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spirochete that causes disease in humans (e.g. syphilis and yaws)

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/09/22 02:33:50」(JST)

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Treponema denticola is a gram-negative, obligate anaerobic, motile and highly proteolytic bacterium. The Gram-negative oral spirochete is associated with the incidence and severity of human periodontal disease. Treponema denticola levels in the mouth are elevated in patients with periodontal diseases and the species is considered one of the main etiological agents of periodontitis. ^[1]

T. denticola dwells in a complex and diverse microbial community in the oral cavity and is highly specialized to survive in this environment.

T. denticola is related to the syphilis-causing obligate human pathogen, Treponema pallidum subsp. pallidum.

Periodontal disease

Periodontal disease is an infection and inflammation of the gingiva resulting in destruction of the surrounding tissues and alveolar bone. It occurs in 15% of adults at some time in their lives and can lead to bleeding on brushing, halitosis, tooth mobility and loss. Severe forms include aggressive periodontitis and necrotizing periodontitis which can cause rapid bone resorption and tooth loss along with ulceration of the gingiva and considerable pain.

Treatment involves removal of plaque and calculus on the root surfaces by scaling and root planing using various periodontal currettes. If the periodontal disease does not resolve, given at least 8–12 weeks for healing, the area is retreated. Periodontal surgery to raise a flap and root plane the affected teeth may be undertaken along with antibiotic therapy (systemic or local).

References

^ Jobin M-C et al. (2008). "The Molecular Biology of the Survival and Virulence of Treponema denticola". Molecular Oral Microbiology. Caister Academic Press. ISBN 978-1-904455-24-0.

UpToDate Contents

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1. 歯性感染症の疫学、病因、および臨床症状 epidemiology pathogenesis and clinical manifestations of odontogenic infections
2. 小児および思春期における歯肉炎および歯周炎：概要 gingivitis and periodontitis in children and adolescents an overview
3. 早期分娩の危険因子 risk factors for preterm labor and delivery

English Journal

Detection of periodontal pathogens in newborns and children with mixed dentition.

Cortelli JR, Fernandes CB, Costa FO, Cortelli SC, Kajiya M, Howell SC, Kawai T.SourceDepartment of Periodontology and Preventive Dentistry, Dental Research Division, University of Taubate, 51 Visconde do Rio Branco, Taubaté, SP, 12020-040, Brazil, jrcortelli@uol.com.br.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology.Eur J Clin Microbiol Infect Dis.2012 Jun;31(6):1041-50. Epub 2011 Sep 18.
We report the age-related prevalence of red complex periodontal pathogens, Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia, along with four strains of orange complex pathogens. The bacteria present in samples isolated from tongue, cheek, and subgingival sulcus in edentulous n
PMID 21928086

The short-term treatment effects on the microbiota at the dorsum of the tongue in intra-oral halitosis patients-a randomized clinical trial.

Ademovski SE, Persson GR, Winkel E, Tangerman A, Lingström P, Renvert S.SourceDepartment of Oral Health Science, Section for Health and Society, Kristianstad University, Kristianstad, Sweden.
Clinical oral investigations.Clin Oral Investig.2012 May 10. [Epub ahead of print]
OBJECTIVES: This study aims to assess the effects of rinsing with zinc- and chlorhexidine-containing mouth rinse with or without adjunct tongue scraping on volatile sulfur compounds (VSCs) in breath air, and the microbiota at the dorsum of the tongue.MATERIAL AND METHODS: A randomized single-masked
PMID 22573244

Japanese Journal

歯周炎患者における抗菌ペプチドLL-37の臨床的意義

北川原聡
日本歯周病学会会誌 52(4), 401-408, 2010-12-28
… denticola, A. … denticolaやA. … denticolaの存在と唾液中のLL-37濃度との関連が示唆された。 …
NAID 10027692092

Virulence factors of Treponema denticola

Ishihara K
Periodontology 2000 54(1), 117-135, 2010-10
NAID 120002648149

「トレポネーマ属」

Treponema denticola
Scientific classification
Domain:	Bacteria
Phylum:	Spirochaetes
Order:	Spirochaetales
Family:	Spirochaetaceae
Genus:	Treponema
Species:	T. denticola