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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/02/18 09:26:35」(JST)

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Auranofin is a gold complex classified by the World Health Organization as an antirheumatic agent. It has the brand name Ridaura.

Use[edit]

Auranofin is used to treat rheumatoid arthritis. It improves arthritis symptoms including painful or tender and swollen joints and morning stiffness.^[1]

Research[edit]

HIV infection[edit]

Auranofin is under investigation as means of reducing the viral reservoir of HIV that lies latent in the body's T-cells despite treatment with antiretroviral therapy. ^[2]

Amebiasis[edit]

Auranofin has been identified in a high-throughput drug screen as 10 times more potent than metronidazole on Entamoeba histolytica, the protozoan agent of human amebiasis. Assays of thioredoxin reductase and transcriptional profiling suggest that the effect of auranofin on the enzyme enhances the sensitivity of the trophozoites to reactive oxygen-mediated killing in mouse and hamster models; the results are markedly reductions of the number of parasites, the inflammatory reaction to the infestation and the damage to the liver.^[3]^[4]^[5]

References[edit]

^ MedlinePlus DrugInfo medmaster-a685038
^ Gold-based drug shows promise in clearing HIV reservoir in monkey study. Keith Alcorn. AIDSmaps.com. Accessed 23 April 2011.
^ Debnath, Anjan; Parsonage, Derek; Andrade, Rosa M; He, Chen; Cobo, Eduardo R; Hirata, Ken; Chen, Steven; García-Rivera, Guillermina et al. (2012). "A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target". Nature Medicine. doi:10.1038/nm.2758. |displayauthors= suggested (help)
^ Drug Found for Parasite That Is Major Cause of Death Worldwide
^ Arthritis Drug Effective Against Global Parasite, Study Suggests

External links[edit]

MedlinePlus DrugInfo medmaster-a685038

UpToDate Contents

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1. 金の主な副作用 major side effects of gold
2. 関節リウマチにおける薬剤誘発性肺疾患 drug induced lung disease in rheumatoid arthritis
3. 金誘発性肺疾患 gold induced pulmonary disease
4. 成人における関節リウマチのマネージメントの一般的原則 general principles of management of rheumatoid arthritis in adults
5. リウマチ性疾患への金化合物の使用 use of gold compounds in rheumatic diseases

English Journal

Fourier Transform Infrared spectroscopy discloses different types of cell death in flow cytometrically sorted cells.

Le Roux K1, Prinsloo LC2, Meyer D3.
Toxicology in vitro : an international journal published in association with BIBRA.Toxicol In Vitro.2015 Aug 4. pii: S0887-2333(15)00187-3. doi: 10.1016/j.tiv.2015.08.002. [Epub ahead of print]
Fourier Transform Infrared (FTIR) spectroscopy is a label free methodology showing promise in characterizing different types of cell death. Cervical adenocarcinoma (HeLa) and African monkey kidney (Vero) cells were treated with a necrosis inducer (methanol), novel apoptotic inducers (diphenylphosphi
PMID 26254093

The effect of 1:2 Ag(I) thiocyanate complexes in MCF-7 breast cancer cells.

Ferreira E1, Munyaneza A, Omondi B, Meijboom R, Cronjé MJ.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine.Biometals.2015 Aug;28(4):765-81. doi: 10.1007/s10534-015-9865-5. Epub 2015 Jun 7.
There is much interest currently in the design of metal compounds as drugs and various metal compounds are already in clinical use. These include gold(I) compounds such as auranofin and the anti-cancer platinum(II) complex, cisplatin. Bis-chelated gold(I) phosphine complexes have also shown great po
PMID 26049979

Evidence that the antiproliferative effects of auranofin in Saccharomyces cerevisiae arise from inhibition of mitochondrial respiration.

Gamberi T1, Fiaschi T1, Modesti A1, Massai L2, Messori L2, Balzi M1, Magherini F3.
The international journal of biochemistry & cell biology.Int J Biochem Cell Biol.2015 Aug;65:61-71. doi: 10.1016/j.biocel.2015.05.016. Epub 2015 May 27.
Auranofin is a gold based drug in clinical use since 1985 for the treatment of rheumatoid arthritis. Beyond its antinflammatory properties, auranofin exhibits other attractive biological and pharmacological actions such as a potent in vitro cytotoxicity and relevant antimicrobial and antiparasitic e
PMID 26024642

Japanese Journal

Experimental induction of heterotopic bone in abdominal implants

ASCENCIO DANIEL,HERNANDEZ-PANDO ROGELIO,BARRIOS JORGE,SORIANO ROSA EUGENIA,PEREZ-GUILLE BEATRIZ,VILLEGAS FERNANDO,RIDAURA SANZ CECILIA,LOPEZ-CORELLA EDUARDO,CARRASCO DANIEL,FRENK F. SILVESTRE
Wound repair and regeneration 12(6), 643-649, 2004-11-01
NAID 10020396553

Progressive paralysis associated with diffuse astrocyte anaplasia in Δ202 mice homozygous for a transgene encoding the SV40 T antigen

LOPEZ-REVILLA Ruben,SOTO-ZARATE Carlos,RIDAURA Cecilia,CHAVEZ-DUENAS Lucia,PAUL Dieter
Neuropathology : official journal the Japanese Society of Neuropathology 24(1), 30-37, 2004-03-01
NAID 10014201041

<no title>

LOPEZ-RIDAURA R.
Diabetes Care 27, 134, 2004
NAID 30026279916

Related Pictures

诺芬胶囊）Ridaura(auranofin capsules Camping Ridaura - Girona Evaluaciones Camping Ridaura Description Riu Ridaura.jpg Faces of people named Ridaura Ridaura (Auranofin) - 3mg (60 Tablets) camping ridaura foto 1 camping ridaura Ridaura

★リンクテーブル★

リンク元

「オーラノフィン」

Auranofin
Systematic (IUPAC) name
	gold(+1) cation; 3,4,5-triacetyloxy-6- (acetyloxymethyl) oxane-2-thiolate; triethylphosphanium
Clinical data
Trade names	Ridaura
AHFS/Drugs.com	Consumer Drug Information
MedlinePlus	a685038
Pregnancy cat.	C (US)
Legal status	℞-only (US)
Routes	Oral
Identifiers
CAS number	34031-32-8
ATC code	M01CB03
PubChem	CID 6333901
DrugBank	DB00995
ChemSpider	21229878
UNII	3H04W2810V
KEGG	D00237
ChEBI	CHEBI:2922
ChEMBL	CHEMBL1366
Chemical data
Formula	C20H35AuO9PS+
Mol. mass	679.493 g/mol
	SMILES CC(=O)O[C@H]1O[C@@H](S[Au]P(CC)(CC)CC)[C@H](OC(C)=O)[C@@H](OC(C)=O)C1OC(C)=O;
	InChI InChI=1S/C13H18O9S.C6H15P.Au/c1-5(14)18-9-10(19-6(2)15)12(21-8(4)17)22-13(23)11(9)20-7(3)16;1-4-7(5-2)6-3;/h9-13,23H,1-4H3;4-6H2,1-3H3;/t9-,10?,11+,12-,13-;;/m0../s1 ; Key:JCUNAWURTWIACY-YHEXQHTOSA-N ;
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　　[★]

英: auranofin
商: リドーラ Ridaura、グレリース)、リザスト
関: 抗リウマチ薬

[1] MedlinePlus DrugInfo medmaster-a685038

[2] Gold-based drug shows promise in clearing HIV reservoir in monkey study. Keith Alcorn. AIDSmaps.com. Accessed 23 April 2011.

[3] Debnath, Anjan; Parsonage, Derek; Andrade, Rosa M; He, Chen; Cobo, Eduardo R; Hirata, Ken; Chen, Steven; García-Rivera, Guillermina et al. (2012). "A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target". Nature Medicine. doi:10.1038/nm.2758. |displayauthors= suggested (help)

[4] Drug Found for Parasite That Is Major Cause of Death Worldwide

[5] Arthritis Drug Effective Against Global Parasite, Study Suggests

匿名

検索

案内

案内

Ridaura