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English Journal

Effect of drug efflux transporters on placental transport of antiretroviral agent abacavir.

Neumanova Z1, Cerveny L1, Greenwood SL2, Ceckova M1, Staud F3.
Reproductive toxicology (Elmsford, N.Y.).Reprod Toxicol.2015 Nov;57:176-82. doi: 10.1016/j.reprotox.2015.07.070. Epub 2015 Jul 10.
Abacavir is as a frequent part of combination antiretroviral therapy used in pregnant women. The aim of this study was to investigate, using in vitro, in situ and ex vivo experimental approaches, whether the transplacental pharmacokinetics of abacavir is affected by ATP-binding cassette (ABC) efflux
PMID 26169552

Determination of abacavir, tenofovir, darunavir, and raltegravir in human plasma and saliva using liquid chromatography coupled with tandem mass spectrometry.

Yamada E1, Takagi R1, Sudo K2, Kato S3.
Journal of pharmaceutical and biomedical analysis.J Pharm Biomed Anal.2015 Oct 10;114:390-7. doi: 10.1016/j.jpba.2015.06.005. Epub 2015 Jun 10.
A liquid chromatography-tandem mass spectrometry assay for the determination of abacavir (ABC), tenofovir (TFV), darunavir (DRV), and raltegravir (RAL) in human plasma and saliva was developed and validated to investigate the applicability of saliva as an appropriate specimen for therapeutic drug mo
PMID 26112927

Lamb G1, Choi KL1, Selwyn C1, Wheeler A1, Hammond L1, Morgan J1, Dunn PP1.
International journal of immunogenetics.Int J Immunogenet.2015 Oct;42(5):361-3. doi: 10.1111/iji.12221. Epub 2015 Jul 24.
Seven new HLA class I alleles have been identified in the New Zealand population in the process of routine HLA typing and they are described here. Unusual bead positivity in Luminex typing identified potential new alleles in a bone marrow registry donor (B*40:285) and two HIV patients prior to abaca
PMID 26212036