VCJD

同

variant Creutzfeldt-Jakob disease

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/09/12 01:03:02」(JST)

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Variant Creutzfeldt-Jakob disease (vCJD) or new variant Creutzfeldt-Jakob disease (nvCJD) is a transmissible spongiform encephalopathy which was identified in 1996 by the National CJD Surveillance Unit in Edinburgh. Over 170 cases of vCJD have been recorded in the United Kingdom, and around 30 cases in the rest of the world. The fact that the epidemiology of the disease coincided with an epidemic of Bovine spongiform encephalopathy led to the hypothesis that consumption of BSE-infected beef caused the disease.

Despite the consumption of contaminated beef in the UK being reckoned to be quite high, vCJD has infected a comparatively small cohort of people. One explanation for this can be found in the genetics of patients with the disease. All tested vCJD patients have been shown to have two copies of an altered version of the prion protein gene.

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• 1. 変異型クロイツフェルト・ヤコブ病 variant creutzfeldt jakob disease
• 2. クロイツフェルト・ヤコブ病 creutzfeldt jakob disease
• 3. 供血者スクリーニングに用いる手順：供血者および受血者の候補者保護 procedures used for blood donor screening protection of potential blood donors and recipients
• 4. プリオンによる中枢神経系疾患 diseases of the central nervous system caused by prions
• 5. 供血者の病歴 blood donor medical history

English Journal

• UK approach to assessing assays and filters designed to reduce the risk of transfusion-transmitted vCJD.

• Thomas S, Turner ML, Williamson LM.SourceNHS Blood and Transplant, Oak House, Reeds Crescent, Watford, WD24 4QN, England, United Kingdom. Electronic address: stephen.thomas@nhsbt.nhs.uk.
• Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine.Transfus Clin Biol.2013 Aug 5. pii: S1246-7820(13)00481-3. doi: 10.1016/j.tracli.2013.05.002. [Epub ahead of print]
• Three cases of vCJD transmission by blood transfusion have been reported in the UK, and a fourth case discovered at post-mortem. Modelling has been conducted to predict the number of cases that may occur in the future through transfusion, based on estimates of prevalence, infectivity and susceptibil
• PMID 23928183

• An overview of the diagnostic tools.

• Coste J.SourceLaboratoire R&D sécurité transfusionnelle et innovation diagnostique (TransDiag), établissement français du sang de Pyrénées-Méditerranée, 392, avenue du Professeur-Jean-Louis-Viala, 34184 Montpellier cedex 3, France. Electronic address: joliette.coste@efs.sante.fr.
• Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine.Transfus Clin Biol.2013 Aug 5. pii: S1246-7820(13)00479-5. doi: 10.1016/j.tracli.2013.04.110. [Epub ahead of print]
• Prions are unconventional infectious agents that cause fatal neurological illnesses such as Creutzfeldt-Jakob disease (CJD), bovine spongiform encephalopathy, and scrapie. Variant CJD can occur via blood transfusions. However, as no screening assay is available, uncertainties remain over the prevale
• PMID 23928182

• Assessment of prion reduction filters in decreasing infectivity of ultracentrifuged 263K scrapie-infected brain homogenates in "spiked" human blood and red blood cells.

• Cardone F, Sowemimo-Coker S, Abdel-Haq H, Sbriccoli M, Graziano S, Valanzano A, Berardi VA, Galeno R, Puopolo M, Pocchiari M.SourceDepartment of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Rome, Italy.
• Transfusion.Transfusion.2013 Aug 5. doi: 10.1111/trf.12369. [Epub ahead of print]
• BACKGROUND: The safety of red blood cells (RBCs) is of concern because of the occurrence of four transfusion-transmitted variant Creutzfeldt-Jakob disease (vCJD) cases in the United Kingdom. The absence of validated screening tests requires the use of procedures to remove prions from blood to minimi
• PMID 23915063

Japanese Journal

• 変異型Creutzfeldt-Jakob病 (認知症学(下)その解明と治療の最新知見) -- (臨床編)

• 八谷 如美,金子 清俊
• 日本臨床 69 (1012増刊10), 419-422, 2011-12
• NAID 40019128312

• The first Japanese patient with variant Creutzfeldt-Jakob disease (vCJD)

• SHINDE Akiyo,KUNIEDA Takenobu,KINOSHITA Yoshimi,WATE Reika,NAKANO Satoshi,ITO Hidefumi,YAMADA Masahito,KITAMOTO Tetsuyuki,NAKAMURA Yosikazu,MATSUMOTO Sadayuki,KUSAKA Hirofumi
• Neuropathology : official journal the Japanese Society of Neuropathology 29(6), 713-719, 2009-12-01
• NAID 10028192866

• Antibody-based immunotherapeutic attempts in experimental animal models of prion diseases.

• Sakaguchi Suehiro,Ishibashi Daisuke,Matsuda Haruo
• Expert opinion on therapeutic patents 19(7), 907-917, 2009-07
• … In contrast, the risk of human-to-human transmission of variant Creutzfeldt-Jakob disease (vCJD) via medical treatments became potentially high since 4 vCJD cases were reported to be possibly transmitted through blood transfusion in the UK. …
• NAID 120002272546

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異型クロイツフェルト・ヤコブ病

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