WordNet

small room in which a monk or nun lives (同)cubicle
a device that delivers an electric current as the result of a chemical reaction (同)electric cell
a room where a prisoner is kept (同)jail cell, prison cell
(biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
any small compartment; "the cells of a honeycomb"
a small unit serving as part of or as the nucleus of a larger political movement (同)cadre
an abnormal new mass of tissue that serves no purpose (同)tumour, neoplasm

PrepTutorEJDIC

(刑務所の)『独房』;(修道院の)小さい独居室 / (ミツバチの)みつ房,巣穴 / 小さい部屋 / 『細胞』 / 電池 / 花粉室 / (共産党などの)細胞

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/09/22 00:31:28」(JST)

wiki en

Sertoli–Leydig cell tumour is a group of tumours composed of variable proportions of Sertoli cells, Leydig cells, and in the case of intermediate and poorly differentiated neoplasms, primitive gonadal stroma and sometimes heterologous elements.^[1]

Sertoli–Leydig cell tumour is a member of the sex cord-stromal tumour group^[2] of ovarian and testicular cancers. The tumour is rare, comprising less than 1% of testicular tumours.^[1] While the tumour can occur at any age, it occurs most often in young adults. Recent studies have shown that many cases of Sertoli–Leydig cell tumor of the ovary are caused by germline mutations in the DICER1 gene.^[3]^[4] These hereditary cases tend to be younger, often have a multinodular thyroid goiter and there may be a personal or family history of other rare tumors such as pleuropulmonary blastoma, Wilms tumor and cervical rhabdomyosarcoma.

Closely related terms include arrhenoblastoma^[5] and androblastoma.^[6] Both terms are classified under Sertoli–Leydig cell tumour in MeSH.

Classification

The tumour is subdivided into many different subtypes. The most typical is composed of tubules lined by Sertoli cells and interstitial clusters of Leydig cells.

Presentation

Due to excess testosterone secreted by the tumour, one-third of female patients present with a recent history of progressive masculinization. Masculinization is preceded by anovulation, oligomenorrhoea, amenorrhoea and defeminization. Additional signs include acne and hirsutism, voice deepening, clitoromegaly, temporal hair recession, and an increase in musculature. Serum testosterone level is high.

Diagnosis

Presence of an ovarian tumour plus hormonal disturbances suggests a Sertoli–Leydig cell tumour. However, hormonal disturbance is present in only 2/3 of cases. A conclusive diagnosis is made via histology, as part of a pathology report made during or after surgery. See also Sex cord-stromal tumour.

Treatment

The usual treatment is surgery. The surgery usually is a fertility-sparing unilateral salpingo-oophorectomy. For malignant tumours, the surgery may be radical and usually is followed by adjuvant chemotherapy, sometimes by radiation therapy. In all cases, initial treatment is followed by surveillance. Because in many cases Sertoli–Leydig cell tumour does not produce elevated tumour markers,^[7] the focus of surveillance is on repeated physical examination and imaging. Given that many cases of Sertoli–Leydig cell tumor of the ovary are hereditary, referral to a clinical genetics service should be considered.

The prognosis is generally good as the tumour tends to grow slowly and usually is benign: 25% are malignant.^{[citation needed]} For malignant tumours with undifferentiated histology, prognosis is poor.^[7]

Additional images

High magnification micrograph of a Leydig cell tumour. H&E stain.
High magnification micrograph of a Sertoli cell tumour. H&E stain.

References

^ ^a ^b WHO, 2003^{[verification needed]}
^ Sachdeva, Poonam; Arora, Raksha; Dubey, Chandan; Sukhija, Astha; Daga, Mridula; Kumar Singh, Deepak (2008). "Sertoli–Leydig cell tumor: A rare ovarian neoplasm. Case report and review of literature". Gynecological Endocrinology 24 (4): 230–4. doi:10.1080/09513590801953465. PMID 18382911.
^ Frio, Thomas Rio; Bahubeshi, Amin; Kanellopoulou, Chryssa; Hamel, Nancy; Niedziela, Marek; Sabbaghian, Nelly; Pouchet, Carly; Gilbert, Lucy; O'Brien, Paul K. (2011). "DICER1 Mutations in Familial Multinodular Goiter With and Without Ovarian Sertoli-Leydig Cell Tumors". JAMA 305 (1): 68–77. doi:10.1001/jama.2010.1910. PMC 3406486. PMID 21205968.
^ Slade, Ingrid; Bacchelli, Chiara; Davies, Helen; Murray, Anne; Abbaszadeh, Fatemeh; Hanks, Sandra; Barfoot, Rita; Burke, Amos; Chisholm, Julia (2011). "DICER1 syndrome: clarifying the diagnosis, clinical features and management implications of a pleiotropic tumour predisposition syndrome". Journal of Medical Genetics 48 (4): 273–8. doi:10.1136/jmg.2010.083790. PMID 21266384.
^ "arrhenoblastoma" at Dorland's Medical Dictionary
^ "androblastoma" at Dorland's Medical Dictionary
^ ^a ^b Lenhard, Miriam; Kuemper, Caroline; Ditsch, Nina; Diebold, Joachim; Stieber, Petra; Friese, Klaus; Burges, Alexander (2007). "Use of novel serum markers in clinical follow-up of Sertoli–Leydig cell tumours". Clinical Chemistry and Laboratory Medicine 45 (5): 657–61. doi:10.1515/CCLM.2007.120. PMID 17484630.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 卵巣の性索間質腫瘍：セルトリ・間質細胞腫瘍 sex cord stromal tumors of the ovary sertoli stromal cell tumors
2. 卵巣の性索間質腫瘍の概要 overview of sex cord stromal tumors of the ovary
3. 卵巣の性索間質腫瘍：顆粒膜細胞腫瘍およびセルトリ・ライディック細胞腫 sex cord stromal tumors of the ovary tumors with granulosa and sertoli leydig elements
4. 男性型多毛症の病因と原因 pathogenesis and causes of hirsutism
5. 卵巣の性索間質腫瘍：顆粒膜-間質細胞腫瘍 sex cord stromal tumors of the ovary granulosa stromal cell tumors

English Journal

Gonadoblastoma and hepatoid and endometrioid-like yolk sac tumor: an update.

Ulbright TM.
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists.Int J Gynecol Pathol.2014 Jul;33(4):365-73. doi: 10.1097/PGP.0000000000000134.
Dr Robert E. Scully greatly advanced our understanding of germ cell neoplasia to the extent that it is difficult to narrow the discussion of his contributions to this topic so that it can be covered in a brief article. This article accordingly focuses on some of the recent developments concerning 2
PMID 24901396

Judicious DICER1 testing and surveillance imaging facilitates early diagnosis and cure of pleuropulmonary blastoma.

Schultz KA1, Harris A, Williams GM, Baldinger S, Doros L, Valusek P, Frazier AL, Dehner LP, Messinger Y, Hill DA.
Pediatric blood & cancer.Pediatr Blood Cancer.2014 May 13. doi: 10.1002/pbc.25092. [Epub ahead of print]
Pleuropulmonary blastoma (PPB) and Sertoli-Leydig cell tumor (SLCT) are both associated with germline mutations in DICER1. In this brief report, a maternal history of SLCT led to identification of a deleterious DICER1 mutation in the patient and her asymptomatic infant. Radiographic screening reveal
PMID 24821309

Starvation is more efficient than the washing technique for purification of rat Sertoli cells.

Ghasemzadeh-Hasankolaei M1, Eslaminejad MB, Sedighi-Gilani M, Mokarizadeh A.
In vitro cellular & developmental biology. Animal.In Vitro Cell Dev Biol Anim.2014 May 2. [Epub ahead of print]
Sertoli cells (SCs), one of the most important components of seminiferous tubules, are vital for normal spermatogenesis and male fertility. In recent years, numerous in vitro studies have shown the potential and actual activities of SCs. However, pure SCs are necessary for various in vitro studies.
PMID 24789729

Japanese Journal

B-6)横紋筋への分化を示すSertoli-Leydig cell tumorの1例(B 肺,肝,卵巣腫瘍,2010年度小児腫瘍症例検討会)

若松早穂,北條洋,阿部正文
小児がん : 小児悪性腫瘍研究会記録 48(1), 45, 2011-02-25
NAID 110008608593

P2-3-4 インスリン抵抗性改善薬pioglitazone投与とダイエットが奏効したSertoli-Leydig cell tumor摘出後の2次性PCOS症例からの新知見(Group75 生殖医学(症例)3,一般演題,第63回日本産科婦人科学会学術講演会)

清水亜由美,遠藤俊明,長澤邦彦,馬場剛,高田さくら,高橋円,石岡伸一,斎藤豪
日本産科婦人科學會雜誌 63(2), 715, 2011-02-01
NAID 110008509569

Ovarian Sertoli-Leydig Cell Tumor with a Component Which Differentiated into Hepatocytes and Produces High Serum Alpha-Fetoprotein

FUJIBAYASHI 　Mariko,AIBA 　Motohiko,IDE 　Sanae,NAGANO 　Hiroaki,TAKAGI 　Koichiro,藤林　真理子,相羽　元彦,井出　早苗,長野　浩明,高木　耕一郎
東京女子医科大学雑誌 80(1/2), 17-23, 2010-02-25
NAID 80020849232

Related Pictures

★リンクテーブル★

リンク元	「セルトリ・ライディッヒ細胞腫」「androblastoma」「Sertoli-Leydig細胞腫」「arrhenoblastoma」
拡張検索	「Sertoli-Leydig cell tumors」
関連記事	「tumor」「cell」

「セルトリ・ライディッヒ細胞腫」

Sertoli–Leydig cell tumour
	Classification and external resources
	Micrograph of a Sertoli–Leydig cell tumour. The Leydig cells have abundant eosinophilic or light pink cytoplasm. The Sertoli cells have a pale/clear cytoplasm. H&E stain.
ICD-9	183.0, 256.1
ICD-O:	8630-8631/0
MedlinePlus	001172
MeSH	D018310

　　[★]

英: Sertoli-Leydig cell tumor
同: Sertoli-Leydig細胞腫、男性化細胞腫 arrhenoblastoma
関: androblastoma、arrhenoblastoma

精巣特異的な細胞が認められる卵巣腫瘍

「androblastoma」

　　[★]

セルトリ間質細胞腫瘍、アンドロブラストーマ

関: arrhenoblastoma、Sertoli-Leydig cell tumor

「Sertoli-Leydig細胞腫」

　　[★]

英: Sertoli-Leydig cell tumor
関: セルトリ・ライディッヒ細胞腫

「arrhenoblastoma」

　　[★]

男化腫瘍

関: androblastoma、Sertoli-Leydig cell tumor

「Sertoli-Leydig cell tumors」

　　[★] セルトリ・ライディッヒ細胞腫

「tumor」

　　[★]

n.

腫瘍、腫瘤、腫脹

「cell」

　　[★] 細胞　　　　　　　

[WHO2003-1] WHO, 2003^{[verification needed]}

[pmid18382911-2] Sachdeva, Poonam; Arora, Raksha; Dubey, Chandan; Sukhija, Astha; Daga, Mridula; Kumar Singh, Deepak (2008). "Sertoli–Leydig cell tumor: A rare ovarian neoplasm. Case report and review of literature". Gynecological Endocrinology 24 (4): 230–4. doi:10.1080/09513590801953465. PMID 18382911.

[3] Frio, Thomas Rio; Bahubeshi, Amin; Kanellopoulou, Chryssa; Hamel, Nancy; Niedziela, Marek; Sabbaghian, Nelly; Pouchet, Carly; Gilbert, Lucy; O'Brien, Paul K. (2011). "DICER1 Mutations in Familial Multinodular Goiter With and Without Ovarian Sertoli-Leydig Cell Tumors". JAMA 305 (1): 68–77. doi:10.1001/jama.2010.1910. PMC 3406486. PMID 21205968.

[4] Slade, Ingrid; Bacchelli, Chiara; Davies, Helen; Murray, Anne; Abbaszadeh, Fatemeh; Hanks, Sandra; Barfoot, Rita; Burke, Amos; Chisholm, Julia (2011). "DICER1 syndrome: clarifying the diagnosis, clinical features and management implications of a pleiotropic tumour predisposition syndrome". Journal of Medical Genetics 48 (4): 273–8. doi:10.1136/jmg.2010.083790. PMID 21266384.

[5] "arrhenoblastoma" at Dorland's Medical Dictionary

[6] "androblastoma" at Dorland's Medical Dictionary

[pmid17484630-7] Lenhard, Miriam; Kuemper, Caroline; Ditsch, Nina; Diebold, Joachim; Stieber, Petra; Friese, Klaus; Burges, Alexander (2007). "Use of novel serum markers in clinical follow-up of Sertoli–Leydig cell tumours". Clinical Chemistry and Laboratory Medicine 45 (5): 657–61. doi:10.1515/CCLM.2007.120. PMID 17484630.

匿名

検索

案内

案内

Sertoli-Leydig cell tumor