関: lorajmine

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/11/14 15:39:05」(JST)

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Ajmaline is an alkaloid that is class Ia antiarrhythmic agent. It is often used to bring out typical findings of ST elevations in patients suspected of having Brugada syndrome.

The compound was first isolated by Salimuzzaman Siddiqui in 1931 ^[1] from the roots of Rauwolfia serpentina. He named it ajmaline, after Hakim Ajmal Khan, one of the most illustrious practitioners of Unani medicine in South Asia.^[2]

References[edit]

^ Siddiqui, S.; Siddiqui, R. H. (1931). J. Indian Chem. Soc. 8: 667–80.
^ Ahmed Nasim Sandilvi (2003), Salimuzzaman Siddiqui: pioneer of scientific research in Pakistan. Daily Dawn. 12 April 2003. Retrieved on 19 July 2007.

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1. ブルガダ症候群および突然の心停止 brugada syndrome
2. 右脚ブロック right bundle branch block

English Journal

Macroline, akuammiline, sarpagine, and ajmaline alkaloids from Alstonia macrophylla.

Lim SH1, Low YY1, Sinniah SK2, Yong KT2, Sim KS2, Kam TS3.Author information 1Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia.2Institute of Biological Sciences, University of Malaya, 50603 Kuala Lumpur, Malaysia.3Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia. Electronic address: tskam@um.edu.my.AbstractA total of seventeen alkaloids, comprising six macroline (including alstofolinine A, a macroline indole incorporating a butyrolactone ring-E), two ajmaline, one sarpagine, and eight akuammiline alkaloids, were isolated from the stem-bark and leaf extracts of the Malayan Alstonia macrophylla. The structure and relative configurations of these alkaloids were established using NMR, MS and in several instances, confirmed by X-ray diffraction analysis. Six of these alkaloids were effective in reversing multidrug-resistance (MDR) in vincristine-resistant KB cells.
Phytochemistry.Phytochemistry.2014 Feb;98:204-15. doi: 10.1016/j.phytochem.2013.11.014. Epub 2013 Dec 13.
A total of seventeen alkaloids, comprising six macroline (including alstofolinine A, a macroline indole incorporating a butyrolactone ring-E), two ajmaline, one sarpagine, and eight akuammiline alkaloids, were isolated from the stem-bark and leaf extracts of the Malayan Alstonia macrophylla. The str
PMID 24342109

Combined HPLC-DAD-MS, HPLC-MS(n) and NMR spectroscopy for quality control of plant extracts: the case of a commercial blend sold as dietary supplement.

Karioti A, Giocaliere E, Guccione C, Pieraccini G, Gallo E, Vannacci A, Bilia AR.Author information Department of Chemistry, Building of Pharmaceutical Sciences, University of Florence, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Firenze, Italy. Electronic address: anastasiakarioti@yahoo.it.AbstractThe efficiency of 1D and 2D NMR spectroscopy along with HPLC-DAD-MS analyses in characterising the content of a dietary supplement is demonstrated. Experiments directly performed on a lyophilised sample of a commercial product gave details on the quality control of the product. The lack of the marker constituents of some of the declared plant species (Crataegus oxyacantha, Olea europea, Capsella bursa-pastoris and Fumaria officinalis) and the presence of banned adulterants, responsible for the strong antihypertensive effect of the supplement were established. The analyses proved the presence of indole alkaloids belonging to the group of Rauwolfia sp., such as ajmaline, reserpine and yohimbine. Quantitative HPLC analysis showed that the content of reserpine in the product was in the therapeutic range and therefore responsible for the collapses of the patients.
Journal of pharmaceutical and biomedical analysis.J Pharm Biomed Anal.2014 Jan 25;88:7-15. doi: 10.1016/j.jpba.2013.07.040. Epub 2013 Aug 7.
The efficiency of 1D and 2D NMR spectroscopy along with HPLC-DAD-MS analyses in characterising the content of a dietary supplement is demonstrated. Experiments directly performed on a lyophilised sample of a commercial product gave details on the quality control of the product. The lack of the marke
PMID 24013031

The clinical impact of ajmaline challenge in elderly patients with suspected atrioventricular conduction disease.

Conte G1, Levinstein M2, Sarkozy A2, Sieira J2, de Asmundis C2, Chierchia GB2, Di Giovanni G2, Baltogiannis G2, Ciconte G2, Wauters K2, Pappaert G2, Brugada P2.Author information 1Heart Rhythm Management Centre, UZ Brussel-VUB, Brussels, Belgium. Electronic address: giulioconte.cardio@gmail.com.2Heart Rhythm Management Centre, UZ Brussel-VUB, Brussels, Belgium.AbstractBACKGROUND: The effects and the safety of ajmaline challenge in elderly patients with suspected atrioventricular (AV) conduction disease have not been systematically investigated. The purpose of this study was to assess the response of intravenous administration of ajmaline in patients older than 75years suspected to be affected by AV conduction disease with respect to unmask high-degree His-Purkinje block or the typical Brugada ECG pattern.
International journal of cardiology.Int J Cardiol.2014 Jan 24. pii: S0167-5273(14)00314-3. doi: 10.1016/j.ijcard.2014.01.103. [Epub ahead of print]
BACKGROUND: The effects and the safety of ajmaline challenge in elderly patients with suspected atrioventricular (AV) conduction disease have not been systematically investigated. The purpose of this study was to assess the response of intravenous administration of ajmaline in patients older than 75
PMID 24486065

Japanese Journal

数種の植物成分の生合成におけるシトクロムP450酸化酵素の反応と機能

井上謙一郎
藥學雜誌 125(1), 31-49, 2005-01-01
シトクロムP450モノオキシゲナーゼは動植物から微生物に至るまで広く生物界に分布していることが知られている. 動物において薬物やステロイドホルモンの代謝にP450が関与することが示されたことより, まず個体及び無細胞系レベルでそれらの機能が, 続いてP450の酵素化学的性質が分子レベルで解析され, 1980年代後半遺伝子工学技術の発展に伴いDNAレベルでの研究が急速に進み, 多くのデータが蓄積され …
NAID 110003666156

Value of electrocardiographic parameters and ajmaline test in the diagnosis of Brugada syndrome caused by SCN5A mutations

HONG K
Circulation 110, 3023-3027, 2004
NAID 30022671821

「アジマリン」

Ajmaline
Systematic (IUPAC) name
	(17R,21β)-ajmalan- 17,21-diol; OR; (1R,9R,10S,13R,14R,16S,18S)- 13-ethyl- 8-methyl- 8,15-diazahexacyclo [14.2.1.01,9.02,7.010,15.012,17] nonadeca- 2(7),3,5-triene- 14,18-diol
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	4360-12-7
ATC code	C01BA05
PubChem	CID 20367
DrugBank	DB01426
ChemSpider	10469368
UNII	1PON08459R
KEGG	D00199
ChEMBL	CHEMBL1230919
Chemical data
Formula	C20H26N2O2
Mol. mass	326.433 g/mol
	SMILES CC[C@H]1[C@H]5C[C@@H]4N([C@@H]1O)[C@H]6C[C@]3(c2ccccc2N(C)[C@H]34)[C@H](O)C56;
	InChI InChI=1S/C20H26N2O2/c1-3-10-11-8-14-17-20(12-6-4-5-7-13(12)21(17)2)9-15(16(11)18(20)23)22(14)19(10)24/h4-7,10-11,14-19,23-24H,3,8-9H2,1-2H3/t10-,11+,14-,15-,16?,17-,18+,19+,20+/m0/s1 ; Key:CJDRUOGAGYHKKD-SXKXKDIKSA-N ;
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英: ajmaline
ラ: ajmalinum
商: リトモス
関: アジュマリン、ロラジミン

抗不整脈薬

Ia群抗不整脈薬

副作用に肝障害(胆汁うっ滞型薬物性肝障害)がある。副作用のため現在あまり用いられない。

「アジュマリン」

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英: ajmaline
関: アジマリン

「lorajmine」

　　[★]

ロラジミン

関: ajmaline

[1] Siddiqui, S.; Siddiqui, R. H. (1931). J. Indian Chem. Soc. 8: 667–80.

[sandilvi-2] Ahmed Nasim Sandilvi (2003), Salimuzzaman Siddiqui: pioneer of scientific research in Pakistan. Daily Dawn. 12 April 2003. Retrieved on 19 July 2007.

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ajmaline