関: ajmaline

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2019/07/22 16:20:50」(JST)

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Lorajmine (17-monochloroacetylajmaline) is a drug that is a potent sodium channel blocker (more specifically, a class Ia antiarrhythmic agent) that was used for treating arrhythmia.^[1]^[2] It is derived from ajmaline, an alkaloid from the roots of Rauwolfia serpentina, by synthetically adding a chloroacetate residue.

References

^ Medical Dictionary Online: Lorajmine
^ World Health Organization: ATC/DDD Index

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English Journal

Determination of lorajmine and its metabolite ajmaline in plasma and urine by a new high-performance liquid chromatographic method.

Padrini R1, Piovan D, Gaglione E, Zordan R, Ferrari M.
Therapeutic drug monitoring.Ther Drug Monit.1992 Oct;14(5):391-6.
Lorajmine is a monochloroacetyl derivative of ajmaline with electrophysiological properties somewhat different from those of the compound of origin. Since lorajmine is rapidly hydrolyzed to ajmaline by plasma and tissue esterases, it is crucial to measure plasma levels of both drugs separately. A ma
PMID 1448847

[Bidirectional tachycardia during therapy with lorajmine].

Lanza GA, Rebuzzi AG, Santarelli P, Tamburi S, Lucente M.
Cardiologia (Rome, Italy).Cardiologia.1989 Oct;34(10):893-6.
We report a case of bidirectional tachycardia (BT) found on Holter recording (H-ECG), likely due to antiarrhythmic therapy with lorajmine. The patient, who was not on digitalis therapy and had good myocardial function, was investigated for presyncope. H-ECG revealed frequent premature ventricular co
PMID 2605577

Worsening of arrhythmias during pharmacological treatment.

Furlanello F, Gramegna L, Dal Forno P, Vergara G, Bettini R, Inama G, Disertori M.
Giornale italiano di cardiologia.G Ital Cardiol.1984 Oct;14(10):798-803.
The widespread use of antiarrhythmic agents to control severe life-threatening arrhythmias evidenced the possibility of a worsening of arrhythmias induced by the same drugs. We performed a retrospective analysis studying the worsening phenomenon in patients who underwent pharmacological invasive and
PMID 6440827

「ajmaline」

Lorajmine
Clinical data
ATC code	C01BA12 (WHO) ;
Identifiers
	IUPAC name (17R,21β)-ajmalan-17,21-diol 17-chloroacetate; OR; (1R,9R,10S,13R,14R,16S,18S)-13-ethyl-8-methyl-14-hydroxy-8,15-diazahexacyclo [14.2.1.01,9.02,7.010,15.012,17]nonadeca-2(7),3,5-triene-18-yl chloroacetate;
CAS Number	47562-08-3;
PubChem CID	76957773;
ChemSpider	16735878 ;
UNII	F96VX65849;
ChEMBL	ChEMBL2111031;
ECHA InfoCard	100.051.185
Chemical and physical data
Formula	C22H27ClN2O3
Molar mass	402.914 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCC1C2CC3C4C5(CC(C2C5C(=O)OCCl)N3C1O)C6=CC=CC=C6N4C;
	InChI InChI=1S/C22H27ClN2O3/c1-3-11-12-8-15-19-22(13-6-4-5-7-14(13)24(19)2)9-16(25(15)21(11)27)18(12)20(22)28-17(26)10-23/h4-7,11-12,15-16,18-21,27H,3,8-10H2,1-2H3/t11-,12-,15-,16-,18?,19-,20+,21+,22+/m0/s1 ; Key:LAHDERDHXJFFJU-KBFYUGGWSA-N ;
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アジマリン、アジュマリン

関: lorajmine

「ロラジミン」

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英: lorajmine
関: アジマリン

[1] Medical Dictionary Online: Lorajmine

[2] World Health Organization: ATC/DDD Index

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案内

lorajmine