アデニル酸アミノヒドロラーゼ
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English Journal
- HIF-1α in the heart: remodeling nucleotide metabolism.
- Wu J1, Bond C1, Chen P1, Chen M1, Li Y1, Shohet RV2, Wright G3.
- Journal of molecular and cellular cardiology.J Mol Cell Cardiol.2015 May;82:194-200. doi: 10.1016/j.yjmcc.2015.01.014. Epub 2015 Feb 11.
- These studies have examined the effect of hypoxia inducible factor 1α (HIF-1α) on nucleotide metabolism in the ischemic heart using a genetic mouse model with heart-specific and regulated expression of a stable form of HIF-1α. We find that AMP deaminase (AMPD), the entry point of the purine nucle
- PMID 25681585
- The last enzyme of the de novo purine synthesis pathway 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC) plays a central role in insulin signaling and the Golgi/endosomes protein network.
- Boutchueng-Djidjou M1, Collard-Simard G1, Fortier S1, Hébert SS2, Kelly I3, Landry CR4, Faure RL5.
- Molecular & cellular proteomics : MCP.Mol Cell Proteomics.2015 Apr;14(4):1079-92. doi: 10.1074/mcp.M114.047159. Epub 2015 Feb 16.
- Insulin is internalized with its cognate receptor into the endosomal apparatus rapidly after binding to hepatocytes. We performed a bioinformatic screen of Golgi/endosome hepatic protein fractions and found that ATIC, which is a rate-limiting enzyme in the de novo purine biosynthesis pathway, and PT
- PMID 25687571
- AMPD1 regulates mTORC1-p70 S6 kinase axis in the control of insulin sensitivity in skeletal muscle.
- Tandelilin AA1,2, Hirase T3, Hudoyo AW4,5, Cheng J6,7, Toyama K8,9, Morisaki H10,11, Morisaki T12,13.
- BMC endocrine disorders.BMC Endocr Disord.2015 Mar 27;15:11. doi: 10.1186/s12902-015-0010-9.
- BACKGROUND: Insulin resistance triggered by excess fat is a key pathogenic factor that promotes type 2 diabetes. Understanding molecular mechanisms of insulin resistance may lead to the identification of a novel therapeutic target for type 2 diabetes. AMPD1, an isoform of AMP deaminase (AMPD), is su
- PMID 25887856
★リンクテーブル★
[★]
- 英
- adenylate aminohydrolase
- 関
- AMPデアミナーゼ
[★]
- 関
- adenosine monophosphate、adenylation、adenylic acid
[★]
アミノヒドロラーゼ