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1. 2本鎖（ds）DNA、Sm、およびU1 RNPに対する抗体 antibodies to double stranded ds dna sm and u1 rnp
2. 混合性結合組織病における抗U1-RNP抗体 anti u1 rnp antibodies in mixed connective tissue disease
3. 様々な抗核抗体 miscellaneous antinuclear antibodies
4. 混合性結合組織病の定義および診断 definition and diagnosis of mixed connective tissue disease
5. 混合性結合組織病の臨床症状 clinical manifestations of mixed connective tissue disease

Structure-function analysis of the 5' end of yeast U1 snRNA highlights genetic interactions with the Msl5*Mud2 branchpoint-binding complex and other spliceosome assembly factors.

Schwer B, Chang J, Shuman S.SourceMicrobiology and Immunology Department, Weill Cornell Medical College, New York, NY 10065, USA and Molecular Biology Program, Sloan-Kettering Institute, New York, NY 10065, USA.
Nucleic acids research.Nucleic Acids Res.2013 Aug 1;41(15):7485-500. doi: 10.1093/nar/gkt490. Epub 2013 Jun 10.
Yeast pre-mRNA splicing initiates via formation of a complex comprising U1 snRNP bound at the 5' splice site (5'SS) and the Msl5•Mud2 heterodimer engaged at the branchpoint (BP). Here, we present a mutational analysis of the U1 snRNA, which shows that although enlarging the 5' leader between the T
PMID 23754852

The role of the C-terminal helix of U1A protein in the interaction with U1hpII RNA.

Law MJ, Lee DS, Lee CS, Anglim PP, Haworth IS, Laird-Offringa IA.SourceDepartment of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA, Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA and Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA.
Nucleic acids research.Nucleic Acids Res.2013 Aug 1;41(14):7092-100. doi: 10.1093/nar/gkt326. Epub 2013 May 22.
Previous kinetic investigations of the N-terminal RNA Recognition Motif (RRM) domain of spliceosomal A protein of the U1 small nuclear ribonucleoprotein particle (U1A) interacting with its RNA target U1 hairpin II (U1hpII) provided experimental evidence for a 'lure and lock' model of binding. The fi
PMID 23703211

The nuclear cap-binding complex interacts with the U4/U6·U5 tri-snRNP and promotes spliceosome assembly in mammalian cells.

Pabis M, Neufeld N, Steiner MC, Bojic T, Shav-Tal Y, Neugebauer KM.SourceMax Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany.
RNA (New York, N.Y.).RNA.2013 Aug;19(8):1054-63. doi: 10.1261/rna.037069.112. Epub 2013 Jun 21.
The nuclear cap-binding complex (CBC) binds to the 7-methyl guanosine cap present on every RNA polymerase II transcript. CBC has been implicated in many aspects of RNA biogenesis; in addition to roles in miRNA biogenesis, nonsense-mediated decay, 3'-end formation, and snRNA export from the nucleus,
PMID 23793891

Reeves Westley H.,Han Shuhong,Weinstein Jason,Li Yi
日本臨床免疫学会会誌 35(4), 296-296, 2012
… Autoantibodies against the U1 snRNP (anti-Sm/RNP) are strongly associated with SLE. … Ectopic lymphoid tissue (ELT) from mice with pristane-lupus was transplanted to naïve mice to examine development of anti-U1A (RNP) B cells. … Plasma cells and/or plasmablasts (PC/PB) capable of transferring autoantibody production to the recipient mice were enriched in ELT whereas U1A-specific memory B cells were present in the spleen and bone marrow. …
NAID 130004875909

Multiple factors in the early splicing complex are involved in the nuclear retention of pre-mRNAs in mammalian cells.

Takemura Reiko,Takeiwa Toshihiko,Taniguchi Ichiro,McCloskey Asako,Ohno Mutsuhito
Genes to cells 16(10), 1035-1049, 2011-09-19
… Using a model reporter gene, we show here that U1 snRNP and U2AF but not U2 snRNP are essential for the nuclear retention of pre-mRNAs in mammalian cells, showing that E complex is the major entity responsible for the nuclear retention of pre-mRNAs in mammalian cells. …
NAID 120005593652