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1. 反応性気道機能障害症候群および刺激に誘発された喘息 reactive airways dysfunction syndrome and irritant induced asthma
2. ウイルス誘発性の喘鳴および喘息：概要 virus induced wheezing and asthma an overview
3. 気管支誘発試験 bronchoprovocation testing
4. Asthma in children younger than 12 years: Epidemiology and pathophysiology
5. 喘息の病因 pathogenesis of asthma

English Journal

Asthma indicators and neighborhood and family stressors related to urban living in children.

Koinis-Mitchell D, Kopel SJ, Salcedo L, McCue C, McQuaid EL.SourceBradley/Hasbro Children's Research Center/The Warren Alpert Medical School of Brown University, Providence, RI, USA. Daphne_Koinis-Mitchell@Brown.edu.
American journal of health behavior.Am J Health Behav.2014 Jan;38(1):22-30. doi: 10.5993/AJHB.38.1.3.
OBJECTIVE: To examine differences in asthma outcomes by levels of child-reported neighborhood and family stress related to urban living in a sample of children and their caregivers.METHODS: A total of 208 urban children with asthma, ages 6-12 and their primary caregivers from African-American, Latin
PMID 24034677

Proof-of-concept evaluation of trough airway hyper-responsiveness following regular racemic or levosalbutamol in genotype-stratified steroid-treated persistent asthmatic patients.

Anderson WJ, Short PM, Williamson PA, Morrison AE, Palmer C, Tavendale R, Lipworth BJ.Source*Asthma and Allergy Research Group, Division of Cardiovascular and Diabetes Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, Scotland, U.K.
Clinical science (London, England : 1979).Clin Sci (Lond).2014 Jan 1;126(1):75-83. doi: 10.1042/CS20130213.
Asthmatic patients receiving ICSs (inhaled corticosteroids) may take frequent add-on therapy with salbutamol despite on-demand prescription. Frequent salbutamol use can be detrimental in asthma. The isomeric formulation of salbutamol and the B2ADR (β2 adrenoceptor) 16 genotype may also influence th
PMID 23829494

No exacerbation but impaired anti-viral mechanisms in a rhinovirus-chronic allergic asthma mouse model.

Rochlitzer S, Hoymann HG, Müller M, Braun A.AbstractSevere asthma and viral-induced asthma exacerbations represent a high unmet medical need as no therapy is currently available for these patients. HRV (human rhinovirus) is prominently associated with asthma exacerbations in humans. The aim of the present study was to establish a mouse model of severe asthma with additional rhinovirus infection to investigate the interplay between chronic allergic airway inflammation and acute respiratory viral infection. Balb/c mice were sensitized with HDM (house dust mite) extract (25 μg in 50 μl of saline) by i.n. (intranasal) delivery to the lung over 7 weeks. HRV1B (HRV serotype 1B) inoculation was performed i.n. on the last 3 days. Therapeutic treatment with FP (fluticasone propionate) was performed to assess steroid efficacy. Lung resistance was measured invasively to assess AHR (airway hyper-responsiveness). BAL (bronchoalveolar lavage) differential cell count, cytokines, lung histology and the proliferative and cytokine response of MLN (mediastinal lymph node) cells upon in vitro restimulation were analysed. Chronic HDM application induced a strong Th2-skewed eosinophilic airway inflammation and AHR, which was not exacerbated by superimposed HRV1B infection. Therapeutic steroid intervention in the chronic HDM model reduced BAL eosinophil cell counts, cytokine levels and AHR, while neutrophil numbers were unaffected. Steroid efficacy against inflammatory readouts was maintained during additional HRV1B infection. Animals with chronic allergic airway inflammation exhibited a diminished immune response towards superimposed HRV1B infection compared with HRV1B alone, as induction of the anti-viral and pro-inflammatory cytokines IFN (interferon)-α, IFN-γ and IL (interleukin)-12 were suppressed. Although superimposed HRV1B infection did not provoke asthma exacerbation in this severe model, a deficient anti-viral immune response to HRV1B was present under chronic allergic airway inflammatory conditions. Thus, this model is able to reflect some aspects of the complex interplay of respiratory virus infection in chronic allergic asthma.
Clinical science (London, England : 1979).Clin Sci (Lond).2014 Jan 1;126(1):55-65. doi: 10.1042/CS20130174.
Severe asthma and viral-induced asthma exacerbations represent a high unmet medical need as no therapy is currently available for these patients. HRV (human rhinovirus) is prominently associated with asthma exacerbations in humans. The aim of the present study was to establish a mouse model of sever
PMID 23822145