関: alimemazine

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/01/16 20:40:57」(JST)

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Alimemazine (INN), also known as trimeprazine (former BAN and USAN; brand names Nedeltran, Panectyl, Repeltin, Therafene, Theraligene, Theralen, Theralene, Vallergan, Vanectyl, and Temaril), commonly provided as a tartrate salt, is a phenothiazine derivative that is used as an antipruritic (it prevents itching from causes such as eczema or poison ivy, by acting as an antihistamine).^[2] It also acts as a sedative, hypnotic, and antiemetic for prevention of motion sickness. Although it is structurally related to drugs such as chlorpromazine, it is not used as an antipsychotic treatment.^[3] It is marketed and used as an anxiolytic in Russian Federation.

In veterinary use, the combination of alimemazine and prednisolone is licensed as an antipruritic and antitussive in dogs.

References[edit]

^ Hu OY, Gfeller E, Perrin JH, Curry SH (March 1986). "Relative bioavailability of trimeprazine tablets investigated in man using HPLC with electrochemical detection". The Journal of Pharmacy and Pharmacology 38 (3): 172–6. PMID 2871150.
^ "PubChem CID 78032".
^ "Drugbank:Trimeprazine".

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English Journal

Determination of enantiomeric excess by chiral liquid chromatography without enantiomerically pure starting standards.

Sánchez FG, Navas Díaz A, Sánchez Torreño E, Aguilar A, Medina Lama I, Algarra M.SourceDepartment of Analytical Chemistry, Faculty of Sciences, University of Malaga, Malaga, Spain. f_garcia@uma.es
Biomedical chromatography : BMC.Biomed Chromatogr.2012 Oct;26(10):1241-6. doi: 10.1002/bmc.2685. Epub 2012 Feb 7.
A facile approach for the enantiomeric excess determination of enantiomeric mixtures without the necessity of pure enantiomer standards is presented. Promethazine and trimeprazine commercial nonracemic mixtures were used as cases study to probe the validity of the method. Chromatographic resolutions
PMID 22311573

A new method for quantitative determination of dimemorfan in human plasma using monolithic silica solid-phase extraction tips.

Hasegawa C, Kumazawa T, Terada M, Lee XP, Sato K, Uchigasaki S, Kurosaki K.SourceDepartment of Legal Medicine, Toho University School of Medicine, 5-21-16 Omorinishi, Ota-ku, Tokyo 143-8540, Japan. chika99@med.toho-u.ac.jp
Legal medicine (Tokyo, Japan).Leg Med (Tokyo).2012 Sep;14(5):267-71. doi: 10.1016/j.legalmed.2012.03.004. Epub 2012 Apr 28.
Dimemorfan was extracted from human plasma samples (100 μL) using MonoTip C(18) tips, which were packed with a C(18)-bonded monolithic silica gel attached to the inside of the tip. The samples, which contained dimemorfan and trimeprazine as an internal standard (IS), were mixed with 300 μL of dist
PMID 22546247

Case Report of Atopic Dermatitis with Refractory Pruritus Markedly Improved with the Novel Use of Clonidine and Trimeprazine.

Genois A, Haig M, Roches AD, Sirard A, Le May S, McCuaig CC.SourceFaculty of MedicineDepartments of Anesthesia Services of Allergy and Immunology Pediatrics Dermatology, CHU Sainte Justine Department of Nursing, University of Montreal, Montreal, Quebec, Canada.
Pediatric dermatology.Pediatr Dermatol.2012 Jul 2. doi: 10.1111/j.1525-1470.2012.01756.x. [Epub ahead of print]
We report a 6-year-old boy with severe atopic dermatitis and refractory pruritus. The novel use of clonidine, an adrenergic agonist, along with trimeprazine, led to dramatic improvement. This represents the first case report of clonidine's effect in relieving pruritus in atopic dermatitis.© 201
PMID 22747704

Japanese Journal

Phenothiazine類およびPhenoxazine類の抗腫瘍性試験

本橋登
藥學雜誌 103(3), 364-371, 1983-03-25
… The compounds which exhibited over 50% Ratio [(sample tumor weight/control tumor weight)×100] in forty-eight compounds were ten, that is, 2-chloro-5-oxo-5H-phenothiazine (4), ethopromazine hydrochloride (7), chlorpromazine hydrochloride (8), perazine dimaleate (11), fluphenazine dimaleate (12), trimeprazine tartrate (13), trimeprazine dimaleate (14), trimeprazine hydrochloride (15), 9-methyl-12H-benzo [α] phenothiazine (16) and 4-hydroxy-9-oxo-9H-benzo [α] phenoxazine (39). …
NAID 110003650472

Effects of trimeprazine and trimipramine on nocturnal scratching in patients with atopic eczema

SAVIN JA
Arch Dermatol 115, 313-315, 1979
NAID 30005391940

Related Pictures

★リンクテーブル★

リンク元	「alimemazine」「トリメプラジン」
拡張検索	「methotrimeprazine」

「alimemazine」

Alimemazine
Systematic (IUPAC) name
	N,N,2-trimethyl-3-phenothiazin-10-yl-propan-1-amine
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	C (AU)
Legal status	?
Routes	Oral
Pharmacokinetic data
Metabolism	Hepatic
Half-life	4.78 ± 0.59 hours
Identifiers
CAS number	84-96-8
ATC code	R06AD01
PubChem	CID 5574
DrugBank	DB01246
ChemSpider	5373
UNII	76H78MJJ52
KEGG	D07125
ChEMBL	CHEMBL829
Chemical data
Formula	C18H22N2S
Mol. mass	298.447 g/mol
	SMILES S2c1ccccc1N(c3c2cccc3)CC(C)CN(C)C;
	InChI InChI=1S/C18H22N2S/c1-14(12-19(2)3)13-20-15-8-4-6-10-17(15)21-18-11-7-5-9-16(18)20/h4-11,14H,12-13H2,1-3H3 ; Key:ZZHLYYDVIOPZBE-UHFFFAOYSA-N ;
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