関: See Ryanodine receptor

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the 18th letter of the Roman alphabet (同)r

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resistance / 17歳以下父兄同伴映画の表示 / rook

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/01/16 10:33:01」(JST)

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1. 溺死（水没事故） drowning submersion injuries

English Journal

Ion channels of the nuclear membrane of hippocampal neurons.

Fedorenko OA1, Marchenko SM.Author information 1Bogomoletz Institute of Physiology, Department of Brain Physiology, 4 Bogomoletz Street, Kiev, 01024, Ukraine; State Key Laboratory of Molecular and Cellular Biology, 4 Bogomoletz Street, Kiev, 01024, Ukraine.AbstractRise in Ca2+ concentration in the nucleus affects gene transcription and has been implicated in neuroprotection, transcription-dependent neuronal plasticity and pain modulation, but the mechanism of regulation of nuclear Ca2+ remains poorly understood. The nuclear envelope is a part of the endoplasmic reticulum and may be one of the sources of nuclear Ca2+ . Here we studied ion channels in the nuclear membrane of hippocampal neurons using the patch-clamp technique. We have found that the nuclear membrane of CA1 pyramidal and dentate gyrus granule (DG), but not CA3 pyramidal neurons, was enriched in functional inositol 1,4,5-trisphosphate receptors/Ca2+ -release channels (IP3 Rs) localized mainly in the inner nuclear membrane. A single nuclear ryanodine receptor (RyR) has been detected only in DG granule neurons. Nuclei of the hippocampal neurons also expressed a variety of spontaneously active cation and anion channels specific for each type of neuron. In particular, large-conductance ion channels selective for monovalent cations (LCC) were coexpressed with IP3 Rs. These data suggest that: (1) the nuclear membranes of hippocampal neurons contain distinct sets of ion channels, which are specific for each type of neuron; (2) IP3 Rs, but not RyRs are targeted to the inner nuclear membrane of CA1 pyramidal and DG granule, but they were not found in the nuclear membranes of CA3 pyramidal neurons; (3) the nuclear envelope of these neurons is specialized to release Ca2+ into the nucleoplasm which may amplify Ca2+ signals entering the nucleus from the cytoplasm or generate Ca2+ transients on its own; (4) LCC channels are an integral part the of Ca2+ -releasing machinery providing a route for counterflow of К+ and thereby facilitating Ca2+ movement in and out of the Ca2+ store. © 2014 Wiley Periodicals, Inc.
Hippocampus.Hippocampus.2014 Apr 8. doi: 10.1002/hipo.22276. [Epub ahead of print]
Rise in Ca2+ concentration in the nucleus affects gene transcription and has been implicated in neuroprotection, transcription-dependent neuronal plasticity and pain modulation, but the mechanism of regulation of nuclear Ca2+ remains poorly understood. The nuclear envelope is a part of the endoplasm
PMID 24710998

RyR channel-mediated increase of cytosolic free calcium level signals cyclin B1 degradation during abortive spontaneous egg activation in rat.

Premkumar KV1, Chaube SK.Author information 1Cell Physiology Laboratory, Department of Zoology, Banaras Hindu University, Varanasi, 221005, India.AbstractIn few mammalian species including rat, post-ovulatory aging induces abortive spontaneous egg activation (SEA), which is morphologically characterized by exit from metaphase-II (M-II) arrest. A possibility exists that the RyR channel-mediated insufficient increase of cytosolic free Ca2+ level could be one of the causes for post-ovulatory aging-induced abortive SEA. To test this possibility, eggs collected after 17 h post-hCG surge were cultured with or without various concentrations of nifedipine (NF), ruthenium red (RR), and KN-93 for 3 h in vitro. Morphological changes characteristic of abortive SEA, cytosolic free Ca2+ level, cyclin B1 level, and meiotic status were analyzed. Data of the present study indicate that NF and RR inhibited post-ovulatory aging-induced abortive SEA in a concentration-dependent manner. Further, RR protected against RyR channel as well as caffeine-mediated increase of cytosolic free Ca2+ level. In addition, KN-93 inhibited post-ovulatory aging-induced abortive SEA in a concentration-dependent manner. An increase of cytosolic free Ca2+ level was associated with a reduction of cyclin B1 level during post-ovulatory aging-induced abortive SEA. These data indirectly suggest the involvement of RyR channels in the increase of cytosolic free Ca2+ level. The increased cytosolic free Ca2+ level triggers cyclin B1 degradation possibly through CaMK-II activity during post-ovulatory aging-induced abortive SEA in rat eggs cultured in vitro.
In vitro cellular & developmental biology. Animal.In Vitro Cell Dev Biol Anim.2014 Apr 3. [Epub ahead of print]
In few mammalian species including rat, post-ovulatory aging induces abortive spontaneous egg activation (SEA), which is morphologically characterized by exit from metaphase-II (M-II) arrest. A possibility exists that the RyR channel-mediated insufficient increase of cytosolic free Ca2+ level could
PMID 24696373

Fluorescent probes for insect ryanodine receptors: candidate anthranilic diamides.

Wang Y1, Guo L2, Qi S3, Zhang H4, Liu K5, Liu R6, Liang P7, Casida JE8, Liu S9.Author information 1Department of Applied Chemistry, College of Science, China Agricultural University, No. 2 Yuanmingyuan West Road, Beijing 100193, China. royalwy@gmail.com.2College of Agriculture and Biotechnology, China Agricultural University, No. 2 Yuanmingyuan West Road, Beijing 100193, China. guoleicau@hotmail.com.3Department of Applied Chemistry, College of Science, China Agricultural University, No. 2 Yuanmingyuan West Road, Beijing 100193, China. ectl@berkeley.edu.4Department of Applied Chemistry, College of Science, China Agricultural University, No. 2 Yuanmingyuan West Road, Beijing 100193, China. cauzhanghao@gmail.com.5Department of Applied Chemistry, College of Science, China Agricultural University, No. 2 Yuanmingyuan West Road, Beijing 100193, China. lucklkc@163.com.6Department of Applied Chemistry, College of Science, China Agricultural University, No. 2 Yuanmingyuan West Road, Beijing 100193, China. fengzilrq@163.com.7College of Agriculture and Biotechnology, China Agricultural University, No. 2 Yuanmingyuan West Road, Beijing 100193, China. liangcau@cau.edu.cn.8Department of Environmental Science, Policy, and Management, University of California, Berkeley, CA 94720-3112, USA. ectl@berkeley.edu.9Department of Applied Chemistry, College of Science, China Agricultural University, No. 2 Yuanmingyuan West Road, Beijing 100193, China. shangzho@cau.edu.cn.AbstractDiamide insecticides with high efficacy against pests and good environmental safety are broadly applied in crop protection. They act at a poorly-defined site in the very complex ryanodine (Ry) receptor (RyR) potentially accessible to a fluorescent probe. Two N-propynyl analogs of the major anthranilic diamide insecticides chlorantraniliprole (Chlo) and cyantraniliprole (Cyan) were accordingly synthesized and converted into two fluorescent ligands by click reaction coupling with 3-azido-7-hydroxy-2H-chromen-2-one. The new diamide analogs and fluorescent ligands were shown to be nearly as potent as Chlo and Cyan in inhibition of [3H]Chlo binding and stimulation of [3H]Ry binding in house fly thoracic muscle RyR. Although the newly synthesized compounds had only moderate activity in insect larvicidal activity assays, their high in vitro potency in a validated insect RyR binding assay encourages further development of fluorescent probes for insect RyRs.
Molecules (Basel, Switzerland).Molecules.2014 Apr 2;19(4):4105-14. doi: 10.3390/molecules19044105.
Diamide insecticides with high efficacy against pests and good environmental safety are broadly applied in crop protection. They act at a poorly-defined site in the very complex ryanodine (Ry) receptor (RyR) potentially accessible to a fluorescent probe. Two N-propynyl analogs of the major anthranil
PMID 24699151

Japanese Journal

小西賞受賞者ダントロレンによるリアノジン受容体を分子標的とした新しい心不全・不整脈治療

桝田佳寛
山口医学 = Yamaguchi medical journal 62(1), 15-19, 2013-02
… 格筋型:RyR1心筋型:RyR2)内のドメイン連関障害が,リアノジン受容体からのCa^2+漏出の原因と考えられている.悪性高熱症の治療薬であるダントロレンは,RyR1に結合し,RyR1内のドメイン連関障害を是正することによってRyR1からのCa^{2+}漏出を抑制する.同様に,イヌ心不全モデルやCPVT型knock-inマウスにおいてもダントンは,RyR2に結 …
NAID 120005246291

Nitric oxide-induced calcium release: activation of type 1 ryanodine receptor by endogenous nitric oxide.

Kakizawa Sho,Yamazawa Toshiko,Iino Masamitsu
Channels 7(1), 1-5, 2013-01-01
… In addition to Ca2+-induced Ca2+ release in cardiac cells and voltage-induced Ca2+ release in skeletal muscle cells, we recently identified another mode of intracellular Ca2+ mobilization mediated by RyR, i.e., nitric oxide-induced Ca2+ release (NICR), in cerebellar Purkinje cells. … NICR is evoked by neuronal activity, is dependent on S-nitrosylation of type 1 RyR (RyR1) and is involved in the induction of long-term potentiation (LTP) of cerebellar synapses. …
NAID 120005333788

Regulatory Mechanisms and Pathophysiological Significance of IP3 Receptors and Ryanodine Receptors in Drug Dependence

Mizuno Koji,Kurokawa Kazuhiro,Ohkuma Seitaro
Journal of Pharmacological Sciences, 2013
… Although previous reports showed that the most important regulators of both RyR and IP3R channel functions are changes in the intracellular Ca2+ concentration and in phosphorylation of these channels by numerous kinases and calcium modulators, little information is available to clarify how the expression of intracellular calcium channels is regulated. …
NAID 130003382620

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