasra Y.SourceENT Department, Robert Debré Hospital , Paris , France.
International journal of audiology.Int J Audiol.2012 Apr;51(4):282-6. Epub 2011 Sep 22.
Abstract Objective: To evaluate the feasibility, the duration and results of sedation by intrarectal pentobarbital and oral alimemazine for auditory brain stem responses (ABR) and auditory steady-state responses (ASSR) recordings in children aged 2 to 5 years. Design: Prospective study. Study samp
PMID 21936745

Determination of enantiomeric excess by chiral liquid chromatography without enantiomerically pure starting standards.

Sánchez FG, Navas Díaz A, Sánchez Torreño E, Aguilar A, Medina Lama I, Algarra M.SourceDepartment of Analytical Chemistry, Faculty of Sciences, University of Malaga, 2071-Malaga, Spain. f_garcia@uma.es.
Biomedical chromatography : BMC.Biomed Chromatogr.2012 Feb 7. doi: 10.1002/bmc.2685. [Epub ahead of print]
A facile approach for the enantiomeric excess determination of enantiomeric mixtures without the necessity of pure enantiomer standards is presented. Promethazine and trimeprazine commercial nonracemic mixtures were used as cases study to probe the validity of the method. Chromatographic resolutions
PMID 22311573

Japanese Journal

Inflammatory Action of 8-Methoxypsoralen-Spermine Photoproduct (8-MOP-Spm-P_<GFC>) and Effects of Various Drugs on Rat Paw Edema Induced by 8-MOP-Spm-P_<GFC>

SHIGEHARA Noriko,MIYATAKA Hideki,KAKEGAWA Hisao,NISHIKI Mayumi,MATSUMOTO Hitoshi,ISOBE Akihiko,SATOH Toshio
Biological & pharmaceutical bulletin 22(11), 1202-1206, 1999-11-15
… As a results, edema formation was inhibited by drugs with an anti-histaminic action, such as alimemazine, dl-chlorpheniramine, promethazine, ketotifen and azelastine, and with anti-serotonin action such as cyproheptadine. …
NAID 110003639575

Antimuscarinic Effects of Antihistamines: Quantitative Evaluation by Receptor-Binding Assay

KUBO Nobuo,SHIRAKAWA Osamu,KUNO Takayoshi,TANAKA Chikako
The Japanese Journal of Pharmacology 43(3), 277-282, 1987
… On the other hand, some H<SUB>1</SUB>-receptor antagonists (mequitazine, cyproheptazine, clemastine, diphenylpyraline, promethazine, homochlorcyclizine and alimemazine) had high affinity for the muscarinic receptors (K<SUB>1</SUB>=5.0-38 nM). …
NAID 130000833420

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★リンクテーブル★

リンク元	「アリメマジン」「trimeprazine」
拡張検索	「alimemazine tartrate」

「アリメマジン」

Alimemazine
Systematic (IUPAC) name
	N,N,2-trimethyl-3-phenothiazin-10-yl-propan-1-amine
Clinical data
AHFS/Drugs.com	International Drug Names
MedlinePlus	a600010
Pregnancy cat.	C (AU)
Legal status	?
Routes	Oral
Pharmacokinetic data
Metabolism	Hepatic
Half-life	4.78 ± 0.59 hours
Identifiers
CAS number	84-96-8
ATC code	D04AA10 R06AD02, R06AD05
PubChem	CID 5574
DrugBank	DB01246
ChemSpider	5373
UNII	76H78MJJ52
KEGG	D07125
ChEMBL	CHEMBL829
Chemical data
Formula	C18H22N2S
Mol. mass	298.447 g/mol
	SMILES S2c1ccccc1N(c3c2cccc3)CC(C)CN(C)C;
	InChI InChI=1S/C18H22N2S/c1-14(12-19(2)3)13-20-15-8-4-6-10-17(15)21-18-11-7-5-9-16(18)20/h4-11,14H,12-13H2,1-3H3 ; Key:ZZHLYYDVIOPZBE-UHFFFAOYSA-N ;
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